Search found 1557 matches

by frodo
Tue Mar 16, 2021 10:55 am
Forum: MS Etiology and Pathogenesis
Topic: QSM-MRI can show brain inflammation.
Replies: 0
Views: 138

QSM-MRI can show brain inflammation.

QSM-MRI can show brain inflammation. Currently there is none. QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51338 Abstract Background: Inflammation in chronic active lesions occurs behind a closed bloo...
by frodo
Tue Mar 16, 2021 10:47 am
Forum: MS Etiology and Pathogenesis
Topic: MS transcriptome analysis
Replies: 1
Views: 154

Re: MS transcriptome analysis

looks like they are trying to separate RRMS from SPMS
by frodo
Mon Mar 08, 2021 8:32 pm
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers. Extensive review as of 2021
Replies: 0
Views: 161

Biomarkers. Extensive review as of 2021

https://www.sciencedirect.com/science/article/pii/S0960076021000637?casa_token=a5fL5oQjLCIAAAAA:j30jJv6tFVBDIzHlUixUFRnjwgaH8QwB6arVtvYOzPn3ZCapL5BaWI22-zaSxzW3njO6uiJwrw Biomarkers in Multiple sclerosis: what place for oxysterols? The main markers of multiple sclerosis that have been identified are...
by frodo
Mon Mar 08, 2021 8:17 pm
Forum: MS Etiology and Pathogenesis
Topic: MicroRNA in MS and other diseases
Replies: 0
Views: 154

MicroRNA in MS and other diseases

https://link.springer.com/article/10.1186/s41983-021-00289-1 MiRNA dysregulation multiple sclerosis MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to be consistently upregulated in MS patients including miR-142-3p, miR-145, miR-146a/b, miR-...
by frodo
Mon Mar 08, 2021 8:02 pm
Forum: MS Etiology and Pathogenesis
Topic: Teri helps recovering optic nerve
Replies: 0
Views: 152

Teri helps recovering optic nerve

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis https://journals.sagepub.com/doi/full/10.1177/1756286421997372 [...] Beneficial properties of TRF beyond pure peripheral immunomodulation have been hypothesized before. Preclinical data already indicated ben...
by frodo
Wed Feb 24, 2021 2:05 am
Forum: MS Etiology and Pathogenesis
Topic: TNF demyelination considered as MS
Replies: 0
Views: 207

TNF demyelination considered as MS

TNF-α blockers-associated multiple sclerosis https://www.sciencedirect.com/science/article/pii/S0165572821000527?casa_token=9YIL51DL-zUAAAAA:xr58vN7m305DukZ3s2nwNgTkMSeF4AzF9SPqh8QkIdK4VJEF1ofpsRA7TIYHlJCKzPB3em-Fdg Conclusion Our study confirmed that the exposure to TNFα blockers can be associated...
by frodo
Sat Feb 20, 2021 3:39 am
Forum: MS Etiology and Pathogenesis
Topic: EBV theory of MS. Some diagrams.
Replies: 1
Views: 219

EBV theory of MS. Some diagrams.

A new paper about how EBV could lead to MS. I link the main diagram here below. Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00035-6 https://marlin-prod.literatumonline.com/cms/attachment/2e9709c7-...
by frodo
Mon Feb 08, 2021 11:02 am
Forum: MS Etiology and Pathogenesis
Topic: The lancet: More about the previous two epitopes
Replies: 0
Views: 183

The lancet: More about the previous two epitopes

Serum markers of multiple sclerosis - a new approach https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00022-0/fulltext Optic neuritis (ON) typically manifests with the classical triad of subacute unilateral vision loss, periocular pain and impaired colour vision. It is the first sy...
by frodo
Mon Feb 08, 2021 10:55 am
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: Two epitopes predict ON evolution to MS
Replies: 0
Views: 190

Biomarkers: Two epitopes predict ON evolution to MS

You can see what a "epitope" is at wikipedia: https://en.wikipedia.org/wiki/Epitope Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients https://www.sciencedirect.com/science/article/pii/S2352396421000049 Background Optic neuritis (ON) can o...
by frodo
Mon Feb 08, 2021 10:51 am
Forum: MS Etiology and Pathogenesis
Topic: plasmablast: 100% specificity
Replies: 0
Views: 153

plasmablast: 100% specificity

Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases. https://www.sciencedirect.com/science/article/pii/S2211034820307938?casa_token=9UQB0NGWXccAAAAA:E3kzPWSfqYQuls1HU7l2L7lWjR32NlEuQEzkHxe_McrlhwkWaUY_4CGfF6t1x2zursWb5UjNzQ...
by frodo
Sat Jan 30, 2021 3:48 am
Forum: MS Etiology and Pathogenesis
Topic: A unified view of multiple sclerosis
Replies: 0
Views: 637

A unified view of multiple sclerosis

A unified view of multiple sclerosis https://www.researchgate.net/profile/David_Pitt7/publication/348734921_A_unified_view_of_multiple_sclerosis/links/600dbe8b92851c13fe355c81/A-unified-view-of-multiple-sclerosis.pdf Abstract The clinical course of multiple sclerosis (MS)is highly variable. To esta...
by frodo
Tue Jan 26, 2021 12:56 pm
Forum: MS Etiology and Pathogenesis
Topic: Biomarkers: Two new ones related to EBV
Replies: 0
Views: 351

Biomarkers: Two new ones related to EBV

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients
https://www.sciencedirect.com/science/a ... 6421000049
by frodo
Fri Jan 22, 2021 10:59 pm
Forum: MS Etiology and Pathogenesis
Topic: Nature: MRI can show biological heterogeneity
Replies: 0
Views: 309

Nature: MRI can show biological heterogeneity

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients https://www.nature.com/articles/s41598-021-81035-8 Abstract Magnetization transfer ratio (MTR) and brain volumetric imaging are (semi-)quantitative MRI markers capturing demyelination, axonal degeneration an...
by frodo
Fri Jan 22, 2021 10:52 pm
Forum: MS Etiology and Pathogenesis
Topic: Ibudilast for PPMS better than for SPMS
Replies: 0
Views: 278

Ibudilast for PPMS better than for SPMS

Response to ibudilast treatment according to progressive multiple sclerosis disease phenotype https://onlinelibrary.wiley.com/doi/full/10.1002/acn3.51251 Discussion The impetus to study ibudilast in progressive MS derived from the trial of ibudilast in relapsing MS.9 Although that study failed to d...

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