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MS, I will not see my neurologist until after the holidays, so I don't yet know what she thinks. It should be interesting. She believes in aggressive treatment. Your take on combination therapy seems similar to mine. I just wonder what result Biogen was hoping to see in SENTINEL. I mean, would they ...

I would like to hear some discussion on the possible meaning of the one-year SENTINEL trial information that was recently released. Right now, I am leaning toward pushing for combination therapy when I make the leap to Tysabri. But I would really like to be talked out of continuing the Avonex. The s...

The ONLY reason that steroids would be administered to a MS patient in a trial would be if the patient was experiencing an exacerbation. Steroids can have quite an effect on a patient and can certainly effect their overall reaction to the drug that they are using in the trial. They can mask symptom...

My Dear Observer, Regarding your point 1, this statement was used to respond to some rather heated words addressed directly to me by OddDuck. I think I deserved some latitude here, but opinions apparently differ. These comments, like yours, are procedural in nature. Granted, these should be limited,...

If Tysabri reduced exacerbations by 66% without the help of steroids and this number holds true throughout the entire Phase III trials, then that would be great....but I guess we'll just have to wait and see. Why does it matter if steroids were administered or not? In a double-blind study, the ster...

Dave, Just when we think some order has returned to the discussion, you find it necessary to start taking "shots" at someone again!! Please, do us all a favor and leave the personal angle out of this. Thank you. Harry Ah, order--the hallmark of a one-sided conversation. Sorry to have inte...

Dear OddDuck,

What "personal identifying information" are you talking about? Everything I know about you came from this forum. Are you asking me not to repeat things that you have said about yourself?

Thanks,
Dave

All of my comments specifically address OddDuck's statements. I never called anyone a liar. I am starting to question some of your reading skills, but I am not questioning anyone's honesty. Apparently critical thought is not valued in this forum. If it is not self-congratulatory or fawning, it is &q...

OddDuck, I am utterly amazed that someone who has posted over 10% of the content in this public discussion forum could have such thin skin. Moreover, you really should read more carefully. Or are you just being obtuse for snide effect? Here we go again. You can stop with the tone and hateful words t...

I also read the new Tysabri label with great interest, but was far less frustrated by it than OddDuck appears to have been. OddDuck: Data from an experimental autoimmune encephalitis animal model of multiple sclerosis Isn't EAE suspect itself as to whether or not it is even a good model for human MS...

I have a cervical lesion and do not have this sign. There really is very little clear mapping of MRI findings to specific symptoms.

The testimony of the unnamed doctor of an unnamed "lady" notwithstanding, I will wait for the Phase III trial results on Antegren and remain optimistic.

I was diagnosed last October, and have been on Avonex since last November. So far, all has been quiet, though I still have some numbness and stiffness in my left arm from the first (?) attack. I think I am going to be stuck with that for the duration. About seven years ago, I was diagnosed with an &...

I have extremely high hopes about Antegren, as my understanding is that it has a very good side effect profile. I focus on side effects for two reasons. First, the side effects I experience with Avonex vary from bad to horrible--worse than anything MS has ever done to me. It would be great not to ha...

Absalom, I took a look at your journal. I think you should press your new neurologist for a spinal tap. One of the benefits of being male is that the risk of a dreaded spinal headache is remote. And the diagnostic value of the spinal tap is very high. My first neurologist gave me the same line about...