Search found 15 matches

by rndlph
Sun Dec 05, 2004 9:21 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Tysabri: Fine Young Cannibal or CRAB's New Partner in Crime
Replies: 7
Views: 3874

MS, I will not see my neurologist until after the holidays, so I don't yet know what she thinks. It should be interesting. She believes in aggressive treatment. Your take on combination therapy seems similar to mine. I just wonder what result Biogen was hoping to see in SENTINEL. I mean, would they ...
by rndlph
Sat Dec 04, 2004 10:35 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Tysabri: Fine Young Cannibal or CRAB's New Partner in Crime
Replies: 7
Views: 3874

Tysabri: Fine Young Cannibal or CRAB's New Partner in Crime

I would like to hear some discussion on the possible meaning of the one-year SENTINEL trial information that was recently released. Right now, I am leaning toward pushing for combination therapy when I make the leap to Tysabri. But I would really like to be talked out of continuing the Avonex. The s...
by rndlph
Sat Dec 04, 2004 10:21 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

Re: control groups to the rescue?

The ONLY reason that steroids would be administered to a MS patient in a trial would be if the patient was experiencing an exacerbation. Steroids can have quite an effect on a patient and can certainly effect their overall reaction to the drug that they are using in the trial. They can mask symptom...
by rndlph
Sat Dec 04, 2004 9:46 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

putting out fires with gasoline

My Dear Observer, Regarding your point 1, this statement was used to respond to some rather heated words addressed directly to me by OddDuck. I think I deserved some latitude here, but opinions apparently differ. These comments, like yours, are procedural in nature. Granted, these should be limited,...
by rndlph
Sat Dec 04, 2004 8:14 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

control groups to the rescue?

If Tysabri reduced exacerbations by 66% without the help of steroids and this number holds true throughout the entire Phase III trials, then that would be great....but I guess we'll just have to wait and see. Why does it matter if steroids were administered or not? In a double-blind study, the ster...
by rndlph
Sat Dec 04, 2004 7:11 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

Dave, Just when we think some order has returned to the discussion, you find it necessary to start taking "shots" at someone again!! Please, do us all a favor and leave the personal angle out of this. Thank you. Harry Ah, order--the hallmark of a one-sided conversation. Sorry to have interrupted th...
by rndlph
Sat Dec 04, 2004 7:02 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

personal identifying information?

Dear OddDuck,

What "personal identifying information" are you talking about? Everything I know about you came from this forum. Are you asking me not to repeat things that you have said about yourself?

Thanks,
Dave
by rndlph
Sat Dec 04, 2004 6:53 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

never mind

All of my comments specifically address OddDuck's statements. I never called anyone a liar. I am starting to question some of your reading skills, but I am not questioning anyone's honesty. Apparently critical thought is not valued in this forum. If it is not self-congratulatory or fawning, it is "n...
by rndlph
Sat Dec 04, 2004 2:12 am
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

OddDuck, I am utterly amazed that someone who has posted over 10% of the content in this public discussion forum could have such thin skin. Moreover, you really should read more carefully. Or are you just being obtuse for snide effect? Here we go again. You can stop with the tone and hateful words t...
by rndlph
Sun Nov 28, 2004 8:48 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Antegren/Tysabri approved!
Replies: 120
Views: 24183

Another take on the label

I also read the new Tysabri label with great interest, but was far less frustrated by it than OddDuck appears to have been. OddDuck: Data from an experimental autoimmune encephalitis animal model of multiple sclerosis Isn't EAE suspect itself as to whether or not it is even a good model for human MS...
by rndlph
Sat Sep 25, 2004 9:16 am
Forum: General Discussion
Topic: Lhermitte's sign
Replies: 2
Views: 3217

lesion

I have a cervical lesion and do not have this sign. There really is very little clear mapping of MRI findings to specific symptoms.
by rndlph
Tue Aug 10, 2004 8:40 pm
Forum: Copaxone
Topic: Copaxone info
Replies: 5
Views: 3702

hearsay

The testimony of the unnamed doctor of an unnamed "lady" notwithstanding, I will wait for the Phase III trial results on Antegren and remain optimistic.
by rndlph
Thu Aug 05, 2004 2:16 pm
Forum: Introductions
Topic: Another hello - this one from Limbo
Replies: 5
Views: 2596

Diagnosed last October

I was diagnosed last October, and have been on Avonex since last November. So far, all has been quiet, though I still have some numbness and stiffness in my left arm from the first (?) attack. I think I am going to be stuck with that for the duration. About seven years ago, I was diagnosed with an "...
by rndlph
Wed Aug 04, 2004 6:05 pm
Forum: Tysabri (Antegren or Natalizumab)
Topic: Early approval for Antegren
Replies: 7
Views: 3802

Hope

I have extremely high hopes about Antegren, as my understanding is that it has a very good side effect profile. I focus on side effects for two reasons. First, the side effects I experience with Avonex vary from bad to horrible--worse than anything MS has ever done to me. It would be great not to ha...
by rndlph
Wed Aug 04, 2004 5:41 pm
Forum: Introductions
Topic: Another hello - this one from Limbo
Replies: 5
Views: 2596

these go to eleven

Absalom, I took a look at your journal. I think you should press your new neurologist for a spinal tap. One of the benefits of being male is that the risk of a dreaded spinal headache is remote. And the diagnostic value of the spinal tap is very high. My first neurologist gave me the same line about...

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