Search found 1780 matches

by frodo
Tue Sep 12, 2023 3:59 am
Forum: MS Etiology and Pathogenesis
Topic: Learning MS pathogenesis from anti-CD20 therapy
Replies: 0
Views: 9142

Learning MS pathogenesis from anti-CD20 therapy

Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy https://www.pnas.org/doi/full/10.1073/pnas.2221544120 Summary: 1) By analyzing blood immune profiles of patients receiving disease-modifying immune therapies, we can learn how therapy impacts the immune system (“mode of action” t...
by frodo
Wed Sep 06, 2023 11:40 am
Forum: General Discussion
Topic: EBV Autologous T-Cell Therapy: Long Term Results
Replies: 1
Views: 8803

Re: EBV Autologous T-Cell Therapy: Long Term Results

Updated March 2023: I think this refers to the same treatment Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sc...
by frodo
Wed Sep 06, 2023 11:16 am
Forum: MS Etiology and Pathogenesis
Topic: Targeting EBV as a therapy: Allogeneic EBV T-cell therapy
Replies: 0
Views: 10769

Targeting EBV as a therapy: Allogeneic EBV T-cell therapy

Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sclerosis has provided an impetus to develop immune-based thera...
by frodo
Wed Sep 06, 2023 10:33 am
Forum: MS Etiology and Pathogenesis
Topic: Glialcam, ANO2 and α-β crystalin are to blame. What is next?
Replies: 0
Views: 4711

Glialcam, ANO2 and α-β crystalin are to blame. What is next?

Roadmap for understanding mechanisms on how Epstein–Barr virus triggers multiple sclerosis and for translating these discoveries in clinical trials https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1438 Abstract Here, we offer a roadmap for what might be studied next in understanding how EBV tr...
by frodo
Thu Aug 31, 2023 3:40 am
Forum: MS Etiology and Pathogenesis
Topic: Ibudilast works for PPMS but not for SPMS
Replies: 0
Views: 8139

Ibudilast works for PPMS but not for SPMS

Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes https://n.neurology.org/content/early/2023/07/16/WNL.0000000000207551.abstract Discussion : Ibudilast treatment decreased GCIPL atrophy in PMS, driven by the PPMS cohort, with no effect seen in SPMS. Modulated atroph...
by frodo
Tue Aug 22, 2023 12:08 am
Forum: MS Etiology and Pathogenesis
Topic: Migraine can predispose to MS
Replies: 0
Views: 4762

Migraine can predispose to MS

Advanced brain MRI may help understand the link between migraine and multiple sclerosis https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-023-01645-7 Conclusion In summary, there is clinical evidence for an association of migraine and MS. Both clinical studies as well as...
by frodo
Tue Aug 15, 2023 11:58 pm
Forum: MS Etiology and Pathogenesis
Topic: Smouldering Lesion in MS: Pathobiochemical Mechanisms
Replies: 0
Views: 5787

Smouldering Lesion in MS: Pathobiochemical Mechanisms

Smouldering Lesion in MS: Microglia, Lymphocytes and Pathobiochemical Mechanisms https://www.mdpi.com/1422-0067/24/16/12631 Abstract Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Immune cell inf...
by frodo
Tue Aug 15, 2023 11:06 pm
Forum: MS Etiology and Pathogenesis
Topic: Auto antibodies in patients with multiple sclerosis
Replies: 0
Views: 10962

Auto antibodies in patients with multiple sclerosis

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis https://academic.oup.com/braincomms/article/5/2/fcad109/7103320 Abstract Multiple sclerosis is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targ...
by frodo
Sat Aug 05, 2023 2:20 pm
Forum: MS Etiology and Pathogenesis
Topic: Alterations in peripheral blood B cells
Replies: 0
Views: 10583

Alterations in peripheral blood B cells

Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02859-x Abstract Background Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenera...
by frodo
Mon Jun 26, 2023 6:38 am
Forum: MS Etiology and Pathogenesis
Topic: myelin phagocytes in MS derive entirely from infiltrating monocytes
Replies: 0
Views: 6088

myelin phagocytes in MS derive entirely from infiltrating monocytes

https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlad046/7204747?login=false Abstract The study was designed to examine microglia morphology in early and late forms of multiple sclerosis (MS). Archival paraffin embedded tissue samples from 25 cases were examined immunohistochemically. ...
by frodo
Mon Jun 26, 2023 6:35 am
Forum: MS Etiology and Pathogenesis
Topic: prognostic cerebrospinal fluid markers
Replies: 0
Views: 6100

prognostic cerebrospinal fluid markers

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287463 Background Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reve...
by frodo
Mon Jun 26, 2023 6:32 am
Forum: MS Etiology and Pathogenesis
Topic: Pathological ultrastructural alterations in NAWM
Replies: 0
Views: 3543

Pathological ultrastructural alterations in NAWM

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01598-7 Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of ...
by frodo
Wed Jun 07, 2023 6:45 am
Forum: MS Etiology and Pathogenesis
Topic: rapid diagnosis of multiple sclerosis by Raman spectroscopy
Replies: 0
Views: 4390

rapid diagnosis of multiple sclerosis by Raman spectroscopy

Carotenoids contribution in rapid diagnosis of multiple sclerosis by Raman spectroscopy https://www.sciencedirect.com/science/article/abs/pii/S0304416523000934 Highlights • Rapid and novel screening test of blood fraction reveals the biochemical fingerprint of multiple sclerosis (MS). • Raman spect...
by frodo
Wed Jun 07, 2023 6:42 am
Forum: MS Etiology and Pathogenesis
Topic: diagnosis by proteins in tears
Replies: 0
Views: 4922

diagnosis by proteins in tears

Experimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis https://www.mdpi.com/1424-8220/23/11/5251 Conclusions According to this study, MS patients have altered tear proteomes. The tear proteome may be a good indicator of MS-related disorders and CNS inflammati...
by frodo
Wed Jun 07, 2023 6:34 am
Forum: MS Etiology and Pathogenesis
Topic: metabolic alterations in the normal‑appearing grey and white matter
Replies: 0
Views: 4174

metabolic alterations in the normal‑appearing grey and white matter

metabolic alterations in the normal‑appearing grey and white matter of patients with clinically isolated syndrome https://www.spandidos-publications.com/10.3892/etm.2023.12048 Abstract Proton magnetic resonance spectroscopy (1H‑MRS) is an advanced method of examining metabolic profiles. The present...

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