This Is MS Multiple Sclerosis Knowledge & Support Community

Selective Estrogen Receptor Modulator Enhances CNS Remyelination Independent of Estrogen Receptors (in vivo)

Free full text.

https://www.researchgate.net/publicatio ... _Receptors

NHE wrote: ↑Mon May 20, 2024 6:18 am Here's a study I posted a while back. It found increased Cmax and AUC for Na-R-Lipoate vs. R-Lopic Acid.

viewtopic.php?t=31875

More or less half quantity of Na-R-ALA is needed compared to R-ALA or R/S-ALA, perfect!

20 mg/kg/d is too much ALA and costs a lot. They don't mention what type of ALA they use. Unless a paper specifies R-Lipoic Acid or Na-R-Lipoate, I think it's safe to assume that Alpha Lipoic Acid refers to racemic R/S-Lipoic Acid. I assume with less quantity of Na-R-Lipoate we have the same result...

20 mg/kg/d is too much ALA and costs a lot.
They don't mention what type of ALA they use.
We all know that sodium salt of ALA especially in caps form is more stable, less sensitive to heat and light and has increased bioavailability, I don't know by how much though!

By searching the Cnicin (from Blessed Thistle) I found that Parthenolide (from Feverfew) promotes also nerve regeneration:
https://scholar.google.gr/scholar?q=par ... i=scholart

Wife takes daily among other supplements, 1 lozenge coenzymated B complex by Source Naturals (contains 25mg Calcium-D-Pantothenate), and 4 lozenges coenzymated B1 (25mg cocarboxylase each).
25mg coenzymated is equivalent to ~500mg of vitamin

Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found that oligodendrocytes in the lesions are epigenetically silenced. Develo...

The National Multiple Sclerosis Society has awarded Inflectis BioScience a grant valued at $649,601 to advance the preclinical development of IFB-048, the company’s experimental treatment to promote myelin repair in multiple sclerosis (MS). “This grant along with the support from the Society are a t...

A component in blessed thistle may have the potential to repair damaged nerves, investigators have found. Cnicin promotes functional nerve regeneration Phytomedicine. 2024 Apr 14:129:155641. https://www.sciencedirect.com/science/article/pii/S0944711324003003 Background : The limited regenerative cap...

The U.S. Food and Drug Administration has designated SetPoint Medical’s neurostimulator a breakthrough device for the treatment of relapsing-remitting multiple sclerosis (RRMS). This designation is intended to accelerate the development of devices intending to more effectively treat or diagnose life...

Curcumin Formulations for Better Bioavailability: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/ Thanks for the link to the paper. I hadn't seen that one. I take Longvida Curcumin . I was giving it to my wife until last year that I found CurQfen is more bioavailable, while Optima C-PC (Long...

Curcumin Formulations for Better Bioavailability:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061533/