A forum to discuss research on the origins of MS and its development.
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Some MS cases could be due to bacteria
by
frodo » Sun Jun 13, 2021 6:33 am
Spinal fluid IgG antibodies from patients with demyelinating diseases bind multiple sclerosis-associated bacteria
Abstract
A panel of 10 IgG...
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- 29 Views
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Last post by frodo
Sun Jun 13, 2021 6:33 am
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- 97 Views
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Last post by frodo
Mon May 31, 2021 3:27 am
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More evidence against EBV
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frodo » Sat May 22, 2021 11:07 am
Exosomes From Subjects With Multiple Sclerosis Express EBV-Derived Proteins and Activate Monocyte-Derived Macrophages
Abstract
Objective To...
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- 158 Views
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Last post by frodo
Sat May 22, 2021 11:07 am
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B Cell Dysfunction, Aging, Autoimmune Diseases
Replies: 6
by
jimmylegs » Fri May 14, 2021 11:35 am
First post
starting to work on getting my head around anti b cell meds...
B Cell Dysfunction Associated With Aging and Autoimmune Diseases (2019)
fft:
......
Last post
guess who? mice...
Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in...
- 6 Replies
- 275 Views
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Last post by jimmylegs
Mon May 17, 2021 2:54 am
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Microglia in the pathogenesis of MS
Replies: 22
by
frodo » Mon Jul 23, 2018 11:13 am
First post
Microglia in the pathogenesis of MS
We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...
Last post
2021 May 5
Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands
Multiple sclerosis is linked to MAPK ERK...
- 22 Replies
- 4085 Views
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Last post by Petr75
Thu May 06, 2021 5:28 am
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MS as a metabolic disease
by
frodo » Mon May 03, 2021 2:23 am
Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than...
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- 184 Views
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Last post by frodo
Mon May 03, 2021 2:23 am
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- 183 Views
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Last post by frodo
Wed Apr 28, 2021 2:08 am
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Surface-in pathology
by
Petr75 » Wed Apr 21, 2021 3:42 am
2021 Apr 20
NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London, Institute of Neurology, London, UK
Surface-in...
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- 188 Views
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Last post by Petr75
Wed Apr 21, 2021 3:42 am
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Adolescent infection increases MS risk
by
NHE » Thu Apr 08, 2021 3:01 am
Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis
Brain. 2021 Mar 9;awab100.
The involvement of...
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- 168 Views
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Last post by NHE
Thu Apr 08, 2021 3:01 am
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- 2 Replies
- 877 Views
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Last post by DIM
Thu Apr 01, 2021 10:18 am
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QSM-MRI can show brain inflammation.
by
frodo » Tue Mar 16, 2021 10:55 am
QSM-MRI can show brain inflammation. Currently there is none.
QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions...
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- 186 Views
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Last post by frodo
Tue Mar 16, 2021 10:55 am
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MS transcriptome analysis
Replies: 1
by
jimmylegs » Fri Mar 12, 2021 8:59 am
First post
things about which i know nothing:
Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing...
Last post
looks like they are trying to separate RRMS from SPMS
- 1 Replies
- 205 Views
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Last post by frodo
Tue Mar 16, 2021 10:47 am
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Biomarkers. Extensive review as of 2021
by
frodo » Mon Mar 08, 2021 8:32 pm
Biomarkers in Multiple sclerosis: what place for oxysterols?
The main markers of multiple sclerosis that have been identified are involved in the...
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- 202 Views
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Last post by frodo
Mon Mar 08, 2021 8:32 pm
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MicroRNA in MS and other diseases
by
frodo » Mon Mar 08, 2021 8:17 pm
MiRNA dysregulation multiple sclerosis
MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to...
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- 204 Views
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Last post by frodo
Mon Mar 08, 2021 8:17 pm
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Teri helps recovering optic nerve
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frodo » Mon Mar 08, 2021 8:02 pm
Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis
Beneficial properties of TRF beyond pure...
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- 196 Views
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Last post by frodo
Mon Mar 08, 2021 8:02 pm
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TNF demyelination considered as MS
by
frodo » Wed Feb 24, 2021 2:05 am
TNF-α blockers-associated multiple sclerosis
Conclusion
Our study confirmed that the exposure to TNFα blockers can be associated to a broad...
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- 249 Views
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Last post by frodo
Wed Feb 24, 2021 2:05 am
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EBV theory of MS. Some diagrams.
Replies: 1
by
frodo » Sat Feb 20, 2021 3:39 am
First post
A new paper about how EBV could lead to MS. I link the main diagram here below.
Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging...
Last post
Here's the full paper...
Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies
Trends Mol Med. 2020 Mar;26(3):296-310....
- 1 Replies
- 257 Views
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Last post by NHE
Sat Feb 20, 2021 7:21 am
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Myelin disruption precedes autoimmunity in NAWM
Replies: 1
by
NHE » Wed Feb 10, 2021 2:52 pm
First post
Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Ann Neurol. 2021 Jan 6.
Objective: Multiple sclerosis (MS) is a...
Last post
thanks. interesting.
- 1 Replies
- 329 Views
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Last post by frodo
Sat Feb 20, 2021 3:41 am
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- 231 Views
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Last post by frodo
Mon Feb 08, 2021 11:02 am
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- 234 Views
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Last post by frodo
Mon Feb 08, 2021 10:55 am
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plasmablast: 100% specificity
by
frodo » Mon Feb 08, 2021 10:51 am
Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases.
Summary...
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- 191 Views
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Last post by frodo
Mon Feb 08, 2021 10:51 am
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A unified view of multiple sclerosis
by
frodo » Sat Jan 30, 2021 3:48 am
A unified view of multiple sclerosis
Abstract
The clinical course of multiple sclerosis (MS)is highly variable. To establish a standardized...
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- 680 Views
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Last post by frodo
Sat Jan 30, 2021 3:48 am
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- 391 Views
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Last post by frodo
Tue Jan 26, 2021 12:56 pm
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- 349 Views
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Last post by frodo
Fri Jan 22, 2021 10:59 pm
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- 320 Views
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Last post by frodo
Fri Jan 22, 2021 10:52 pm
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miRNA dysregulation as the source of the disease
Replies: 15
by
frodo » Mon Oct 16, 2017 11:28 pm
First post
Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...
Last post
2021 Jan 16
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Identification of...
- 15 Replies
- 3041 Views
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Last post by Petr75
Mon Jan 18, 2021 11:56 pm
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serum biomarkers: Phospholipids
by
frodo » Wed Jan 13, 2021 5:31 am
Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis
Conclusion
From this study, we can...
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- 313 Views
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Last post by frodo
Wed Jan 13, 2021 5:31 am
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- 336 Views
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Last post by frodo
Tue Jan 12, 2021 10:40 am
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- 306 Views
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Last post by frodo
Tue Jan 12, 2021 9:05 am
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subtyping RRMS
by
frodo » Tue Jan 05, 2021 3:00 pm
Subtyping relapsing–remitting multiple sclerosis using structural MRI
Abstract
Background and purpose
Subtyping relapsing–remitting multiple...
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- 261 Views
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Last post by frodo
Tue Jan 05, 2021 3:00 pm
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Dogs can smell MS
Replies: 3
by
frodo » Wed Dec 04, 2019 12:54 am
First post
These Dogs Know When Their Owners Are About to Have an MS Flare
Health and wellness touch everyone’s life differently. Here are some stories....
Last post
Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study
Abstract
Objective: In the present study we investigated whether...
- 3 Replies
- 751 Views
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Last post by frodo
Tue Dec 22, 2020 12:27 pm
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Herpes simplex virus
by
Petr75 » Tue Dec 22, 2020 12:07 am
2020 Nov 19
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Positive...
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- 235 Views
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Last post by Petr75
Tue Dec 22, 2020 12:07 am
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MRZ Reaction in PPMS
by
frodo » Tue Dec 01, 2020 5:45 am
Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis
Abstract
The MRZ reaction (MRZR)...
- 0 Replies
- 409 Views
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Last post by frodo
Tue Dec 01, 2020 5:45 am
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- 0 Replies
- 339 Views
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Last post by frodo
Tue Dec 01, 2020 5:37 am
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lipid metabolism and MS
by
frodo » Wed Nov 18, 2020 12:40 am
Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis
Abstract
Multiple sclerosis is a...
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- 320 Views
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Last post by frodo
Wed Nov 18, 2020 12:40 am
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- 0 Replies
- 309 Views
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Last post by frodo
Thu Nov 12, 2020 4:04 am
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MBP in saliva as biomarker
by
frodo » Tue Nov 10, 2020 5:13 am
Serum and saliva Myelin basic protein as Multiple sclerosis biomarker
Abstract:
Objective: Multiple sclerosis (MS) is considered as motor and...
- 0 Replies
- 272 Views
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Last post by frodo
Tue Nov 10, 2020 5:13 am
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- 0 Replies
- 298 Views
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Last post by frodo
Fri Nov 06, 2020 5:09 am
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- 0 Replies
- 276 Views
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Last post by frodo
Fri Nov 06, 2020 2:45 am
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- 0 Replies
- 286 Views
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Last post by frodo
Tue Nov 03, 2020 6:09 am
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- 0 Replies
- 314 Views
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Last post by frodo
Tue Nov 03, 2020 6:07 am
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MS biomarker in serum
by
frodo » Tue Nov 03, 2020 6:04 am
Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging
Abstract
Multiple...
- 0 Replies
- 278 Views
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Last post by frodo
Tue Nov 03, 2020 6:04 am
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Complex genetic signatures
by
Petr75 » Wed Oct 14, 2020 8:35 am
2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...
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- 293 Views
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Last post by Petr75
Wed Oct 14, 2020 8:35 am
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- 0 Replies
- 430 Views
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Last post by frodo
Fri Oct 09, 2020 7:12 am
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specific CSF biomarkers review
by
frodo » Fri Oct 02, 2020 6:11 am
CSF biomarkers in multiple sclerosis: beyond neuroinflammation
making a long story short:
Diagnostic biomarkers: IgG oligoclonal bands, IgG...
- 0 Replies
- 340 Views
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Last post by frodo
Fri Oct 02, 2020 6:11 am
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lipids differentiate PPMS and SPMS
by
frodo » Fri Oct 02, 2020 4:47 am
Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis
Abstract...
- 0 Replies
- 334 Views
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Last post by frodo
Fri Oct 02, 2020 4:47 am
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OCBs can separate MS from lyme
by
frodo » Thu Oct 01, 2020 6:44 am
Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi
Background
Cerebrospinal fluid (CSF)...
- 0 Replies
- 364 Views
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Last post by frodo
Thu Oct 01, 2020 6:44 am
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EBNA1 (EBV protein) reactive to OCBs
by
frodo » Fri Sep 25, 2020 7:21 am
Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...
- 0 Replies
- 345 Views
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Last post by frodo
Fri Sep 25, 2020 7:21 am
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biomarkers review
by
frodo » Tue Sep 22, 2020 11:21 am
Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis
Background
Verification of...
- 0 Replies
- 346 Views
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Last post by frodo
Tue Sep 22, 2020 11:21 am
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Creatine metabolic alterations in MS
by
frodo » Thu Sep 17, 2020 6:55 am
Creatine and multiple sclerosis
ABSTRACT
Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...
- 0 Replies
- 372 Views
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Last post by frodo
Thu Sep 17, 2020 6:55 am
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