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ADAM10

Last post by Petr75 « Mon May 10, 2021 5:46 am
Posted in General Discussion

by Petr75 » Mon May 10, 2021 5:46 am » in General Discussion

2021 May 6
Department of Pharmacology, Medical School of Southeast University, Nanjing, China
ADAM10 suppresses demyelination and reduces seizure...

0 Replies

37 Views

Last post by Petr75
Mon May 10, 2021 5:46 am
MS, HERVs and Covid 19?

Last post by vesta « Sun May 09, 2021 8:54 am
Posted in General Discussion

by vesta » Sun May 09, 2021 8:54 am » in General Discussion

Greetings:
What does this research imply for MS patients?

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association...

0 Replies

39 Views

Last post by vesta
Sun May 09, 2021 8:54 am
Cell therapy

Last post by Petr75 « Sat May 08, 2021 8:04 am
Posted in General Discussion

by Petr75 » Sat May 08, 2021 8:04 am » in General Discussion

2021 May 6
Division of Immunology, LCMN, Germans Trias i Pujol University Hospital and Research Institute, Barcelona, Spain
Paving the way towards...

0 Replies

53 Views

Last post by Petr75
Sat May 08, 2021 8:04 am
Optic pathway involvement in early MS and clinically isolated syndrome

Last post by NHE « Sat May 08, 2021 4:53 am
Posted in General Discussion

by NHE » Sat May 08, 2021 4:53 am » in General Discussion

Subclinical anterior optic pathway involvement in early multiple sclerosis and clinically isolated syndromes
Brain. 2021 Apr 12;144(3):848-862....

0 Replies

44 Views

Last post by NHE
Sat May 08, 2021 4:53 am
Lipid Receptor G2A

Last post by Petr75 « Wed May 05, 2021 4:54 am
Posted in General Discussion

by Petr75 » Wed May 05, 2021 4:54 am » in General Discussion

2021 May 3
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, Normal University, Shanghai,...

0 Replies

74 Views

Last post by Petr75
Wed May 05, 2021 4:54 am
MS as a metabolic disease

Last post by frodo « Mon May 03, 2021 2:23 am
Posted in MS Etiology and Pathogenesis

by frodo » Mon May 03, 2021 2:23 am » in MS Etiology and Pathogenesis

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than...

0 Replies

79 Views

Last post by frodo
Mon May 03, 2021 2:23 am
GW Pharmaceuticals to be Acquired by Jazz Pharmaceuticals

Last post by NHE « Wed Apr 28, 2021 2:14 am
Posted in Sativex

by NHE » Wed Apr 28, 2021 2:14 am » in Sativex

GW Pharmaceuticals Shareholders Approve Acquisition by Jazz Pharmaceuticals
April 23, 2021

LONDON and DUBLIN, April 23, 2021 (GLOBE NEWSWIRE) --...

0 Replies

76 Views

Last post by NHE
Wed Apr 28, 2021 2:14 am
automatic diagnosis of CNS diseases

Last post by frodo « Wed Apr 28, 2021 2:08 am
Posted in MS Etiology and Pathogenesis

by frodo » Wed Apr 28, 2021 2:08 am » in MS Etiology and Pathogenesis

CSF biomarkers, processed by an algorithm, can help establishing an automatic diagnosis of CNS diseases.

0 Replies

85 Views

Last post by frodo
Wed Apr 28, 2021 2:08 am
Vitamin D Resistance in Autoimmunity

Last post by Petr75 « Tue Apr 27, 2021 9:24 am
Posted in Coimbra High-Dose Vitamin D Protocol

by Petr75 » Tue Apr 27, 2021 9:24 am » in Coimbra High-Dose Vitamin D Protocol

2021 Apr 7
Praxis Dr. Beatrix Schweiger, Bensheim, Germany
Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed...

0 Replies

89 Views

Last post by Petr75
Tue Apr 27, 2021 9:24 am
Wahls: Nutritional Risks of Paleolithic Diet in Progressive MS

Last post by NHE « Sun Apr 25, 2021 1:11 am
Posted in Natural Approach

by NHE » Sun Apr 25, 2021 1:11 am » in Natural Approach

Eating Pattern and Nutritional Risks among People with Multiple Sclerosis Following a Modified Paleolithic Diet
Nutrients. 2020 Jun 20;12(6):1844....

0 Replies

123 Views

Last post by NHE
Sun Apr 25, 2021 1:11 am
Mechanism of Cuprizone Demyelination

Last post by NHE « Sat Apr 24, 2021 5:37 pm
Posted in General Discussion

by NHE » Sat Apr 24, 2021 5:37 pm » in General Discussion

Many research papers now use cuprizone induced demyelination as a model for studying MS.

Here's a few things we know about cuprizone.

Cuprizone is...

0 Replies

128 Views

Last post by NHE
Sat Apr 24, 2021 5:37 pm
Thiol/disulphide homeostasis (TDH)

Last post by Petr75 « Sat Apr 24, 2021 11:27 am
Posted in General Discussion

by Petr75 » Sat Apr 24, 2021 11:27 am » in General Discussion

2021 Apr 23
Department of Neurology, Antalya Training and Research Hospital, Antalya, Turkey
Plasma Thiol/Disulphide Homeostasis Changes In Patients...

0 Replies

111 Views

Last post by Petr75
Sat Apr 24, 2021 11:27 am
Ascorbyl-2-phosphate promotes remyelination

Last post by DIM « Fri Apr 23, 2021 11:35 am
Posted in General Discussion

by DIM » Fri Apr 23, 2021 11:35 am » in General Discussion

While As2P reduces fatigue according to other studies

0 Replies

146 Views

Last post by DIM
Fri Apr 23, 2021 11:35 am
miR-124

Last post by Petr75 « Fri Apr 23, 2021 8:52 am
Posted in General Discussion

by Petr75 » Fri Apr 23, 2021 8:52 am » in General Discussion

2021 Apr 22
The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, People's Republic of...

0 Replies

124 Views

Last post by Petr75
Fri Apr 23, 2021 8:52 am
Review: The Role of Adenosine Recptors in OPC Maturation

Last post by NHE « Fri Apr 23, 2021 8:30 am
Posted in General Discussion

by NHE » Fri Apr 23, 2021 8:30 am » in General Discussion

Oligodendrocyte precursor cell maturation: role of adenosine receptors
Neural Regen Res. 2021 Sep;16(9):1686-1692.

Oligodendrocyte-formed myelin...

0 Replies

129 Views

Last post by NHE
Fri Apr 23, 2021 8:30 am
Glatopa equivalence to Copaxone

Last post by NHE « Wed Apr 21, 2021 5:03 am
Posted in Glatopa

by NHE » Wed Apr 21, 2021 5:03 am » in Glatopa

Demonstration of equivalence of a generic glatiramer acetate (Glatopa™)
J Neurol Sci. 2015 Dec 15;359(1-2):24-34.

Glatiramer acetate (GA) has...

0 Replies

116 Views

Last post by NHE
Wed Apr 21, 2021 5:03 am
Kesimpta reduces relapse-free progression

Last post by NHE « Wed Apr 21, 2021 4:37 am
Posted in Kesimpta (Ofatumumab)

by NHE » Wed Apr 21, 2021 4:37 am » in Kesimpta (Ofatumumab)

Kesimpta® (ofatumumab) data at AAN showed reduction in disability progression independent of relapse activity in newly diagnosed patients with RMS...

0 Replies

135 Views

Last post by NHE
Wed Apr 21, 2021 4:37 am
Surface-in pathology

Last post by Petr75 « Wed Apr 21, 2021 3:42 am
Posted in MS Etiology and Pathogenesis

by Petr75 » Wed Apr 21, 2021 3:42 am » in MS Etiology and Pathogenesis

2021 Apr 20
NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London, Institute of Neurology, London, UK
Surface-in...

0 Replies

129 Views

Last post by Petr75
Wed Apr 21, 2021 3:42 am
Glatopa Prescribing Information

Last post by NHE « Wed Apr 21, 2021 12:57 am
Posted in Glatopa

by NHE » Wed Apr 21, 2021 12:57 am » in Glatopa

Glatopa Prescribing Information.

Galtopa is a generic glatiramer acetate for injection available in 20 mg/day and 40 mg/3x per week dosage regimens...

0 Replies

102 Views

Last post by NHE
Wed Apr 21, 2021 12:57 am
Ponesimod phase III trial vs. teriflunimide

Last post by NHE « Sun Apr 18, 2021 8:42 pm
Posted in Ponvory (ponesimod)

by NHE » Sun Apr 18, 2021 8:42 pm » in Ponvory (ponesimod)

Ponesimod Compared With Teriflunomide in Patients With Relapsing Multiple Sclerosis in the Active-Comparator Phase 3 OPTIMUM Study: A Randomized...

0 Replies

122 Views

Last post by NHE
Sun Apr 18, 2021 8:42 pm
Free Women's XXL cooling vest, no longer fits

Last post by savimavi « Sun Apr 18, 2021 6:52 am
Posted in Shopping

by savimavi » Sun Apr 18, 2021 6:52 am » in Shopping

I have a black women's size XXL cooling vest I no longer fit. I lost a lot of weight, and you don't feel the cooling unless it is snug. I have the...

0 Replies

212 Views

Last post by savimavi
Sun Apr 18, 2021 6:52 am
New treatment forum: Ponvory

Last post by NHE « Sun Apr 18, 2021 4:42 am
Posted in General Discussion

by NHE » Sun Apr 18, 2021 4:42 am » in General Discussion

Ponvory is an oral sphingosine 1-phosphate receptor modulator indicated for the
treatment of RRMS and active SPMS.

0 Replies

257 Views

Last post by NHE
Sun Apr 18, 2021 4:42 am
Therapeutic Potential of Ponesimod +/- Dimethyl Fumarate in EAE

Last post by NHE « Sun Apr 18, 2021 4:33 am
Posted in Ponvory (ponesimod)

by NHE » Sun Apr 18, 2021 4:33 am » in Ponvory (ponesimod)

Therapeutic Potential of Ponesimod Alone and in Combination with Dimethyl Fumarate in Experimental Models of Multiple Sclerosis
Innov Clin...

0 Replies

115 Views

Last post by NHE
Sun Apr 18, 2021 4:33 am
Ponesimod phase II trial

Last post by NHE « Sun Apr 18, 2021 3:57 am
Posted in Ponvory (ponesimod)

by NHE » Sun Apr 18, 2021 3:57 am » in Ponvory (ponesimod)

Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial
J Neurol Neurosurg Psychiatry. 2014 Nov;85(11):1198-208....

0 Replies

109 Views

Last post by NHE
Sun Apr 18, 2021 3:57 am
Ponvory prescribing information

Last post by NHE « Sun Apr 18, 2021 3:00 am
Posted in Ponvory (ponesimod)

by NHE » Sun Apr 18, 2021 3:00 am » in Ponvory (ponesimod)

Ponvory is a sphingosine 1-phosphate receptor modulator indicated for the
treatment of relapsing forms of multiple sclerosis (MS).

0 Replies

122 Views

Last post by NHE
Sun Apr 18, 2021 3:00 am
Immune Tolerance

Last post by Petr75 « Sat Apr 17, 2021 11:52 am
Posted in General Discussion

by Petr75 » Sat Apr 17, 2021 11:52 am » in General Discussion

2021 Mar 29
Department of Inflammation and Oncology, Amgen Research, Amgen Inc., South San Francisco, CA, United States
Emerging Therapeutics for...

0 Replies

123 Views

Last post by Petr75
Sat Apr 17, 2021 11:52 am
Review of neuroprotective therapies and remyelination strategies

Last post by DIM « Thu Apr 15, 2021 11:36 am
Posted in General Discussion

by DIM » Thu Apr 15, 2021 11:36 am » in General Discussion

0 Replies

167 Views

Last post by DIM
Thu Apr 15, 2021 11:36 am
what is your serum ferritin level telling you?

Last post by jimmylegs « Thu Apr 15, 2021 3:54 am
Posted in Natural Approach

by jimmylegs » Thu Apr 15, 2021 3:54 am » in Natural Approach

if you're going to work with minerals, make sure you're clear on what's really happening :)

Ferritin Is a Marker of Inflammation rather than Iron...

0 Replies

132 Views

Last post by jimmylegs
Thu Apr 15, 2021 3:54 am
Sex differences in MS

Last post by Scott1 « Tue Apr 13, 2021 5:42 pm
Posted in General Discussion

by Scott1 » Tue Apr 13, 2021 5:42 pm » in General Discussion

Finally! A really great scientist having a rant.

0 Replies

194 Views

Last post by Scott1
Tue Apr 13, 2021 5:42 pm
Rhythmic

Last post by Petr75 « Tue Apr 13, 2021 4:01 am
Posted in General Discussion

by Petr75 » Tue Apr 13, 2021 4:01 am » in General Discussion

2021 Apr 5
REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium
Rhythmic interlimb...

0 Replies

154 Views

Last post by Petr75
Tue Apr 13, 2021 4:01 am
MCT oil helps mild cognitive impairment

Last post by NHE « Sat Apr 10, 2021 3:22 pm
Posted in Natural Approach

by NHE » Sat Apr 10, 2021 3:22 pm » in Natural Approach

Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A...

0 Replies

129 Views

Last post by NHE
Sat Apr 10, 2021 3:22 pm
IndeeLift

Last post by NHE « Thu Apr 08, 2021 11:47 am
Posted in Medical Devices

by NHE » Thu Apr 08, 2021 11:47 am » in Medical Devices

The IndeeLift looks like an interesting device for folks needing help getting up off the floor.

0 Replies

257 Views

Last post by NHE
Thu Apr 08, 2021 11:47 am
The WalkAide System Product # 20-1000

Last post by sk04g « Thu Apr 08, 2021 7:46 am
Posted in Medical Devices

by sk04g » Thu Apr 08, 2021 7:46 am » in Medical Devices

Selling a WalkAide System for $5500 or best offer. Unit was tried on and it didn't work out. Message me if you have any questions! :)

0 Replies

133 Views

Last post by sk04g
Thu Apr 08, 2021 7:46 am
BDNF precursor in the immune system is a novel target for treating MS

Last post by NHE « Thu Apr 08, 2021 3:18 am
Posted in General Discussion

by NHE » Thu Apr 08, 2021 3:18 am » in General Discussion

Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis
Theranostics. 2021 Jan...

0 Replies

168 Views

Last post by NHE
Thu Apr 08, 2021 3:18 am
Adolescent infection increases MS risk

Last post by NHE « Thu Apr 08, 2021 3:01 am
Posted in MS Etiology and Pathogenesis

by NHE » Thu Apr 08, 2021 3:01 am » in MS Etiology and Pathogenesis

Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis
Brain. 2021 Mar 9;awab100.

The involvement of...

0 Replies

147 Views

Last post by NHE
Thu Apr 08, 2021 3:01 am
Mast cells

Last post by Petr75 « Tue Apr 06, 2021 3:58 am
Posted in General Discussion

by Petr75 » Tue Apr 06, 2021 3:58 am » in General Discussion

2021 Nov
Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China
Neuroimmune...

0 Replies

184 Views

Last post by Petr75
Tue Apr 06, 2021 3:58 am
OCT shows reduced retinal layer thickness is associated with disability progression

Last post by NHE « Thu Apr 01, 2021 5:20 pm
Posted in General Discussion

by NHE » Thu Apr 01, 2021 5:20 pm » in General Discussion

Association of Spectral-Domain OCT With Long-term Disability Worsening in Multiple Sclerosis
Neurology. 2021 Mar 2;10.1212

Objective: To evaluate...

0 Replies

185 Views

Last post by NHE
Thu Apr 01, 2021 5:20 pm
Acetyl L-Carnitine Arginate promotes nerve growth factor...

Last post by DIM « Thu Apr 01, 2021 4:01 am
Posted in General Discussion

by DIM » Thu Apr 01, 2021 4:01 am » in General Discussion

...3,5 fold more than Acetyl L-Carnitine:

(

0 Replies

195 Views

Last post by DIM
Thu Apr 01, 2021 4:01 am
Echoes

Last post by NHE « Tue Mar 30, 2021 5:57 am
Posted in Daily Life

by NHE » Tue Mar 30, 2021 5:57 am » in Daily Life

Overhead the albatross hangs motionless upon the air
And deep beneath the rolling waves in labyrinths of coral caves
The echo of a distant time comes...

0 Replies

310 Views

Last post by NHE
Tue Mar 30, 2021 5:57 am
Behçet's Disease Is Associated with MS and Rheumatoid Arthritis

Last post by Petr75 « Wed Mar 24, 2021 10:39 am
Posted in General Discussion

by Petr75 » Wed Mar 24, 2021 10:39 am » in General Discussion

2021 Mar 23
Department of Biomedicine and Health Science, Graduate School, The Catholic University of Korea, Seoul, Republic of Korea
Behçet's...

0 Replies

212 Views

Last post by Petr75
Wed Mar 24, 2021 10:39 am
MnTBAP

Last post by Petr75 « Wed Mar 24, 2021 8:32 am
Posted in General Discussion

by Petr75 » Wed Mar 24, 2021 8:32 am » in General Discussion

2021 Mar 8
Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical School, Dallas, TX, USA
The antioxidant MnTBAP does...

0 Replies

194 Views

Last post by Petr75
Wed Mar 24, 2021 8:32 am
Acyclovir/Valacyclovir long term use

Last post by DIM « Mon Mar 22, 2021 6:41 am
Posted in General Medications

by DIM » Mon Mar 22, 2021 6:41 am » in General Medications

For those that take one of the above antivirals for their MS could you post please:

-for how long you take it
-what, if any, side effects you...

0 Replies

287 Views

Last post by DIM
Mon Mar 22, 2021 6:41 am
Autonomic Dysfunction in MS: Exercise Implications

Last post by jimmylegs « Fri Mar 19, 2021 1:22 pm
Posted in Exercise and Physical Therapy

by jimmylegs » Fri Mar 19, 2021 1:22 pm » in Exercise and Physical Therapy

Autonomic Dysfunction in Multiple Sclerosis: Implications for Exercise (2014)

... Conclusion
Compounding evidence now indicates that regular...

0 Replies

157 Views

Last post by jimmylegs
Fri Mar 19, 2021 1:22 pm
Dopamine

Last post by Petr75 « Thu Mar 18, 2021 4:06 am
Posted in General Discussion

by Petr75 » Thu Mar 18, 2021 4:06 am » in General Discussion

2021
Federal Center of Brain Research and Neurotechnology, Moscow, Russia
The prospect of dopaminergic therapy in multiple sclerosis

Abstract...

0 Replies

209 Views

Last post by Petr75
Thu Mar 18, 2021 4:06 am
Ocrevus vs. Kesimpta

Last post by NHE « Wed Mar 17, 2021 8:16 pm
Posted in Ocrevus (Ocrelizumab)

by NHE » Wed Mar 17, 2021 8:16 pm » in Ocrevus (Ocrelizumab)

Ocrevus and Kesimpta are two different anti-CD20 antibodies which induce B-cell depletion. Dr. Brandon Beaber presents an interesting comparison of...

0 Replies

202 Views

Last post by NHE
Wed Mar 17, 2021 8:16 pm
Blood Trace Element Status in pwMS

Last post by jimmylegs « Wed Mar 17, 2021 9:01 am
Posted in Natural Approach

by jimmylegs » Wed Mar 17, 2021 9:01 am » in Natural Approach

Blood Trace Element Status in Multiple Sclerosis: a Systematic Review and Meta-analysis (2021)

This meta-analysis revealed that the circulating...

0 Replies

178 Views

Last post by jimmylegs
Wed Mar 17, 2021 9:01 am
Telmisartan

Last post by Petr75 « Wed Mar 17, 2021 4:08 am
Posted in General Discussion

by Petr75 » Wed Mar 17, 2021 4:08 am » in General Discussion

2021 Mar 11
Center of Excellence, Arab Academy for Science and Technology and Maritime Transport, Alexandria, Egypt
Neuroprotective Effects of...

0 Replies

193 Views

Last post by Petr75
Wed Mar 17, 2021 4:08 am
QSM-MRI can show brain inflammation.

Last post by frodo « Tue Mar 16, 2021 10:55 am
Posted in MS Etiology and Pathogenesis

by frodo » Tue Mar 16, 2021 10:55 am » in MS Etiology and Pathogenesis

QSM-MRI can show brain inflammation. Currently there is none.

QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions...

0 Replies

163 Views

Last post by frodo
Tue Mar 16, 2021 10:55 am
the funny snow man

Last post by zen2010 « Sun Mar 14, 2021 11:48 am
Posted in Humor

by zen2010 » Sun Mar 14, 2021 11:48 am » in Humor

lol

0 Replies

393 Views

Last post by zen2010
Sun Mar 14, 2021 11:48 am
Molecular hydrogen

Last post by Petr75 « Fri Mar 12, 2021 9:55 pm
Posted in General Discussion

by Petr75 » Fri Mar 12, 2021 9:55 pm » in General Discussion

2016 May 15
Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of the Ministry of Education, Second Military Medical University,...

0 Replies

221 Views

Last post by Petr75
Fri Mar 12, 2021 9:55 pm

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