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There was a trial somewhere in central/eastern Europe on inosine -- is the group who wrote this paper the group that did the trial? No they are not connected as far as I know. Szabo et al. have published several reports regarding inosine and autoimmunity (pubmed search with "Szabo[auth] inosin...

Anybody know of any other drugs / supplements that could have a beneficial effect on IL-12 for PwMS? Inosine, used in recent trials by for example G. Toncev, Hooper et.al. to raise serum uric acid levels in MS patients, does according to the study below also inhibit IL-12 production. The original t...

What is pioglitazones' mode of action? PPAR-gamma agonists like pioglitazone seem to have a broad range of activity that could be beneficial in treating MS, so I guess that is why your question is a bit tricky. However, it seems to be pretty clear that PPAR-gamma agonists is "hot" science...

I've been following the research about uric acid and it's potentially protective role in MS for a couple of years now. The inosine trial you are referring should have started in 2002 and was to be ended in december 2004. Yet it is recruiting patients according to the website...Weird. :? I am just as...

You might also want to check out this thread at Thisisms.com: Pioglitazone . I added the post above in August 2004. Back then a trial had been initiated, involving 30 people and lasting for 18 months, which means we pretty soon should be able to get some results from it. Despite keeping an eye open ...

This is an absolutely ridiculous study. Firstly, you can manipulate statistics to prove anything and secondly I was born in November and I've got MS. I don't really understand the critisism of this study and this kind of study. First of all the study described an increased MS risk for babies born i...

Good question, which I believe is over looked by many. I think it is a must to have much knowledge of the BBB when doing private "MS research" like many of us are doing here. Independent of what paradigm of MS research you are into, you can always find something interesting about the endot...

The severity of MS symptoms often tend to vary a lot from day to day. I have posted in this subject before, because I find this phenomenon a bit strange and interesting. I'm particulary interested in what makes a rapid (hour to hour, day to day) difference on severity of symptoms. Feel free to post ...

Hi, have any of you ever experienced trouble with episcleritis? Episcleritis is a mild inflammatory condition of the outer layer of the sclera (white area of the eye), resulting in a red eye. Sometimes it is also associated with mild discomfort, pain etc. This is nothing serious at all, probably why...

We could go on and on. MS is all over the board. You can't make ANY one "statement" about MS, and find it to be unequivocally true in all cases. That's the problem. Well, maybe you can make one. You can isolate MS to affecting basically the central nervous system . I guess that tells us s...

Irreversible damage in SPMS yet reversible? I think it is interesting to discuss a few things, regarding the new treatments which have been reported to have an effect on SPMS. It is especially interesting when the treatment results in reversal of symptoms, like in the case of pioglitazone. Other ag...

I am curious. 400,000 people in the U.S. has MS. Out of the 400,0000, small portion probably developed type II diabetes and started taking this drug. Is this how they found out that Pioglitazone helped? No it doesn't seem so. Pioglitazone is a fairly new drug on the market. In Europe it has been us...

The substance used for treating diabetes mellitus type II, Pioglitazone, previously mentioned here on thisisms.com, has been tested on a single patient for three years. The patient had secondary progressive MS. The study concludes that " MRIs carried out after 10 and 18 months of treatment show...