Search found 1780 matches
- Tue Sep 12, 2023 3:59 am
- Forum: MS Etiology and Pathogenesis
- Topic: Learning MS pathogenesis from anti-CD20 therapy
- Replies: 0
- Views: 9142
Learning MS pathogenesis from anti-CD20 therapy
Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy https://www.pnas.org/doi/full/10.1073/pnas.2221544120 Summary: 1) By analyzing blood immune profiles of patients receiving disease-modifying immune therapies, we can learn how therapy impacts the immune system (“mode of action” t...
- Wed Sep 06, 2023 11:40 am
- Forum: General Discussion
- Topic: EBV Autologous T-Cell Therapy: Long Term Results
- Replies: 1
- Views: 8803
Re: EBV Autologous T-Cell Therapy: Long Term Results
Updated March 2023: I think this refers to the same treatment Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sc...
- Wed Sep 06, 2023 11:16 am
- Forum: MS Etiology and Pathogenesis
- Topic: Targeting EBV as a therapy: Allogeneic EBV T-cell therapy
- Replies: 0
- Views: 10769
Targeting EBV as a therapy: Allogeneic EBV T-cell therapy
Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1444 Abstract Emergence of a definitive link between Epstein–Barr virus (EBV) and multiple sclerosis has provided an impetus to develop immune-based thera...
- Wed Sep 06, 2023 10:33 am
- Forum: MS Etiology and Pathogenesis
- Topic: Glialcam, ANO2 and α-β crystalin are to blame. What is next?
- Replies: 0
- Views: 4711
Glialcam, ANO2 and α-β crystalin are to blame. What is next?
Roadmap for understanding mechanisms on how Epstein–Barr virus triggers multiple sclerosis and for translating these discoveries in clinical trials https://onlinelibrary.wiley.com/doi/full/10.1002/cti2.1438 Abstract Here, we offer a roadmap for what might be studied next in understanding how EBV tr...
- Thu Aug 31, 2023 3:40 am
- Forum: MS Etiology and Pathogenesis
- Topic: Ibudilast works for PPMS but not for SPMS
- Replies: 0
- Views: 8139
Ibudilast works for PPMS but not for SPMS
Effects of Ibudilast on Retinal Atrophy in Progressive Multiple Sclerosis Subtypes https://n.neurology.org/content/early/2023/07/16/WNL.0000000000207551.abstract Discussion : Ibudilast treatment decreased GCIPL atrophy in PMS, driven by the PPMS cohort, with no effect seen in SPMS. Modulated atroph...
- Tue Aug 22, 2023 12:08 am
- Forum: MS Etiology and Pathogenesis
- Topic: Migraine can predispose to MS
- Replies: 0
- Views: 4762
Migraine can predispose to MS
Advanced brain MRI may help understand the link between migraine and multiple sclerosis https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-023-01645-7 Conclusion In summary, there is clinical evidence for an association of migraine and MS. Both clinical studies as well as...
- Tue Aug 15, 2023 11:58 pm
- Forum: MS Etiology and Pathogenesis
- Topic: Smouldering Lesion in MS: Pathobiochemical Mechanisms
- Replies: 0
- Views: 5787
Smouldering Lesion in MS: Pathobiochemical Mechanisms
Smouldering Lesion in MS: Microglia, Lymphocytes and Pathobiochemical Mechanisms https://www.mdpi.com/1422-0067/24/16/12631 Abstract Multiple sclerosis (MS) is an immune-mediated, chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS). Immune cell inf...
- Tue Aug 15, 2023 11:06 pm
- Forum: MS Etiology and Pathogenesis
- Topic: Auto antibodies in patients with multiple sclerosis
- Replies: 0
- Views: 10962
Auto antibodies in patients with multiple sclerosis
Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis https://academic.oup.com/braincomms/article/5/2/fcad109/7103320 Abstract Multiple sclerosis is a tissue-specific autoimmune disease of the central nervous system in which the antigen(s) remains elusive. Antibodies targ...
- Sat Aug 05, 2023 2:20 pm
- Forum: MS Etiology and Pathogenesis
- Topic: Alterations in peripheral blood B cells
- Replies: 0
- Views: 10583
Alterations in peripheral blood B cells
Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02859-x Abstract Background Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenera...
- Mon Jun 26, 2023 6:38 am
- Forum: MS Etiology and Pathogenesis
- Topic: myelin phagocytes in MS derive entirely from infiltrating monocytes
- Replies: 0
- Views: 6088
myelin phagocytes in MS derive entirely from infiltrating monocytes
https://academic.oup.com/jnen/advance-article/doi/10.1093/jnen/nlad046/7204747?login=false Abstract The study was designed to examine microglia morphology in early and late forms of multiple sclerosis (MS). Archival paraffin embedded tissue samples from 25 cases were examined immunohistochemically. ...
- Mon Jun 26, 2023 6:35 am
- Forum: MS Etiology and Pathogenesis
- Topic: prognostic cerebrospinal fluid markers
- Replies: 0
- Views: 6100
prognostic cerebrospinal fluid markers
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287463 Background Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reve...
- Mon Jun 26, 2023 6:32 am
- Forum: MS Etiology and Pathogenesis
- Topic: Pathological ultrastructural alterations in NAWM
- Replies: 0
- Views: 3543
Pathological ultrastructural alterations in NAWM
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-023-01598-7 Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of ...
- Wed Jun 07, 2023 6:45 am
- Forum: MS Etiology and Pathogenesis
- Topic: rapid diagnosis of multiple sclerosis by Raman spectroscopy
- Replies: 0
- Views: 4390
rapid diagnosis of multiple sclerosis by Raman spectroscopy
Carotenoids contribution in rapid diagnosis of multiple sclerosis by Raman spectroscopy https://www.sciencedirect.com/science/article/abs/pii/S0304416523000934 Highlights • Rapid and novel screening test of blood fraction reveals the biochemical fingerprint of multiple sclerosis (MS). • Raman spect...
- Wed Jun 07, 2023 6:42 am
- Forum: MS Etiology and Pathogenesis
- Topic: diagnosis by proteins in tears
- Replies: 0
- Views: 4922
diagnosis by proteins in tears
Experimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis https://www.mdpi.com/1424-8220/23/11/5251 Conclusions According to this study, MS patients have altered tear proteomes. The tear proteome may be a good indicator of MS-related disorders and CNS inflammati...
- Wed Jun 07, 2023 6:34 am
- Forum: MS Etiology and Pathogenesis
- Topic: metabolic alterations in the normal‑appearing grey and white matter
- Replies: 0
- Views: 4174
metabolic alterations in the normal‑appearing grey and white matter
metabolic alterations in the normal‑appearing grey and white matter of patients with clinically isolated syndrome https://www.spandidos-publications.com/10.3892/etm.2023.12048 Abstract Proton magnetic resonance spectroscopy (1H‑MRS) is an advanced method of examining metabolic profiles. The present...