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ATA188

Last post by tzootsi « Fri Oct 15, 2021 7:23 am
Posted in Drug Pipeline

by tzootsi » Fri Oct 15, 2021 7:23 am » in Drug Pipeline

0 Replies

11 Views

Last post by tzootsi
Fri Oct 15, 2021 7:23 am
iron-rim lesions importance

Last post by frodo « Wed Oct 13, 2021 4:47 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:47 am » in MS Etiology and Pathogenesis

Iron-rim lesions are probably the same than smouldering lesions.

Association of iron rim lesions with brain and cervical cord volume in relapsing...

0 Replies

27 Views

Last post by frodo
Wed Oct 13, 2021 4:47 am
microstructural and metabolic alterations

Last post by frodo « Wed Oct 13, 2021 4:38 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:38 am » in MS Etiology and Pathogenesis

Brain microstructural and metabolic alterations detected in vivo at onset of the first demyelinating event

Abstract

In early multiple...

0 Replies

16 Views

Last post by frodo
Wed Oct 13, 2021 4:38 am
soluble factors released from meningeal inflammation as the culprit

Last post by frodo « Wed Oct 13, 2021 4:34 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Oct 13, 2021 4:34 am » in MS Etiology and Pathogenesis

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Abstract

While multiple sclerosis can affect any part of the CNS, it...

0 Replies

12 Views

Last post by frodo
Wed Oct 13, 2021 4:34 am
Ofatumumab has the best efficacy

Last post by frodo « Tue Oct 12, 2021 11:53 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:53 pm » in MS Etiology and Pathogenesis

Emerging data on the treatment of multiple sclerosis

Background and objectives. In the past few years, a myriad of new studies were aimed to find...

0 Replies

23 Views

Last post by frodo
Tue Oct 12, 2021 11:53 pm
anti-CD20 MABs work by depleting EBV load

Last post by frodo « Tue Oct 12, 2021 11:46 pm
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 12, 2021 11:46 pm » in MS Etiology and Pathogenesis

The cellular immune response against Epstein-Barr virus decreases during ocrelizumab treatment.
Mult Scler Relat Disord. 2021 Sep 28;56:103282. doi:...

0 Replies

20 Views

Last post by frodo
Tue Oct 12, 2021 11:46 pm
Two statistical clusters of lesions

Last post by frodo « Tue Oct 05, 2021 4:32 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:32 am » in MS Etiology and Pathogenesis

Lesion features on magnetic resonance imaging discriminate multiple sclerosis patients

Abstract

Background : Magnetic resonance imaging...

0 Replies

64 Views

Last post by frodo
Tue Oct 05, 2021 4:32 am
Prodrome: White matter abnormalities before lesions

Last post by frodo « Tue Oct 05, 2021 4:22 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Oct 05, 2021 4:22 am » in MS Etiology and Pathogenesis

Machine learning to investigate superficial white matter integrity in early multiple sclerosis

Abstract

Background and Purpose

This study...

0 Replies

44 Views

Last post by frodo
Tue Oct 05, 2021 4:22 am
Nervgen remyelination drug phase 1

Last post by DIM « Sun Oct 03, 2021 9:08 am
Posted in Drug Pipeline

by DIM » Sun Oct 03, 2021 9:08 am » in Drug Pipeline

0 Replies

143 Views

Last post by DIM
Sun Oct 03, 2021 9:08 am
older ppl, attitudes, status

Last post by jimmylegs « Sat Sep 25, 2021 9:13 am
Posted in Diet

by jimmylegs » Sat Sep 25, 2021 9:13 am » in Diet

Older Adults Who Use Vitamin/Mineral Supplements Differ from Nonusers in Nutrient Intake Adequacy and Dietary Attitudes

Conclusions

A large...

0 Replies

79 Views

Last post by jimmylegs
Sat Sep 25, 2021 9:13 am
Microglia clean up toxic lipids in multiple sclerosis

Last post by frodo « Fri Sep 24, 2021 12:45 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Sep 24, 2021 12:45 am » in MS Etiology and Pathogenesis

Microglia clean up toxic lipids in multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and...

0 Replies

107 Views

Last post by frodo
Fri Sep 24, 2021 12:45 am
Genome Wide Associated Study: Genes involved in lesion locations

Last post by frodo « Thu Sep 23, 2021 11:39 pm
Posted in MS Etiology and Pathogenesis

by frodo » Thu Sep 23, 2021 11:39 pm » in MS Etiology and Pathogenesis

The authors propose that some existing drugs could be repurposed to target each the genetic pathway.

An integrative study of genetic variants with...

0 Replies

73 Views

Last post by frodo
Thu Sep 23, 2021 11:39 pm
getting DRIs right

Last post by jimmylegs « Thu Sep 23, 2021 11:18 am
Posted in Diet

by jimmylegs » Thu Sep 23, 2021 11:18 am » in Diet

aha, 'my people'! ;)

Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored...

0 Replies

71 Views

Last post by jimmylegs
Thu Sep 23, 2021 11:18 am
Lenabasum

Last post by Petr75 « Tue Sep 21, 2021 5:20 am
Posted in Medical Marijuana

by Petr75 » Tue Sep 21, 2021 5:20 am » in Medical Marijuana

2021 Sep 20
Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy
Potent T cell mediated anti-inflammatory role...

0 Replies

78 Views

Last post by Petr75
Tue Sep 21, 2021 5:20 am
Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Last post by frodo « Fri Sep 17, 2021 3:01 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Fri Sep 17, 2021 3:01 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Does the venous pressure theory of multiple sclerosis pathophysiology deserve a second chance?

Summary

The theory that multiple sclerosis is...

0 Replies

126 Views

Last post by frodo
Fri Sep 17, 2021 3:01 am
central vein sign and iron in lesion as biomarkers

Last post by frodo « Wed Sep 15, 2021 11:02 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Wed Sep 15, 2021 11:02 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

The prevalence of paramagnetic rim lesions in multiple sclerosis: A systematic review and meta-analysis

Introduction

Susceptibility-based...

0 Replies

106 Views

Last post by frodo
Wed Sep 15, 2021 11:02 am
Metabolic alterations in MS

Last post by frodo « Wed Sep 15, 2021 10:53 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Sep 15, 2021 10:53 am » in MS Etiology and Pathogenesis

Carbohydrate and lipid metabolism in multiple sclerosis: Clinical implications for etiology, pathogenesis, diagnosis, prognosis, and therapy...

0 Replies

89 Views

Last post by frodo
Wed Sep 15, 2021 10:53 am
well that's just crazy

Last post by jimmylegs « Sat Sep 11, 2021 3:30 pm
Posted in General Discussion

by jimmylegs » Sat Sep 11, 2021 3:30 pm » in General Discussion

things to consider bringing to your family's attention

Reversible coma with prolonged absence of pupillary and brainstem reflexes
An unusual...

0 Replies

124 Views

Last post by jimmylegs
Sat Sep 11, 2021 3:30 pm
JUGULAR VENOUS OUTFLOW DISTURBANCE

Last post by vesta « Sat Sep 11, 2021 10:27 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by vesta » Sat Sep 11, 2021 10:27 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

JUGULAR VENOUS OUTFLOW DISTURBANCE (CEREBRAL VENOUS CONGESTION)

Sound familiar ?
As of 2018 we have a new « condition » which apparently is at the...

0 Replies

132 Views

Last post by vesta
Sat Sep 11, 2021 10:27 am
New-rology :D

Last post by jimmylegs « Fri Sep 10, 2021 3:39 am
Posted in General Discussion

by jimmylegs » Fri Sep 10, 2021 3:39 am » in General Discussion

The development of a diversity, equity, and inclusion committee in a neurology department and residency program (2021)

0 Replies

112 Views

Last post by jimmylegs
Fri Sep 10, 2021 3:39 am
Telitacicept

Last post by Petr75 « Wed Sep 01, 2021 5:23 am
Posted in Drug Pipeline

by Petr75 » Wed Sep 01, 2021 5:23 am » in Drug Pipeline

2021 Aug 31
Springer Nature, Mairangi Bay, New Zealand
Telitacicept: First Approval

Abstract

Telitacicept (Tai'ai®) is fusion protein...

0 Replies

215 Views

Last post by Petr75
Wed Sep 01, 2021 5:23 am
Review from Lassman. It includes "vascular comorbidities" influence.

Last post by frodo « Mon Aug 23, 2021 8:08 am
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by frodo » Mon Aug 23, 2021 8:08 am » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Hans Lassman is one of the heavy weights in research. He has recently written this.

8) How do vascular comorbidities influence multiple...

0 Replies

155 Views

Last post by frodo
Mon Aug 23, 2021 8:08 am
Iron in immunopattern II

Last post by frodo « Mon Aug 23, 2021 7:47 am
Posted in MS Etiology and Pathogenesis

by frodo » Mon Aug 23, 2021 7:47 am » in MS Etiology and Pathogenesis

Iron Heterogeneity in Early Active Multiple Sclerosis Lesions

Abstract

Objective

Multiple sclerosis (MS) is a heterogeneous inflammatory...

0 Replies

115 Views

Last post by frodo
Mon Aug 23, 2021 7:47 am
Two clusters of patients

Last post by frodo « Sat Aug 21, 2021 8:28 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Aug 21, 2021 8:28 am » in MS Etiology and Pathogenesis

Lesion features on MRI discriminate multiple sclerosis patients

Background: MRI provides insight into various pathological processes in multiple...

0 Replies

140 Views

Last post by frodo
Sat Aug 21, 2021 8:28 am
Dog

Last post by Petr75 « Tue Aug 10, 2021 4:04 am
Posted in General Discussion

by Petr75 » Tue Aug 10, 2021 4:04 am » in General Discussion

2021 Jul 4
Neurology, University of South Florida Morsani College of Medicine, Tampa, USA
Pet Therapy as a Nonpharmacological Treatment Option for...

0 Replies

134 Views

Last post by Petr75
Tue Aug 10, 2021 4:04 am
MRI Usage Guidelines in MS Patients

Last post by NHE « Thu Aug 05, 2021 9:35 am
Posted in General Discussion

by NHE » Thu Aug 05, 2021 9:35 am » in General Discussion

2021 MAGNIMS-CMSC-NAIMS Consensus Recommendations on the Use of MRI in Patients with Multiple Sclerosis
Lancet Neurol. 2021 Aug;20(8):653-670....

0 Replies

158 Views

Last post by NHE
Thu Aug 05, 2021 9:35 am
ms sux!

Last post by jimmylegs « Tue Aug 03, 2021 11:50 pm
Posted in Humor

by jimmylegs » Tue Aug 03, 2021 11:50 pm » in Humor

0 Replies

406 Views

Last post by jimmylegs
Tue Aug 03, 2021 11:50 pm
IgG M predicts immunosenescense

Last post by frodo « Sun Aug 01, 2021 4:19 am
Posted in MS Etiology and Pathogenesis

by frodo » Sun Aug 01, 2021 4:19 am » in MS Etiology and Pathogenesis

Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis...

0 Replies

135 Views

Last post by frodo
Sun Aug 01, 2021 4:19 am
Equine-assisted therapies

Last post by Petr75 « Sat Jul 31, 2021 7:01 am
Posted in General Discussion

by Petr75 » Sat Jul 31, 2021 7:01 am » in General Discussion

2021 Jul 23
VALFIS Research Group, Institute of Biomedicine (IBIOMED), Faculty of Physical Activity and Sports Sciences, University of León, Spain...

0 Replies

137 Views

Last post by Petr75
Sat Jul 31, 2021 7:01 am
Microglia in the NAWM

Last post by frodo « Sat Jul 31, 2021 6:03 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Jul 31, 2021 6:03 am » in MS Etiology and Pathogenesis

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis

The objective of this pilot study was to assess a 2-year change in...

0 Replies

137 Views

Last post by frodo
Sat Jul 31, 2021 6:03 am
Metabolic abnormalities in MS

Last post by frodo « Sat Jul 31, 2021 5:08 am
Posted in MS Etiology and Pathogenesis

by frodo » Sat Jul 31, 2021 5:08 am » in MS Etiology and Pathogenesis

In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing-remitting multiple sclerosis

The...

0 Replies

139 Views

Last post by frodo
Sat Jul 31, 2021 5:08 am
Ribose for MS fatigue

Last post by NHE « Mon Jul 26, 2021 3:31 am
Posted in Natural Approach

by NHE » Mon Jul 26, 2021 3:31 am » in Natural Approach

Supplemental d-ribose helps the body synthesize ATP. Have you tried d-ribose for MS fatigue? Was it helpful?

0 Replies

149 Views

Last post by NHE
Mon Jul 26, 2021 3:31 am
Hi all, well there was one small benefit from my displaced Stent.

Last post by CureIous « Sat Jul 24, 2021 4:09 pm
Posted in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

by CureIous » Sat Jul 24, 2021 4:09 pm » in Chronic Cerebrospinal Venous Insufficiency (CCSVI)

Long time
Exactly 1 month ago, I had a C4-7 disc fusion, hybrid surgery. You can clearly see my left side stovepipe , they came in from the right...

0 Replies

199 Views

Last post by CureIous
Sat Jul 24, 2021 4:09 pm
Endothelial dysfunction

Last post by Petr75 « Mon Jul 19, 2021 5:40 am
Posted in General Discussion

by Petr75 » Mon Jul 19, 2021 5:40 am » in General Discussion

2021 Jul 2
Department of Neurology and Geriatric Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
Vascular...

0 Replies

249 Views

Last post by Petr75
Mon Jul 19, 2021 5:40 am
Curcumin attenuates neuronal senescence

Last post by NHE « Sun Jul 18, 2021 7:07 am
Posted in Natural Approach

by NHE » Sun Jul 18, 2021 7:07 am » in Natural Approach

Curcumin and hesperetin attenuate D-galactose-induced brain senescence
in vitro and in vivo
Nutr Res Pract. 2020 Oct;14(5):438-452...

0 Replies

158 Views

Last post by NHE
Sun Jul 18, 2021 7:07 am
Anti-Neurofascin auto-antibody demyelination

Last post by frodo « Fri Jul 09, 2021 2:53 pm
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jul 09, 2021 2:53 pm » in MS Etiology and Pathogenesis

Anti-neurofascin autoantibody and demyelination

Highlights

• Anti-neurofascin antibodies are found in multiple sclerosis, and chronic...

0 Replies

249 Views

Last post by frodo
Fri Jul 09, 2021 2:53 pm
Shoe

Last post by Petr75 « Sat Jul 03, 2021 11:00 am
Posted in General Discussion

by Petr75 » Sat Jul 03, 2021 11:00 am » in General Discussion

2021 Jul 1
College of Health Solutions, Arizona State University, Phoenix, AZ, USA
The effect of shoe cushioning on gait and balance in females with...

0 Replies

255 Views

Last post by Petr75
Sat Jul 03, 2021 11:00 am
Copper

Last post by Petr75 « Wed Jun 30, 2021 6:50 am
Posted in General Discussion

by Petr75 » Wed Jun 30, 2021 6:50 am » in General Discussion

2021 Jul 6
Division of Neuroscience, Institute of Experimental Neurology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele...

0 Replies

281 Views

Last post by Petr75
Wed Jun 30, 2021 6:50 am
multifactorial pathogenesis not necessarily linked to inflammatory demyelination

Last post by frodo « Fri Jun 25, 2021 12:36 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jun 25, 2021 12:36 am » in MS Etiology and Pathogenesis

Microglial activation is accompanied by diffuse axonal loss in multiple sclerosis: in vivo evidence by multimodal 11C-PBR28 MR-PET and multi-shell...

0 Replies

236 Views

Last post by frodo
Fri Jun 25, 2021 12:36 am
automatic lesion pattern discrimination

Last post by frodo « Fri Jun 25, 2021 12:30 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jun 25, 2021 12:30 am » in MS Etiology and Pathogenesis

A R-Script for Generating Multiple Sclerosis Lesion Pattern Discrimination Plots

Abstract :

One significant characteristic of Multiple...

0 Replies

226 Views

Last post by frodo
Fri Jun 25, 2021 12:30 am
four groups on volume loss evolution

Last post by frodo « Fri Jun 25, 2021 12:17 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jun 25, 2021 12:17 am » in MS Etiology and Pathogenesis

Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance

Abstract

There is evidence that multiple sclerosis...

0 Replies

235 Views

Last post by frodo
Fri Jun 25, 2021 12:17 am
retinal thinning, cortical lesions, meningeal inflammation, lesions and brain atrophy are linked

Last post by frodo « Fri Jun 25, 2021 12:13 am
Posted in MS Etiology and Pathogenesis

by frodo » Fri Jun 25, 2021 12:13 am » in MS Etiology and Pathogenesis

Association of retinal atrophy with cortical lesions and leptomeningeal enhancement in multiple sclerosis on 7T MRI

Abstract
Background: Retinal...

0 Replies

235 Views

Last post by frodo
Fri Jun 25, 2021 12:13 am
subclinical activity in MS relatives

Last post by frodo « Thu Jun 24, 2021 12:34 pm
Posted in MS Etiology and Pathogenesis

by frodo » Thu Jun 24, 2021 12:34 pm » in MS Etiology and Pathogenesis

Multiple sclerosis and subclinical neuropathology in healthy individuals with familial risk

Highlights

• MRI evidence of MS pathology in...

0 Replies

241 Views

Last post by frodo
Thu Jun 24, 2021 12:34 pm
T Cells

Last post by Petr75 « Thu Jun 24, 2021 8:35 am
Posted in General Discussion

by Petr75 » Thu Jun 24, 2021 8:35 am » in General Discussion

2021 Jun 23
Department of Pharmacology, Columbia University, New York, NY, USA
T Cells: A Growing Universe of Roles in Neurodegenerative Diseases...

0 Replies

291 Views

Last post by Petr75
Thu Jun 24, 2021 8:35 am
Google

Last post by Petr75 « Sat Jun 19, 2021 4:27 am
Posted in General Discussion

by Petr75 » Sat Jun 19, 2021 4:27 am » in General Discussion

2021 Jun 17
Italian Neurological Society (SIN), First Division of Neurology, Department of Advanced Medical and Surgical Sciences, AOU-University of...

0 Replies

287 Views

Last post by Petr75
Sat Jun 19, 2021 4:27 am
Biomarkers: miR-155 and functional proteins of CD8+ T cells

Last post by frodo « Wed Jun 16, 2021 12:46 pm
Posted in MS Etiology and Pathogenesis

by frodo » Wed Jun 16, 2021 12:46 pm » in MS Etiology and Pathogenesis

miR-155 and functional proteins of CD8+ T cells as potential prognostic biomarkers for Relapsing-Remitting Multiple Sclerosis

Highlights

•...

0 Replies

268 Views

Last post by frodo
Wed Jun 16, 2021 12:46 pm
Pythagorean Self

Last post by Petr75 « Wed Jun 16, 2021 10:05 am
Posted in General Discussion

by Petr75 » Wed Jun 16, 2021 10:05 am » in General Discussion

2021 Jun 15
Postgraduate Program The Science of Stress and Health Promotion, Medical School, National Kapodistrian University of Athens, Greece...

0 Replies

291 Views

Last post by Petr75
Wed Jun 16, 2021 10:05 am
Lipoic Acid as a Potential MS Treatment Therapy

Last post by NHE « Wed Jun 16, 2021 8:14 am
Posted in Natural Approach

by NHE » Wed Jun 16, 2021 8:14 am » in Natural Approach

Lipoic Acid and Other Antioxidants as Therapies for Multiple Sclerosis
Curr Treat Options Neurol. 2019 May 6;21(6):26.

Oxidative stress (OS),...

0 Replies

266 Views

Last post by NHE
Wed Jun 16, 2021 8:14 am
R-Lipoic Acid has Better GI Tolerability

Last post by NHE « Wed Jun 16, 2021 7:16 am
Posted in Natural Approach

by NHE » Wed Jun 16, 2021 7:16 am » in Natural Approach

Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial
J Clin...

0 Replies

239 Views

Last post by NHE
Wed Jun 16, 2021 7:16 am
Rheumatoid Arthritis

Last post by Petr75 « Tue Jun 15, 2021 8:52 pm
Posted in General Discussion

by Petr75 » Tue Jun 15, 2021 8:52 pm » in General Discussion

2021 Jun 1
Barts and The London School of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, United Kingdom
Can...

0 Replies

290 Views

Last post by Petr75
Tue Jun 15, 2021 8:52 pm

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