Search found 1559 matches

by frodo
Mon May 03, 2021 2:23 am
Forum: MS Etiology and Pathogenesis
Topic: MS as a metabolic disease
Replies: 0
Views: 87

MS as a metabolic disease

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than autoimmunity https://link.springer.com/article/10.1007/s11011-021-00711-w Abstract In this Review (Part I), we investigate the scientific evidence th...
by frodo
Wed Apr 28, 2021 2:08 am
Forum: MS Etiology and Pathogenesis
Topic: automatic diagnosis of CNS diseases
Replies: 0
Views: 97

automatic diagnosis of CNS diseases

CSF biomarkers, processed by an algorithm, can help establishing an automatic diagnosis of CNS diseases.

https://academic.oup.com/brain/advance- ... login=true
by frodo
Tue Mar 16, 2021 10:55 am
Forum: MS Etiology and Pathogenesis
Topic: QSM-MRI can show brain inflammation.
Replies: 0
Views: 164

QSM-MRI can show brain inflammation.

QSM-MRI can show brain inflammation. Currently there is none. QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51338 Abstract Background: Inflammation in chronic active lesions occurs behind a closed bloo...
by frodo
Tue Mar 16, 2021 10:47 am
Forum: MS Etiology and Pathogenesis
Topic: MS transcriptome analysis
Replies: 1
Views: 186

Re: MS transcriptome analysis

looks like they are trying to separate RRMS from SPMS
by frodo
Mon Mar 08, 2021 8:32 pm
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers. Extensive review as of 2021
Replies: 0
Views: 184

Biomarkers. Extensive review as of 2021

https://www.sciencedirect.com/science/article/pii/S0960076021000637?casa_token=a5fL5oQjLCIAAAAA:j30jJv6tFVBDIzHlUixUFRnjwgaH8QwB6arVtvYOzPn3ZCapL5BaWI22-zaSxzW3njO6uiJwrw Biomarkers in Multiple sclerosis: what place for oxysterols? The main markers of multiple sclerosis that have been identified are...
by frodo
Mon Mar 08, 2021 8:17 pm
Forum: MS Etiology and Pathogenesis
Topic: MicroRNA in MS and other diseases
Replies: 0
Views: 181

MicroRNA in MS and other diseases

https://link.springer.com/article/10.1186/s41983-021-00289-1 MiRNA dysregulation multiple sclerosis MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to be consistently upregulated in MS patients including miR-142-3p, miR-145, miR-146a/b, miR-...
by frodo
Mon Mar 08, 2021 8:02 pm
Forum: MS Etiology and Pathogenesis
Topic: Teri helps recovering optic nerve
Replies: 0
Views: 168

Teri helps recovering optic nerve

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/1756286421997372 [...] Beneficial properties of TRF beyond pure peripheral immunomodulation have been hypothesized before. Preclinical data already indicated ben...
by frodo
Wed Feb 24, 2021 2:05 am
Forum: MS Etiology and Pathogenesis
Topic: TNF demyelination considered as MS
Replies: 0
Views: 228

TNF demyelination considered as MS

TNF-α blockers-associated multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0165572821000527?casa_token=9YIL51DL-zUAAAAA:xr58vN7m305DukZ3s2nwNgTkMSeF4AzF9SPqh8QkIdK4VJEF1ofpsRA7TIYHlJCKzPB3em-Fdg Conclusion Our study confirmed that the exposure to TNFα blockers can be associated...
by frodo
Sat Feb 20, 2021 3:39 am
Forum: MS Etiology and Pathogenesis
Topic: EBV theory of MS. Some diagrams.
Replies: 1
Views: 236

EBV theory of MS. Some diagrams.

A new paper about how EBV could lead to MS. I link the main diagram here below. Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00035-6 https://marlin-prod.literatumonline.com/cms/attachment/2e9709c7-...
by frodo
Mon Feb 08, 2021 11:02 am
Forum: MS Etiology and Pathogenesis
Topic: The lancet: More about the previous two epitopes
Replies: 0
Views: 204

The lancet: More about the previous two epitopes

Serum markers of multiple sclerosis - a new approach https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00022-0/fulltext Optic neuritis (ON) typically manifests with the classical triad of subacute unilateral vision loss, periocular pain and impaired colour vision. It is the first sy...
by frodo
Mon Feb 08, 2021 10:55 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: Two epitopes predict ON evolution to MS
Replies: 0
Views: 213

Biomarkers: Two epitopes predict ON evolution to MS

You can see what a "epitope" is at wikipedia: https://en.wikipedia.org/wiki/Epitope Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients https://www.sciencedirect.com/science/article/pii/S2352396421000049 Background Optic neuritis (ON) can o...
by frodo
Mon Feb 08, 2021 10:51 am
Forum: MS Etiology and Pathogenesis
Topic: plasmablast: 100% specificity
Replies: 0
Views: 169

plasmablast: 100% specificity

Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases. https://www.sciencedirect.com/science/article/pii/S2211034820307938?casa_token=9UQB0NGWXccAAAAA:E3kzPWSfqYQuls1HU7l2L7lWjR32NlEuQEzkHxe_McrlhwkWaUY_4CGfF6t1x2zursWb5UjNzQ...
by frodo
Sat Jan 30, 2021 3:48 am
Forum: MS Etiology and Pathogenesis
Topic: A unified view of multiple sclerosis
Replies: 0
Views: 657

A unified view of multiple sclerosis

A unified view of multiple sclerosis https://www.researchgate.net/profile/David_Pitt7/publication/348734921_A_unified_view_of_multiple_sclerosis/links/600dbe8b92851c13fe355c81/A-unified-view-of-multiple-sclerosis.pdf Abstract The clinical course of multiple sclerosis (MS)is highly variable. To esta...
by frodo
Tue Jan 26, 2021 12:56 pm
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: Two new ones related to EBV
Replies: 0
Views: 368

Biomarkers: Two new ones related to EBV

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients
https://www.sciencedirect.com/science/a ... 6421000049

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