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Dear Mladen, Sorry for the late response. I agree with what you had written in your last posting. I think you misunderstood, or perhaps I did not explain the bucket model as I should have, and I think this led to some confusion. I won't go through this again as I think it will get too complicated. I...

Very interesting finding. I came across a similar but more recent study done in 1999.

http://www.ncbi.nlm.nih.gov/pubmed/20088446

North

Dear Malden, I see a number of flaws in your argument. Bucket model for the explain stenosis you suggest to use is not the "one tube is very large and one tube is tiny", it is "tubes are the same size, but one tube is narrowed (tiny) somewhere in the tube This argument makes absolulte...

Deer Cheerleader, Thank you for sharing this very interesting article with me. Until now, I assumed that the coagulation cascade was actived because of reduced blood flow or stasis, but after reading this study, hypoxia seems to be a more likely culprit. I realized that stasis cannot happen without ...

Dear Mladen, I feel like I am back in highschool physics class. It's making my brain work. Thanks for you responses. I am still, however, convinced that you are not correct in your analysis. What you explained with your pressure volume relationship makes sense in your closed system. At the point of ...

Dear Mladen, In reference to your comment: "This is not the only way. To keep flow on 25 cars/second in one line, you can speed up trafic in that one line five times! The trafic in the town remain the same." But how do you increase the the speed of the traffic 5 times? This will not happen...

Malden, You are correct. Perhaps I should have specified the supporting evidence was just for points 3-8. North Tx. North52, then let me present some unsuporting evidence for point no. 2: 2) This obstruction of the larger veins in turn results in reduced rate and velocity of flow in the microvascul...

Malden,

You are correct. Perhaps I should have specified the supporting evidence was just for points 3-8.

North

I thought it was contradictory initially as well. But after a bit of thought it wasn't. Here's my reasoning: What I stated was that there was active fibrinolysis in pregnancy. I suspect this happens in the small vessels where fibrin is formed and results in fewer ms lesions and symptoms. During fibr...

Dear LR1234, I agree with you and do not believe heparin will solve all problems. Relieving stenosis, however, might. I think drugs like heparin can partially help in those with existing outflow obstruction. One supplement that I think might help is nattokinase. This is a fibrinolytic that assists i...

The reduction of MS relapses in preganancy is a well documented phenomenon and the reasons for it are not known. I propose that it is secondary to increased fibrinolytic activity during pregnancy. Fibrinolytic activity is the bloods ability to break down fibrin. I a prevous post, I explain how fibri...

Im not sure if an experience I had last year supports your theory but. This was a few weeks before I went and got steroids for a relapse, I was worsening. I went home one evening feeling normal but a couple of hours after my betaferon injection I started to feel ill. I dont usually react to the int...

If indeed hypoperfusion does result in the breakdown of the BBB, why would the inflammation seen in the relapsing remitting stages of the disease subside after a number of years, as is seen when the disease enters its SPMS phase? Logic would seem to dictate that the continued effects of hypoperfusi...

I would like to propose a model for MS and CCSVI that implicates fibrin/fibrinogen as a mediator of the inflammary reaction. The first 8 points describe the hypothesis and the following text provides some supporting evidence for it. It gets quite technical. Microvascular Hypercoagulability Model for...

My understanding is that reflux is a key component to the CCSVI hypothesis, in that it explains the breakdown in the blood brain barrier that allows for the immunological response that is a hallmark of MS. A simple reduction in blood flow, while certainly capable of doing harm to the CNS over the c...