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Longitudinal analysis: EBV is probably the cause of MS

Last post by frodo « Fri Jan 14, 2022 9:15 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jan 14, 2022 9:15 am » in MS Etiology and Pathogenesis

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Abstract

Multiple sclerosis (MS) is a...

0 Replies

45 Views

Last post by frodo
Fri Jan 14, 2022 9:15 am
Possible failure of natural apoptosis in MS

Last post by frodo « Thu Jan 13, 2022 8:03 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Jan 13, 2022 8:03 am » in MS Etiology and Pathogenesis

Apoptotic protease activating factor-1 gene and MicroRNA-484: A possible interplay in relapsing remitting multiple sclerosis

Abstract...

0 Replies

47 Views

Last post by frodo
Thu Jan 13, 2022 8:03 am
Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, distinguish MS

Last post by frodo « Tue Jan 11, 2022 12:24 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Jan 11, 2022 12:24 pm » in MS Etiology and Pathogenesis

Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders

Increased...

0 Replies

57 Views

Last post by frodo
Tue Jan 11, 2022 12:24 pm
Second chances

Last post by NHE « Wed Jan 05, 2022 1:20 pm
Posted in Humor

by NHE » Wed Jan 05, 2022 1:20 pm » in Humor

“If at first you don’t succeed...

so much for skydiving.”

0 Replies

121 Views

Last post by NHE
Wed Jan 05, 2022 1:20 pm
Dialysis like blood treatment called HELP apheresis

Last post by Cece « Wed Jan 05, 2022 8:46 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by Cece » Wed Jan 05, 2022 8:46 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

There's a treatment called HELP apheresis that filters microclots and inflammatory platelets out of the blood. I wonder if that could help in MS or...

0 Replies

103 Views

Last post by Cece
Wed Jan 05, 2022 8:46 am
Early OCT diagnosis: 100% specificity and sensitivity

Last post by frodo « Mon Jan 03, 2022 6:10 am
Posted in MS Etiology and Pathogenesis

by frodo » Mon Jan 03, 2022 6:10 am » in MS Etiology and Pathogenesis

Interestingly, there is no myelyn in the retina.

Early Diagnosis of Multiple Sclerosis Using Swept-Source Optical Coherence Tomography and...

0 Replies

108 Views

Last post by frodo
Mon Jan 03, 2022 6:10 am
40 Hz Light Flicker

Last post by Petr75 « Fri Dec 31, 2021 6:33 am
Posted in General Discussion

by Petr75 » Fri Dec 31, 2021 6:33 am » in General Discussion

2021 Dec 13
Brain Research Centre and Department of Biology, Southern University of Science and Technology, Shenzhen, China
40 Hz Light Flicker...

0 Replies

110 Views

Last post by Petr75
Fri Dec 31, 2021 6:33 am
Glymphatic system and MS

Last post by frodo « Thu Dec 30, 2021 1:34 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Dec 30, 2021 1:34 am » in MS Etiology and Pathogenesis

Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability

Abstract

Recent evidences showed the existence...

0 Replies

96 Views

Last post by frodo
Thu Dec 30, 2021 1:34 am
Prescribing Information

Last post by NHE « Tue Dec 28, 2021 11:40 am
Posted in General Medications

by NHE » Tue Dec 28, 2021 11:40 am » in General Medications

Prescribing information for general medications commonly used by MS patients.

Note: Let me know if there are additional medications you would like...

0 Replies

174 Views

Last post by NHE
Tue Dec 28, 2021 11:40 am
Father Christmas

Last post by ArthurJ « Sun Dec 26, 2021 4:42 pm
Posted in Daily Life

by ArthurJ » Sun Dec 26, 2021 4:42 pm » in Daily Life

“It just kept on raining...”

0 Replies

179 Views

Last post by ArthurJ
Sun Dec 26, 2021 4:42 pm
CDP-choline for remyelination

Last post by DIM « Mon Dec 20, 2021 3:12 pm
Posted in General Discussion

by DIM » Mon Dec 20, 2021 3:12 pm » in General Discussion

0 Replies

167 Views

Last post by DIM
Mon Dec 20, 2021 3:12 pm
Glymphatic system

Last post by Petr75 « Sat Dec 18, 2021 10:22 am
Posted in General Discussion

by Petr75 » Sat Dec 18, 2021 10:22 am » in General Discussion

2021 Dec 17
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy
Glymphatic system impairment...

0 Replies

138 Views

Last post by Petr75
Sat Dec 18, 2021 10:22 am
Meditation

Last post by Petr75 « Thu Dec 16, 2021 1:01 pm
Posted in General Discussion

by Petr75 » Thu Dec 16, 2021 1:01 pm » in General Discussion

2021 Dec 21
Department of Pediatrics, College of Medicine, University of Florida, Gainesville
Large-scale genomic study reveals robust activation of...

0 Replies

138 Views

Last post by Petr75
Thu Dec 16, 2021 1:01 pm
Dementia risks with anticholinergic medications

Last post by NHE « Wed Dec 15, 2021 2:27 pm
Posted in General Medications

by NHE » Wed Dec 15, 2021 2:27 pm » in General Medications

Many medications that MS patients take, e.g., baclofen and tizanidine, contain drugs that have been reported to have anticholinergic activity. In...

0 Replies

202 Views

Last post by NHE
Wed Dec 15, 2021 2:27 pm
VISTA

Last post by Petr75 « Wed Dec 15, 2021 11:02 am
Posted in General Discussion

by Petr75 » Wed Dec 15, 2021 11:02 am » in General Discussion

2021 May 18
Department of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University Medical Center Groningen, University...

0 Replies

162 Views

Last post by Petr75
Wed Dec 15, 2021 11:02 am
Nature: NODDI reveals brain microstructural changes in multiple sclerosis

Last post by frodo « Wed Dec 15, 2021 12:22 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Dec 15, 2021 12:22 am » in MS Etiology and Pathogenesis

NODDI reveals brain microstructural changes in multiple sclerosis

A new study shows that neurite orientation dispersion and density imaging...

0 Replies

190 Views

Last post by frodo
Wed Dec 15, 2021 12:22 am
Treg engineers take aim at autoimmunity

Last post by jimmylegs « Sat Dec 11, 2021 1:41 am
Posted in Drug Pipeline

by jimmylegs » Sat Dec 11, 2021 1:41 am » in Drug Pipeline

interesting:

Treg engineers take aim at autoimmunity (2021)

These souped-up cell therapies, if successful, should create a type of...

0 Replies

234 Views

Last post by jimmylegs
Sat Dec 11, 2021 1:41 am
Update about patterns, Nov. 2021

Last post by frodo « Thu Dec 09, 2021 11:39 am
Posted in MS Etiology and Pathogenesis

by frodo » Thu Dec 09, 2021 11:39 am » in MS Etiology and Pathogenesis

Clinical Correlation of Multiple Sclerosis Immunopathologic Subtypes

Abstract

Background and Objectives

The goal of this work was to...

0 Replies

196 Views

Last post by frodo
Thu Dec 09, 2021 11:39 am
B cells as disease-drivers and therapeutic targets

Last post by jimmylegs « Sun Dec 05, 2021 7:14 am
Posted in MS Etiology and Pathogenesis

by jimmylegs » Sun Dec 05, 2021 7:14 am » in MS Etiology and Pathogenesis

getting up to speed on a few topics :) i've been interested in b10 cells lately.

Update on the autoimmune pathology of multiple sclerosis: B cells...

0 Replies

211 Views

Last post by jimmylegs
Sun Dec 05, 2021 7:14 am
Baclofen cautions

Last post by NHE « Sat Dec 04, 2021 6:20 pm
Posted in General Medications

by NHE » Sat Dec 04, 2021 6:20 pm » in General Medications

The Mayo Clinic reports that withdrawal from baclofen must be done in a tapered protocol in order to avoid severe side effects as discussed below....

0 Replies

241 Views

Last post by NHE
Sat Dec 04, 2021 6:20 pm
Vitamin D3 acts as an antioxidant

Last post by NHE « Wed Dec 01, 2021 12:36 pm
Posted in Natural Approach

by NHE » Wed Dec 01, 2021 12:36 pm » in Natural Approach

Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS
Ann N Y Acad Sci. 2005 Aug;1053:319-29.

Antioxidative mechanisms of...

0 Replies

175 Views

Last post by NHE
Wed Dec 01, 2021 12:36 pm
Towards Comprehensive MS Theory

Last post by jimmylegs « Sun Nov 28, 2021 5:39 am
Posted in General Discussion

by jimmylegs » Sun Nov 28, 2021 5:39 am » in General Discussion

Towards a comprehensive etiopathogenetic and pathophysiological theory of multiple sclerosis

... Conclusions: For better MS prevention and...

0 Replies

235 Views

Last post by jimmylegs
Sun Nov 28, 2021 5:39 am
Nutrition, Exercise, MS

Last post by jimmylegs « Sun Nov 28, 2021 1:56 am
Posted in General Discussion

by jimmylegs » Sun Nov 28, 2021 1:56 am » in General Discussion

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

... Among the...

0 Replies

213 Views

Last post by jimmylegs
Sun Nov 28, 2021 1:56 am
more about HERVs and HERV-W

Last post by frodo « Fri Nov 26, 2021 2:44 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Nov 26, 2021 2:44 am » in MS Etiology and Pathogenesis

This is a review. There is nothing new, but it is interesting to read:

Human Endogenous Retrovirus and Multiple Sclerosis: a review and...

0 Replies

196 Views

Last post by frodo
Fri Nov 26, 2021 2:44 am
Melatonin inhibits neuroinflammation

Last post by NHE « Thu Nov 25, 2021 8:49 am
Posted in Natural Approach

by NHE » Thu Nov 25, 2021 8:49 am » in Natural Approach

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Tahir Ali et al. J...

0 Replies

195 Views

Last post by NHE
Thu Nov 25, 2021 8:49 am
PI3K/Akt

Last post by Petr75 « Thu Nov 25, 2021 4:58 am
Posted in General Discussion

by Petr75 » Thu Nov 25, 2021 4:58 am » in General Discussion

2021 Nov 20
Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael's...

0 Replies

216 Views

Last post by Petr75
Thu Nov 25, 2021 4:58 am
p21-activated kinases (PAKs)

Last post by Petr75 « Thu Nov 25, 2021 4:40 am
Posted in General Discussion

by Petr75 » Thu Nov 25, 2021 4:40 am » in General Discussion

2021 Nov 22
Department of Neurology, Shriners Hospitals for Children/School of Medicine, Institute for Pediatric Regenerative Medicine (IPRM),...

0 Replies

208 Views

Last post by Petr75
Thu Nov 25, 2021 4:40 am
Epstein-Barr virus nuclear antigen 2 extensively rewires the human chromatin landscape at autoimmune risk loci

Last post by Tif « Mon Nov 22, 2021 9:00 am
Posted in MS Etiology and Pathogenesis

by Tif » Mon Nov 22, 2021 9:00 am » in MS Etiology and Pathogenesis

The interplay between environmental and genetic factors plays a key role in the development of many autoimmune diseases. In particular, the...

0 Replies

194 Views

Last post by Tif
Mon Nov 22, 2021 9:00 am
BCI-FES

Last post by Petr75 « Tue Nov 16, 2021 12:10 pm
Posted in General Discussion

by Petr75 » Tue Nov 16, 2021 12:10 pm » in General Discussion

2021 Nov 15
Universidad Nacional de Entre Ríos Facultad de Ingeniería, ARGENTINA
Effects of brain-computer interface with functional electrical...

0 Replies

236 Views

Last post by Petr75
Tue Nov 16, 2021 12:10 pm
Monovaccine (Epstein - Barr virus) Market Overview 2021

Last post by Tif « Tue Nov 16, 2021 10:26 am
Posted in MS Etiology and Pathogenesis

by Tif » Tue Nov 16, 2021 10:26 am » in MS Etiology and Pathogenesis

Hi,

SEATTLE, WASHINGTON, UNITED STATES, November 16, 2021 /EINPresswire.com/ -- The increasing research and development activities and funding...

0 Replies

217 Views

Last post by Tif
Tue Nov 16, 2021 10:26 am
MedDay High-dose Biotin Fails Clinical Trial

Last post by NHE « Sun Nov 14, 2021 8:52 am
Posted in Biotin (Qizenday, Cerenday, MD1003)

by NHE » Sun Nov 14, 2021 8:52 am » in Biotin (Qizenday, Cerenday, MD1003)

Negative Results of High Dose Biotin (MD1003) Clinical Trial Published

October 29, 2020

A large Phase 3 clinical trial of high-dose Biotin...

0 Replies

238 Views

Last post by NHE
Sun Nov 14, 2021 8:52 am
Qunol Sleep?

Last post by NHE « Sat Nov 13, 2021 1:33 pm
Posted in Natural Approach

by NHE » Sat Nov 13, 2021 1:33 pm » in Natural Approach

I’m having difficulty getting regular sleep. I’ve used melatonin and have also combined it with gaba. Sometimes the combo helps, more often it...

0 Replies

184 Views

Last post by NHE
Sat Nov 13, 2021 1:33 pm
CBD Attenuates Neuroinflammation

Last post by NHE « Thu Nov 11, 2021 3:38 pm
Posted in Medical Marijuana

by NHE » Thu Nov 11, 2021 3:38 pm » in Medical Marijuana

Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune...

0 Replies

228 Views

Last post by NHE
Thu Nov 11, 2021 3:38 pm
Emotion

Last post by Petr75 « Wed Nov 10, 2021 10:46 pm
Posted in General Discussion

by Petr75 » Wed Nov 10, 2021 10:46 pm » in General Discussion

2021 Nov 8
University of Strasbourg and French National Centre for Scientific Research (CNRS), ICube Laboratory UMR 7357 and FMTS (Fédération de...

0 Replies

203 Views

Last post by Petr75
Wed Nov 10, 2021 10:46 pm
Smartphone

Last post by Petr75 « Mon Nov 01, 2021 9:11 am
Posted in General Discussion

by Petr75 » Mon Nov 01, 2021 9:11 am » in General Discussion

2021 Oct 31
Smartphone-derived keystroke dynamics are sensitive to relevant changes in multiple sclerosis

Abstract

Background: To investigate...

0 Replies

439 Views

Last post by Petr75
Mon Nov 01, 2021 9:11 am
A Study to Evaluate Tabelecleucel in Participants With Epstein-barr Virus-associated Diseases

Last post by Tif « Sun Oct 31, 2021 10:12 am
Posted in MS Etiology and Pathogenesis

by Tif » Sun Oct 31, 2021 10:12 am » in MS Etiology and Pathogenesis

ClinicalTrials.gov Identifier: NCT04554914

0 Replies

510 Views

Last post by Tif
Sun Oct 31, 2021 10:12 am
Safety and Immunogenicity of an Epstein-Barr Virus (EBV) gp350-Ferritin Nanoparticle Vaccine in Healthy Adults With or W

Last post by Tif « Sat Oct 30, 2021 12:45 pm
Posted in MS Etiology and Pathogenesis

by Tif » Sat Oct 30, 2021 12:45 pm » in MS Etiology and Pathogenesis

.... on October 27,2021 NIH began enrolling volunteers in a four-year clinical trial to test the safety of and immune response to a vaccine against...

0 Replies

446 Views

Last post by Tif
Sat Oct 30, 2021 12:45 pm
microstructural and metabolic alterations

Last post by frodo « Wed Oct 13, 2021 4:38 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:38 am » in MS Etiology and Pathogenesis

Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event

Abstract

In early multiple...

0 Replies

372 Views

Last post by frodo
Wed Oct 13, 2021 4:38 am
soluble factors released from meningeal inflammation as the culprit

Last post by frodo « Wed Oct 13, 2021 4:34 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:34 am » in MS Etiology and Pathogenesis

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Abstract

While multiple sclerosis can affect any part of the CNS, it...

0 Replies

367 Views

Last post by frodo
Wed Oct 13, 2021 4:34 am
Ofatumumab has the best efficacy

Last post by frodo « Tue Oct 12, 2021 11:53 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:53 pm » in MS Etiology and Pathogenesis

Emerging data on the treatment of multiple sclerosis

Background and objectives. In the past few years, a myriad of new studies were aimed to find...

0 Replies

376 Views

Last post by frodo
Tue Oct 12, 2021 11:53 pm
anti-CD20 MABs work by depleting EBV load

Last post by frodo « Tue Oct 12, 2021 11:46 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:46 pm » in MS Etiology and Pathogenesis

The cellular immune response against Epstein-Barr virus decreases during ocrelizumab treatment.
Mult Scler Relat Disord. 2021 Sep 28;56:103282. doi:...

0 Replies

382 Views

Last post by frodo
Tue Oct 12, 2021 11:46 pm
Two statistical clusters of lesions

Last post by frodo « Tue Oct 05, 2021 4:32 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:32 am » in MS Etiology and Pathogenesis

Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients

Abstract

Background : Magnetic resonance imaging...

0 Replies

396 Views

Last post by frodo
Tue Oct 05, 2021 4:32 am
Prodrome: White matter abnormalities before lesions

Last post by frodo « Tue Oct 05, 2021 4:22 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:22 am » in MS Etiology and Pathogenesis

Machine learning to investigate superficial white matter integrity in early multiple sclerosis

Abstract

Background and Purpose

This study...

0 Replies

389 Views

Last post by frodo
Tue Oct 05, 2021 4:22 am
older ppl, attitudes, status

Last post by jimmylegs « Sat Sep 25, 2021 9:13 am
Posted in Diet

by jimmylegs » Sat Sep 25, 2021 9:13 am » in Diet

Older Adults Who Use Vitamin/Mineral Supplements Differ from Nonusers in Nutrient Intake Adequacy and Dietary Attitudes

Conclusions

A large...

0 Replies

497 Views

Last post by jimmylegs
Sat Sep 25, 2021 9:13 am
Microglia clean up toxic lipids in multiple sclerosis

Last post by frodo « Fri Sep 24, 2021 12:45 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Sep 24, 2021 12:45 am » in MS Etiology and Pathogenesis

Microglia clean up toxic lipids in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and...

0 Replies

425 Views

Last post by frodo
Fri Sep 24, 2021 12:45 am
Genome Wide Associated Study: Genes involved in lesion locations

Last post by frodo « Thu Sep 23, 2021 11:39 pm
Posted in MS Etiology and Pathogenesis

by frodo » Thu Sep 23, 2021 11:39 pm » in MS Etiology and Pathogenesis

The authors propose that some existing drugs could be repurposed to target each the genetic pathway.

An integrative study of genetic variants with...

0 Replies

396 Views

Last post by frodo
Thu Sep 23, 2021 11:39 pm
getting DRIs right

Last post by jimmylegs « Thu Sep 23, 2021 11:18 am
Posted in Diet

by jimmylegs » Thu Sep 23, 2021 11:18 am » in Diet

aha, 'my people'! ;)

Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored...

0 Replies

350 Views

Last post by jimmylegs
Thu Sep 23, 2021 11:18 am
Lenabasum

Last post by Petr75 « Tue Sep 21, 2021 5:20 am
Posted in Medical Marijuana

by Petr75 » Tue Sep 21, 2021 5:20 am » in Medical Marijuana

2021 Sep 20
Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy
Potent T cell mediated anti-inflammatory role...

0 Replies

335 Views

Last post by Petr75
Tue Sep 21, 2021 5:20 am
Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Last post by frodo « Fri Sep 17, 2021 3:01 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Fri Sep 17, 2021 3:01 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Summary

The theory that multiple sclerosis is...

0 Replies

543 Views

Last post by frodo
Fri Sep 17, 2021 3:01 am
central vein sign and iron in lesion as biomarkers

Last post by frodo « Wed Sep 15, 2021 11:02 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Wed Sep 15, 2021 11:02 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis

Introduction

Susceptibility-based...

0 Replies

419 Views

Last post by frodo
Wed Sep 15, 2021 11:02 am

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