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Infrared spectral profiling of demyelinating activity in MS https://link.springer.com/article/10.1186/s40478-024-01854-4 Abstract Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. The highly dynamic nature of MS lesions has made them difficult to study using tr...

Contribution of Slow-Burning Inflammation and Chronic Demyelination to Axonal Damage https://www.msard-journal.com/article/S2211-0348(24)00405-X/abstract Highlights • Chronic expanding lesions showed a significantly higher rate of progressive tissue rarefication inside lesion core, as measured by n...

Paramagnetic Rim Lesions are Highly Specific for Multiple Sclerosis https://www.medrxiv.org/content/10.1101/2024.08.14.24312000v1 Background Paramagnetic rim lesions (PRL) are an emerging biomarker for multiple sclerosis (MS). In addition to associating with greater disease severity, PRL may be dia...

Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage

https://jnnp.bmj.com/content/95/4/325.abstract

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Beneficial therapeutic plasma exchange response in the treatment of severe relapses https://link.springer.com/article/10.1007/s13760-024-02606-w Abstract Purpose Therapeutic plasma exchange (PLEX) is effective as a second-line treatment of severe relapses of multiple sclerosis (MS) that failed to re...

Ineffective control of Epstein–Barr virus infection is seen in MS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883233/ The cause of multiple sclerosis (MS) is not known. Incidence and prevalence rates differ in the various regions of the world. 1 Migration studies have shown that age at migration ...

Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS https://jnnp.bmj.com/content/95/4/325.abstract Abstract Background : Multiple sclerosis (MS) and presymptomatic axonal injury appear to develop only after an Epstein-Barr virus (EBV) i...

Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awae244/7716181 Abstract Epstein-Barr virus (EBV) infection has long been associated with the development of multiple sclerosis (MS). ...

Cerebrospinal Fluid-In Gradient of Cortical and Deep Gray Matter Damage in Multiple Sclerosis https://www.neurology.org/doi/full/10.1212/NXI.0000000000200271 Background and Objectives A CSF-in gradient in cortical and thalamic gray matter (GM) damage has been found in multiple sclerosis (MS). We co...

Identification of brain-enriched proteins in CSF as biomarkers of relapsing remitting multiple sclerosis https://link.springer.com/article/10.1186/s12014-024-09494-5 Results We report 30 proteins with some relevance to disease, clinical subtype, or severity. Strikingly, we observed widespread prote...

A simplified method for relapsing-remitting multiple sclerosis detection: Insights from resting EEG signals https://www.sciencedirect.com/science/article/abs/pii/S0010482524008138 Highlights • Introduction of the first healthy-MS classification method achieving 100% accuracy using only two channels...

Finding an elusive predictive MS biomarker https://www.science.org/doi/full/10.1126/sciimmunol.adq7284 Abstract Whole-proteome autoantibody profiling reveals an immunological signature that predates the clinical onset of multiple sclerosis. Several studies indicate that the biological and clinical ...

An autoantibody signature predictive for multiple sclerosis https://www.nature.com/articles/s41591-024-02938-3 Abstract Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum...

Autoantibody Profile Emerged Years Before Multiple Sclerosis Diagnosis https://jamanetwork.com/journals/jama/article-abstract/2819074 About 10% of people with multiple sclerosis (MS) had an autoantibody signature that was present at least 5 years before symptoms, according to an analysis of blood s...

Optical coherence tomography angiography suggests different retinal pathologies https://link.springer.com/article/10.1007/s00415-024-12414-0 Abstract Background While retinal vessel changes are evident in the eyes of patients with relapsing–remitting multiple sclerosis (RRMS), changes in the vascul...