Search found 1639 matches

by frodo
Wed Jun 15, 2022 12:31 am
Forum: MS Etiology and Pathogenesis
Topic: Simvastatin in phase III
Replies: 0
Views: 49

Simvastatin in phase III

Simvastatin starting a phase III trial. This is important because it is not an immune modulator. It is a cholesterol lowering drug and if it works, it will open new research paths about MS pathogenesis. https://www.mssociety.org.uk/research/latest-research/latest-research-news-and-blogs/we-have-wond...
by frodo
Mon Jun 06, 2022 11:42 am
Forum: MS Etiology and Pathogenesis
Topic: targeting astrocytes to prevent neurodegeneration
Replies: 0
Views: 40

targeting astrocytes to prevent neurodegeneration

Targeting astrocytes to prevent neurodegeneration in patients with multiple sclerosis https://www.tdx.cat/handle/10803/674407 Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS). Most MS patients initially have an inflammatory phase characterized by per...
by frodo
Fri Jun 03, 2022 3:35 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarker panel increases accuracy for identification of an MS relapse
Replies: 1
Views: 34

Biomarker panel increases accuracy for identification of an MS relapse

Biomarker panel increases accuracy for identification of an MS relapse beyond sNfL https://www.sciencedirect.com/science/article/pii/S2211034822004333 Highlights • Large-scale proteomics reveal serum markers associated with ongoing relapse in MS. • Steroids alter serum proteins and must be consider...
by frodo
Sun May 15, 2022 7:12 am
Forum: MS Etiology and Pathogenesis
Topic: New from lassman
Replies: 0
Views: 73

New from lassman

http://m.perspectivesinmedicine.cshlp.org/content/8/3/a028936.short Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to diffuse neurodegeneration in the entire brai...
by frodo
Tue May 10, 2022 8:32 am
Forum: MS Etiology and Pathogenesis
Topic: Early biomarkers
Replies: 0
Views: 78

Early biomarkers

Serum-Based Biomarkers in Neurodegeneration and Multiple Sclerosis https://www.mdpi.com/2227-9059/10/5/1077/htm Abstract Multiple Sclerosis (MS) is a debilitating disease with typical onset between 20 and 40 years of age, so the disability associated with this disease, unfortunately, occurs in the ...
by frodo
Tue May 10, 2022 1:55 am
Forum: MS Etiology and Pathogenesis
Topic: Microglia activation drives structural changes
Replies: 0
Views: 87

Microglia activation drives structural changes

Microglia activation in multiple sclerosis lesions drives structural changes over time and correlates with clinical progression https://cds.ismrm.org/protected/18MProceedings/PDFfiles/1973.html Synopsis In this study we develop a new method to generate individual maps of activated microglia from 18...
by frodo
Mon Apr 25, 2022 12:08 am
Forum: MS Etiology and Pathogenesis
Topic: Possibility of strengthening the BBB (poster)
Replies: 0
Views: 118

Possibility of strengthening the BBB (poster)

New treatment for multiple sclerosis could halt disease progression without weakening immune system https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=1055&context=library_studentposters_2022 Additional Information Dual Chimera claudin proteins have been shown to increase tight junctio...
by frodo
Mon Apr 25, 2022 12:00 am
Forum: MS Etiology and Pathogenesis
Topic: The MS prodrome could be around 6 years
Replies: 0
Views: 106

The MS prodrome could be around 6 years

The MS prodrome (since the beginning of the underlying disease to the RIS) could be around 6 years. Preventing disease progression in multiple sclerosis https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01044-8 Excerpt Insights gained from large international real-world cohorts de...
by frodo
Tue Apr 19, 2022 1:59 am
Forum: MS Etiology and Pathogenesis
Topic: Retrospective review of neuropathological studies
Replies: 0
Views: 187

Retrospective review of neuropathological studies

The Contribution of Neuropathology to Multiple Sclerosis Research https://pubmed.ncbi.nlm.nih.gov/35427431/ Abstract Background : Neuropathology played a major role in deciphering disease mechanisms in multiple sclerosis. Methods : Retrospective review of neuropathological studies, published during...
by frodo
Fri Apr 08, 2022 4:01 am
Forum: MS Etiology and Pathogenesis
Topic: Molecular Biomarkers to Monitor Treatment Effects
Replies: 0
Views: 265

Molecular Biomarkers to Monitor Treatment Effects

Update on Multiple Sclerosis Molecular Biomarkers to Monitor Treatment Effects https://www.mdpi.com/2075-4426/12/4/549/htm Abstract Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system characterized by broad inter- and intraindividual heterogeneity....
by frodo
Fri Apr 08, 2022 3:59 am
Forum: MS Etiology and Pathogenesis
Topic: Ms artificially induced in humans by mistake
Replies: 2
Views: 916

New case

New Developing Multiple Sclerosis in A Patient Using Tofacitinib Due To Alopesia Areata

https://onlinelibrary.wiley.com/doi/abs ... /dth.15477
by frodo
Fri Apr 08, 2022 3:58 am
Forum: MS Etiology and Pathogenesis
Topic: Slowly expanding lesions linked to progression
Replies: 0
Views: 181

Slowly expanding lesions linked to progression

Slowly expanding lesions are linked to multiple sclerosis progression

https://www.nature.com/articles/s41582-022-00654-5

Slowly expanding lesions (SELs) account for a substantial proportion of the brain lesions observed in individuals with SPMS ...
by frodo
Fri Apr 08, 2022 3:53 am
Forum: MS Etiology and Pathogenesis
Topic: Antibodies to blood coagulation in MS
Replies: 0
Views: 257

Antibodies to blood coagulation in MS

Antibodies to blood coagulation components are implicated in patients with multiple sclerosis https://www.sciencedirect.com/science/article/pii/S2211034822002905 Highlights • Antibodies to coagulant factors are involved to venous thromboembolism development. • They can trigger signaling inflammator...
by frodo
Thu Mar 17, 2022 3:18 pm
Forum: MS Etiology and Pathogenesis
Topic: CSF impairs remyelination
Replies: 0
Views: 224

CSF impairs remyelination

Cerebrospinal fluid of progressive multiple sclerosis patients reduces differentiation and immune functions of oligodendrocyte progenitor cells https://onlinelibrary.wiley.com/doi/full/10.1002/glia.24165 Abstract Oligodendrocyte progenitor cells (OPCs) are responsible for remyelination in the centr...
by frodo
Fri Mar 04, 2022 2:12 am
Forum: MS Etiology and Pathogenesis
Topic: Remyelination stops degeneration in MS
Replies: 0
Views: 253

Remyelination stops degeneration in MS

Probably this also means that degeneration is a direct consecuence of demyelination. This was not clear before this report. Remyelination stops degeneration in MS https://www.nature.com/articles/s41582-022-00638-5 Findings that remyelination protects axons from degeneration in animal models of multi...

Go to advanced search