Search found 1519 matches

by frodo
Thu Jun 25, 2020 1:26 am
Forum: MS Etiology and Pathogenesis
Topic: The lancet. Open call for using NFL in diagnosis and monitoring
Replies: 1
Views: 145

The lancet. Open call for using NFL in diagnosis and monitoring

Neurofilament light in blood. What more is needed for clinical implementation? https://www.thelancet.com/pdfs/journals/ebiom/PIIS2352-3964(20)30201-2.pdf Cerebrospinalfluid (CSF) neurofilament light (NfL) is the best established fluid biomarker for neuroaxonal injury, irrespective of the underlying...
by frodo
Tue Jun 23, 2020 8:57 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Thesis: The endothelial angiopoietin-Tie signaling pathway
Replies: 0
Views: 142

Thesis: The endothelial angiopoietin-Tie signaling pathway

A new link between MS and the vascular system and angiogenesis https://helda.helsinki.fi/handle/10138/316187 Overall, this thesis provides insight into the function of Tie1 and Ang2. Our studies reveal previously unknown roles of Tie1 in lymphatic vessel development, postnatal sprouting angiogenesis...
by frodo
Tue Jun 23, 2020 8:52 am
Forum: Drug Pipeline
Topic: Next DMTs to come
Replies: 0
Views: 130

Next DMTs to come

Ozanimod, laquinimod, BTK inhibitors (fenebrutinib, ibrutinib, and evobrutinib), Ibudilast, Lipoic acid and (maybe) Biotin. Source: https://www.mdpi.com/1422-0067/21/12/4312/htm Emerging Treatments In addition to the available medication options for treating MS, new drugs that act on different biolo...
by frodo
Tue Jun 23, 2020 8:46 am
Forum: MS Etiology and Pathogenesis
Topic: Biotin treatment can turn PPMS into relapsing
Replies: 0
Views: 159

Biotin treatment can turn PPMS into relapsing

There are contradicting reports on this topic. See for instance https://www.thisisms.com/forum/viewtopic.php?f=59&t=31464&p=259617&hilit=biotin#p259617 Relapses During High-Dose Biotin Treatment in Progressive Multiple Sclerosis: a Case-Crossover and Propensity Score-Adjusted Prospective Cohort http...
by frodo
Tue Jun 23, 2020 8:44 am
Forum: MS Etiology and Pathogenesis
Topic: Automatic segmentation of different lesion types
Replies: 0
Views: 87

Automatic segmentation of different lesion types

Identification of Multiple Sclerosis lesion subtypes and their quantitative assessments with EDSS using neuroimaging https://link.springer.com/content/pdf/10.1007/s13721-020-00245-8.pdf Abstract It would be helpful to have an automatic segmentation method to provide an acceptable performance of Mag...
by frodo
Tue Jun 23, 2020 8:34 am
Forum: MS Etiology and Pathogenesis
Topic: STIR Imaging of Intracranial Disease
Replies: 0
Views: 88

STIR Imaging of Intracranial Disease

Postcontrast STIR imaging offers additional information, not obtained with other sequences: Postcontrast STIR Imaging of Intracranial Disease Processes – a Pilot Study https://www.bib.irb.hr/1066749 Objectives : To asses postcontrast Short Tau Inversion Recovery (STIR) MR images for potential new in...
by frodo
Fri Jun 19, 2020 1:42 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Angiopoietin-2
Replies: 2
Views: 2874

Re: Angiopoietin-2

Angiopoietin-2 (Ang2), a ligand of the endothelial Tie2 tyrosine kinase, is involved in vascular inflammation and leakage in critically ill patients. However, the role of Ang2 in demyelinating central nervous system (CNS) autoimmune diseases is unknown. Here, we report that Ang2 is critically invol...
by frodo
Fri Jun 19, 2020 1:34 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Endothelin-1 activates microglia
Replies: 2
Views: 298

Re: Endothelin-1 activates microglia

ThisIsMA wrote:
Tue Jun 16, 2020 9:33 am
Hi Frodo, This seems like an excellent study that Joan should know about if she hasn't already seen it. I don't see a link to the study though. Can you post one? Thanks!
Sorry. Here you have it.

https://faseb.onlinelibrary.wiley.com/d ... 4.s1.02351
by frodo
Fri Jun 19, 2020 1:21 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: Vascular malformations masquerading as demyelinating disease. May be the explanation?
Replies: 2
Views: 1985

Re: Vascular malformations masquerading as demyelinating disease. May be the explanation?

Wow, I'd sure like to read that study, but its behind a paywall. In my case I can read it without any warning. I suppose that it is possible to reproduce an excerpt acknowleging the authorship. It is a review of three cases in which patients with vascular problems present demyelination and were dia...
by frodo
Fri Jun 19, 2020 1:17 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular problems in the MS eyes
Replies: 4
Views: 283

Re: vascular problems in the MS eyes

ThisIsMA wrote:
Tue Jun 16, 2020 8:55 am
Interesting study! 5 out of 7 subjects with MS had this, that's a high percentage (71.4 percent). Even though a very small sample size. Hopefully they'll follow up with a larger study. Thanks for posting this study.
Yes. It is something that could yield new information
by frodo
Tue Jun 16, 2020 2:59 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular problems in the MS eyes
Replies: 4
Views: 283

Re: vascular problems in the MS eyes

Novel microscopic foveal pit pathology in multiple sclerosis revealed with adaptive optics ophthalmoscopy https://iovs.arvojournals.org/article.aspx?articleid=2769442 Conclusions : Previously unreported microscopic features, not detectable with clinical examination, were observed in the foveal pit o...
by frodo
Tue Jun 16, 2020 2:56 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular problems in the MS eyes
Replies: 4
Views: 283

Retinal vascular changes in Multiple Sclerosis

Characterization of Retinal vascular changes in Multiple Sclerosis using Adaptive Optics and OCTA https://iovs.arvojournals.org/article.aspx?articleid=2768856 Conclusions AO-SLO (Adaptive optics scanning laser ophthalmoscopy) demonstrates focal retinal vessel changes in living human MS eyes without...
by frodo
Tue Jun 16, 2020 2:53 am
Forum: Chronic Cerebrospinal Venous Insufficiency (CCSVI)
Topic: vascular problems in the MS eyes
Replies: 4
Views: 283

vascular problems in the MS eyes

Identifying Microvascular Differences in Multiple Sclerosis via Optical Coherence Tomography Angiography (OCT-A) https://iovs.arvojournals.org/article.aspx?articleid=2768711 Conclusions : Curated OCT-A and macular vessel density data suggests microvascular differences in MS patient groups compared t...
by frodo
Tue Jun 16, 2020 2:33 am
Forum: MS Etiology and Pathogenesis
Topic: prognosis based in a blood test
Replies: 0
Views: 274

prognosis based in a blood test

Clues to prognosis in multiple sclerosis found in the blood https://www.nature.com/articles/s41582-020-0376-9 Neurofilament light (NfL) and microRNAs (miRNAs) can help to predict the course that multiple sclerosis (MS) will take for individuals, according to two new studies published in Neurology a...
by frodo
Tue Jun 16, 2020 2:26 am
Forum: MS Etiology and Pathogenesis
Topic: The division of MS in "types" was made up just to approve interferons
Replies: 1
Views: 156

new "type" under research

New "type" under research. They are trying to achieve a standard definition for agressive MS. Maybe this will be more interesting than the previous "types". The paper has two parts: https://journals.sagepub.com/doi/full/10.1177/1352458520925369 https://journals.sagepub.com/doi/full/10.1177/135245852...

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