A board to discuss future MS therapies in early stage (Phase I or II) trials.
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Coronavirus (COVID-19): What You Need To Know
Replies: 142
by
jimmylegs » Sun Mar 15, 2020 4:10 am » in
General Discussion
First post
What You Need To Know About Coronavirus (COVID-19)
What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...
Last post
See also:
A Review of SARS-CoV-2 and the Ongoing Clinical Trials.
Tu YF, Chien CS, Yarmishyn AA, Lin YY, Luo YH, Lin YT, Lai WY, Yang DM, Chou SJ,...
- 142 Replies
- 14344 Views
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Last post by vesta
Wed Jul 08, 2020 10:52 am
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KineMed
Replies: 1
by
bromley » Mon Apr 03, 2006 9:32 am
First post
It might as well be written in Chinese, but it looks as if another company is looking at possbible therapies for MS and other neurological diseases -...
Last post
Based on this press release, I'll add 13-cis-retinoic acid to the pre-clinical stage. The more the merrier.
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Last post by dignan
Mon Apr 03, 2006 11:09 am
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Completed Phase II trial of oral IFN-alpha
Replies: 2
by
dignan » Sat Apr 01, 2006 4:45 pm
First post
Interesting that this talks about a completed phase II trial of an oral treatment. I hope if they do another trial it will be phase III.
Ingested...
Last post
Good point Bromley, it isn't on the list. Well, it is now. Alferon, which was/is on the list is also interferon alpha and I was thinking that it was...
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- 2412 Views
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Last post by dignan
Sun Apr 02, 2006 9:42 am
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Zenapax (Daclizumab)
Replies: 6
by
Dunmann » Tue Mar 28, 2006 11:36 am
First post
Hopes raised for effectiveness of Multiple Sclerosis drug
A national research team led by the University of Cincinnati's Bibiana Bielekova, MD,...
Last post
I think it's worth noting that even though these natural killer cells apparently increase during pregnancy, which would also put into play more...
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Last post by Shayk
Sun Apr 02, 2006 8:43 am
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Neurovax news
by
bromley » Wed Mar 29, 2006 7:03 am
The additions to the board are impressive e.g Antel and Bourdette. These T-Reg cells keep cropping up and were mentioned in the Zenapax (Dacluzimab)...
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- 1670 Views
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Last post by bromley
Wed Mar 29, 2006 7:03 am
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Tovaxin
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bromley » Tue Mar 28, 2006 1:27 pm
The company behind Tovaxin are presenting data at a conference in early May
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Last post by bromley
Tue Mar 28, 2006 1:27 pm
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Vaccine
Replies: 3
by
bromley » Sun Mar 19, 2006 11:27 am
First post
Dignan,
A T cell vaccine (like Tovaxin) being trialled in Israel. Lokks like reults might be out in a few months.
Ian
Last post
It's funny that you would say that Ian. As I have said before, patience is not one of my virtues. I was just telling my boyfriend yesterday that I...
- 3 Replies
- 2338 Views
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Last post by scoobyjude
Mon Mar 27, 2006 5:11 pm
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NNZ-2566
by
bromley » Sat Mar 25, 2006 7:22 am
This is one of the drugs in the pipeline at Neuren. It is a neuro-protective drug and pre-clinical results look promising. I think it has just...
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- 1871 Views
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Last post by bromley
Sat Mar 25, 2006 7:22 am
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FTY720
Replies: 4
by
bromley » Thu Mar 16, 2006 9:29 am
First post
FTY720 is seen by some as being the 'gold standard' for MS treatment in the future. Unfortunately, approval unlikely until 2010.
In recognition of...
Last post
Is there any data on reducing progression to disability? I think everyone is coming to accept that reduction of lesion load and relapse rate do not...
- 4 Replies
- 2751 Views
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Last post by billf
Thu Mar 23, 2006 10:32 am
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Laquinimod
by
bromley » Wed Mar 22, 2006 8:39 am
Research article on Laquinimod. Good at reducing lesions but no impact on disability (isn't this what we want?)
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- 1784 Views
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Last post by bromley
Wed Mar 22, 2006 8:39 am
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Oral Copaxone
Replies: 1
by
viper498 » Tue Mar 21, 2006 6:21 am
First post
Darn it... Just get me a pill! I hate these d*mn Rebif injections!!!!!!
Last post
Nice to hear that they knew about the ineffectiveness of the drug, yet still got people to participate in the trials!
It was nice to read however,...
- 1 Replies
- 2205 Views
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Last post by Dunmann
Tue Mar 21, 2006 7:26 am
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Rituximab
Replies: 4
by
bromley » Mon Mar 20, 2006 9:08 am
First post
Rituximab (Rituxin) is currently being trialled for PP, SP, RR MS and targets the B cells.
Rituximab was recently approved (by the FDA) for use in...
Last post
Ian,
I am very interested to hear on this site about new discoveries in the EBV area.
As we are talking about votes, concerning any future...
- 4 Replies
- 2602 Views
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Last post by Degerlache
Tue Mar 21, 2006 7:05 am
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MBP8298 For RRMS
Replies: 1
by
Dunmann » Mon Mar 13, 2006 8:54 am
First post
BioMS Plans Relapsing-Remitting Multiple Sclerosis Trial
- MBP8298 to be tested in a second major MS patient population -
EDMONTON, Alberta,...
Last post
Dunmann,
Good spot.
findings will be presented at the 58th Annual Meeting of the American Academy of Neurology on April 4, 2006 in San Diego, CA....
- 1 Replies
- 1920 Views
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Last post by bromley
Wed Mar 15, 2006 12:57 pm
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exosomes
Replies: 1
by
bromley » Tue Mar 14, 2006 1:37 pm
First post
Dignan,
Probably shouldn't go on the list as its only a possibility that it might be beneficial for MS.
Last post
Agreed. I think we should wait at least until they do some preliminary research specific to MS before it hits the list. Having said that, I like the...
- 1 Replies
- 1615 Views
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Last post by dignan
Wed Mar 15, 2006 8:18 am
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The pharma industry
Replies: 12
by
rasnet6 » Thu Mar 09, 2006 1:17 am
First post
I read postings on this forum on a regular basis and quite often it amases me. We all have an awful disease and it is a rough ride. But i think we...
Last post
You are right about that. I am also relatively young (31) and I have a lot of hope for the future. Maybe the reason that older people with MS or even...
- 12 Replies
- 3499 Views
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Last post by scoobyjude
Tue Mar 14, 2006 9:18 pm
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Overview of drugs
by
bromley » Tue Mar 14, 2006 1:46 pm
Nothing new but a summary of what's available / in the pipeline.
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- 2099 Views
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Last post by bromley
Tue Mar 14, 2006 1:46 pm
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Gemacbio
by
bromley » Mon Mar 13, 2006 2:57 am
I think the following is old news. Unfortunately, no details about how effective the treatment is - but I like the three pronged approach. It's very...
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- 1581 Views
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Last post by bromley
Mon Mar 13, 2006 2:57 am
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Tovaxin Update/Trial
Replies: 3
by
Dunmann » Thu Mar 09, 2006 6:07 am
First post
This from BBC news.
MS vaccine testing to start in US
Researchers are working towards having an MS vaccine
A US company is set to begin a trial...
Last post
You're right about that. It had occured to me too but I think I just chose to block out the logical problems because I am so hopeful about it. If it...
- 3 Replies
- 2354 Views
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Last post by scoobyjude
Fri Mar 10, 2006 12:57 pm
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Generic interferons
by
dignan » Wed Mar 08, 2006 4:13 pm
Not that anybody is excited about interferons, but if they must be taken at least they might be about to get cheaper...
Ratiopharm: competes with...
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- 1907 Views
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Last post by dignan
Wed Mar 08, 2006 4:13 pm
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Neurocrine APL
Replies: 1
by
bromley » Wed Mar 08, 2006 5:47 am
First post
Dignan,
If this was on the list you need to erase it.
Ian
Last post
Damnit, you're right of course.
- 1 Replies
- 1728 Views
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Last post by dignan
Wed Mar 08, 2006 7:47 am
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MBP8298 update
Replies: 1
by
dignan » Tue Mar 07, 2006 8:05 am
First post
This sounds promising, although they don't provide much information here...
BioMS Medical's MBP8298 Shows Five-year Delay of Disease Progression...
Last post
Thanks Dignan and Dunmann,
I think the company has been working on this drug for 20 years.
I'm not clear what 'delayed disease progression' means -...
- 1 Replies
- 1877 Views
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Last post by bromley
Tue Mar 07, 2006 1:55 pm
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MBP8298 Encouraging Results
by
Dunmann » Tue Mar 07, 2006 8:03 am
Very encouraging results for disease progression from its phase II study! Hopefully this pans out with the phase II/III which they are now...
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- 1515 Views
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Last post by Dunmann
Tue Mar 07, 2006 8:03 am
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NNZ-2566
by
bromley » Mon Mar 06, 2006 10:44 am
I have previously posted articles relating to Neuren Pharmaceuticals. Much of their research focuses on neuro-protection. Their website states that:...
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- 1605 Views
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Last post by bromley
Mon Mar 06, 2006 10:44 am
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Genomed
Replies: 3
by
bromley » Fri Feb 24, 2006 3:51 am
First post
Dignan,
Hadn't heard of this one. I'm always wary of trial with one person. I love the bit that say's GenoMed conducts trials for free, and then...
Last post
I felt pretty much the same, watching those two videos. Almost like a bad commertial...
- 3 Replies
- 2272 Views
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Last post by Damjan
Sun Mar 05, 2006 12:24 am
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Rituximab / Rituxin
Replies: 4
by
bromley » Thu Mar 02, 2006 1:43 pm
First post
I have posted before on Rituximab which is being trialled in PP, SP and RR MS. The FDA has just approved Rituximab for Rheumatoid Arthritis....
Last post
Hi Bromley, if you are still there.
Unfortunately, you seem to have misinterpreted me. No-one suggested that you had a financial interest in...
- 4 Replies
- 3022 Views
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Last post by Brainteaser
Fri Mar 03, 2006 4:08 pm
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symadex
by
bromley » Fri Feb 24, 2006 7:32 am
Saw this one on the BCP site.
- 0 Replies
- 1926 Views
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Last post by bromley
Fri Feb 24, 2006 7:32 am
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Betaseron for CIS
by
bromley » Fri Feb 24, 2006 4:03 am
These stories make me angry and happy at the same tiime. In the last year the CRAB manufacturers have tried to convince us that their therapies...
- 0 Replies
- 2016 Views
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Last post by bromley
Fri Feb 24, 2006 4:03 am
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laquinimod
by
bromley » Tue Feb 21, 2006 7:34 am
From memory this drug is in human trials but they are still testing it on mice, with the usual good results.
But I think what they are trying to say...
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- 2011 Views
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Last post by bromley
Tue Feb 21, 2006 7:34 am
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- 1944 Views
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Last post by viper498
Mon Feb 13, 2006 7:14 am
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Nutra Pharma reports Preclincal
Replies: 3
by
backpackerusa » Thu Feb 09, 2006 8:21 am
First post
here is an important paragraph from their press release -- you can find the whole release on their site at --
The study was conducted by...
Last post
Don't get me wrong, I'm glad that nothing has stopped its progress in trials so far. It's just that we all love to hate the CRABs and now I'm not all...
- 3 Replies
- 2262 Views
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Last post by dignan
Sat Feb 11, 2006 8:53 am
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Neurovax update
by
dignan » Wed Feb 08, 2006 1:37 pm
The Immune Response Corporation Announces New Business Strategy; Emphasizes Focus on Promising MS Treatment and Second Generation HIV Therapy...
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- 1950 Views
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Last post by dignan
Wed Feb 08, 2006 1:37 pm
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Anti-inflammatory
Replies: 1
by
bromley » Wed Feb 08, 2006 1:58 am
First post
Only trialled on mice, may not reach the market until 5-10 years time.
But could be another move in the right direction.
Inflammatory diseases...
Last post
and here's a little more about the actual drug (which I suppose will be part of pre-clinical on the list)
Neutrazumab - a C5a Receptor antagonist...
- 1 Replies
- 1994 Views
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Last post by dignan
Wed Feb 08, 2006 8:35 am
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Update on MBP8298
by
bromley » Wed Feb 08, 2006 2:39 am
Doesn't really say much about the effectiveness of the tratment
BioMS Medical's pivotal Multiple Sclerosis trial receives third positive review...
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- 1977 Views
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Last post by bromley
Wed Feb 08, 2006 2:39 am
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- 1911 Views
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Last post by dignan
Mon Feb 06, 2006 8:47 am
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Hype? Rituximab
Replies: 3
by
bromley » Sat Jan 28, 2006 1:36 pm
First post
As we all know there are multitudes of drugs in trial.
Rituximab is being trialled with RR, SP and PP sufferers. Although other threads have...
Last post
Dear all,
Given the good results reported from the use of Rituximab, I e-mailed one of the neuros I had seen (one of the top MS neuros in the UK) to...
- 3 Replies
- 2692 Views
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Last post by bromley
Thu Feb 02, 2006 12:26 am
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FDA Makes Earliest Stages Of Clinical Trials More Efficient
Replies: 2
by
dignan » Mon Jan 16, 2006 11:00 am
First post
An interesting FDA development that could speed the drug approval process in the US...
FDA Issues Advice to Make Earliest Stages Of Clinical Drug...
Last post
Here's a recent article from the Center for Medical Consumers on the Perils of Speedy Drug Approval . It covers related information, e.g., the effect...
- 2 Replies
- 2409 Views
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Last post by NHE
Wed Jan 25, 2006 3:04 pm
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Anyone Using Cellcept?
Replies: 2
by
JohnGault » Wed Jan 18, 2006 10:58 pm
First post
I have been on Cellcept (2g daily) for over a year now. I also take Avonex. This has coincided with a quiet period in my MS but I do not know if I...
Last post
Thank you Kostas. Nice to know I there are others out there trying Cellcept. I am no medical expert, but if you read the pharma description of...
- 2 Replies
- 2901 Views
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Last post by JohnGault
Mon Jan 23, 2006 12:08 pm
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Anyone Using IVIGs?
Replies: 1
by
JohnGault » Wed Jan 18, 2006 11:01 pm
First post
My neuro has suggested IVIG (intravenous immunoglobulins) for my MS.
I have seen some information out there on the internet about IVIG used for MS...
Last post
I used to be on it. It worked well. I'm noot on it anymore simply because me disease progressed. It is called liquid gold at my infusion center.
- 1 Replies
- 1993 Views
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Last post by tntagg
Thu Jan 19, 2006 3:11 pm
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HSCT
by
bromley » Fri Jan 13, 2006 9:15 am
Like many I want to halt this curse until some better treatments come along. I share the views of this guy who posted on the BCP site:
HSCT
This...
- 0 Replies
- 1734 Views
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Last post by bromley
Fri Jan 13, 2006 9:15 am
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MS drugs
Replies: 4
by
bromley » Thu Jan 12, 2006 12:49 pm
First post
Dear all,
The UK has an MS website called MSRC. They have a list of drugs (licenced and it trial) on the site. The list isn't anywhere near as...
Last post
Brownsfan,
I think you're right about it's availability. Since they are doing a Phase II/III trial for PPMS right now, I would assume that this trial...
- 4 Replies
- 2928 Views
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Last post by dignan
Thu Jan 12, 2006 5:56 pm
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- 0 Replies
- 1529 Views
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Last post by bromley
Wed Jan 11, 2006 9:23 am
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CCR2 antagonists
Replies: 10
by
carolew » Thu Dec 08, 2005 4:43 am
First post
They are offering me a study on this now. Does anyone know of this category of meds. I read a bit on them on the net. They have one made by Pfizer...
Last post
John's cholesterol is fine at this point and actually when he was first started on it he hadn't had his checked. Ask your Doctor. If he says no look...
- 10 Replies
- 3167 Views
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Last post by Melody
Wed Jan 11, 2006 8:30 am
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Rituximab
by
bromley » Wed Jan 11, 2006 8:08 am
Statement on Rutuximab from NMSS
- 0 Replies
- 1849 Views
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Last post by bromley
Wed Jan 11, 2006 8:08 am
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Rituxan Phase III for PPMS
by
dignan » Tue Jan 10, 2006 3:43 pm
I thought this was a typo a week or two ago when I saw mention of the latest Rituxan trial for PPMS being a Phase III trial, but this exerpt from a...
- 0 Replies
- 2212 Views
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Last post by dignan
Tue Jan 10, 2006 3:43 pm
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HP184
Replies: 1
by
dignan » Mon Jan 09, 2006 9:14 am
First post
Here's a drug (Sanofi-aventis' HP184) in the early stages that might be helpful for MS and other conditions.
Tireless quest for a cure,...
Last post
The UK MS society is focusing on the issue of sodium and potassium channel blockers and are trialling one drug.
'MS Frontiers 2005 - Trials of...
- 1 Replies
- 2674 Views
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Last post by bromley
Mon Jan 09, 2006 9:25 am
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A new angle: using RNA
by
dignan » Sat Jan 07, 2006 4:26 pm
This sounds like a different way of treating MS that has potential.
A Novel Method of Modifying Immune Responses By Vaccination With...
- 0 Replies
- 1572 Views
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Last post by dignan
Sat Jan 07, 2006 4:26 pm
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- 3 Replies
- 2343 Views
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Last post by dignan
Thu Jan 05, 2006 5:56 pm
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EPO
by
dignan » Thu Dec 22, 2005 3:47 pm
EPO is in pre-clinical studies for MS. This abstract talks about a modified version that would possibly have fewer side effects...
Delayed...
- 0 Replies
- 1808 Views
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Last post by dignan
Thu Dec 22, 2005 3:47 pm
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Prognosis for future patients
Replies: 16
by
Brownsfan » Wed Dec 07, 2005 11:34 am
First post
Is the general feeling that those who will be diagnosed 5 years from today will benefit greatly from todays drug pipeline and perhaps never see any...
Last post
Interesting stuff for Alzheimer's! I need to read more on that.
I probably should have mentioned this in my prior post but better late than never....
- 16 Replies
- 5578 Views
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Last post by NHE
Thu Dec 22, 2005 1:49 am
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BHT-3009
Replies: 1
by
dignan » Mon Dec 19, 2005 7:31 am
First post
This is old news, but Bayhill just decided to do this press release I guess...
Scientists Demonstrate Investigational MS Drug Down Regulates the...
Last post
Dignan,
Interesting post - seems similar to Tovaxin in its approach. It's a pity that so many companies are working away in their labs on their own,...
- 1 Replies
- 3083 Views
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Last post by bromley
Mon Dec 19, 2005 11:50 am
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- 0 Replies
- 1857 Views
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Last post by backpacker2006
Mon Dec 19, 2005 9:06 am
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