Search found 2 matches
- Wed May 15, 2013 9:31 am
- Forum: Tecfidera (BG-12, Dimethyl fumarate)
- Topic: Tecfidera efficacy & potential toxicity
- Replies: 7
- Views: 7679
Re: Tecfidera efficacy & potential toxicity
I read the study and I took that to mean; in order to get a comparable plasma concentration of the metabolite monomethyl fumarate, MMF, rats had to be dosed, with dimethyl fumarate, at least 25 mg/kg/day. That is five times the dose of dimythel fumarate a 190 lb man would get taking tecfidera as pre...
- Tue May 14, 2013 7:14 am
- Forum: Tecfidera (BG-12, Dimethyl fumarate)
- Topic: Tecfidera efficacy & potential toxicity
- Replies: 7
- Views: 7679
Re: Tecfidera efficacy & potential toxicity
NHE, I don't think you understand what the study says. At "doses of 25, 75, 200, and 400 mg/kg/day" caused cancer in mice and rats. In my case, I weigh 87 kg, in order to take a comparable dose I would have to take a dose of 2175, 6525, 17400, and 34800 mg/day. This is significantly below ...