MS Etiology and Pathogenesis

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Microglia in the pathogenesis of MS

Last post by Petr75 « Thu May 06, 2021 5:28 am
Replies: 22
by frodo » Mon Jul 23, 2018 11:13 am
1

2
First post

Microglia in the pathogenesis of MS

We postulate that the immune reaction initiates in the CNS and immune cells (including T cells/B cell)...

Last post

2021 May 5
Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands
Multiple sclerosis is linked to MAPK ERK...
22 Replies

3807 Views

Last post by Petr75
Thu May 06, 2021 5:28 am
MS as a metabolic disease

Last post by frodo « Mon May 03, 2021 2:23 am

by frodo » Mon May 03, 2021 2:23 am

Pathology-supported genetic testing as a method for disability prevention in multiple sclerosis (MS). Part I. Targeting a metabolic model rather than...

0 Replies

65 Views

Last post by frodo
Mon May 03, 2021 2:23 am
automatic diagnosis of CNS diseases

Last post by frodo « Wed Apr 28, 2021 2:08 am

by frodo » Wed Apr 28, 2021 2:08 am

CSF biomarkers, processed by an algorithm, can help establishing an automatic diagnosis of CNS diseases.

0 Replies

72 Views

Last post by frodo
Wed Apr 28, 2021 2:08 am
Surface-in pathology

Last post by Petr75 « Wed Apr 21, 2021 3:42 am

by Petr75 » Wed Apr 21, 2021 3:42 am

2021 Apr 20
NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London, Institute of Neurology, London, UK
Surface-in...

0 Replies

115 Views

Last post by Petr75
Wed Apr 21, 2021 3:42 am
Adolescent infection increases MS risk

Last post by NHE « Thu Apr 08, 2021 3:01 am

by NHE » Thu Apr 08, 2021 3:01 am

Hospital-diagnosed infections before age 20 and risk of a subsequent multiple sclerosis diagnosis
Brain. 2021 Mar 9;awab100.

The involvement of...

0 Replies

144 Views

Last post by NHE
Thu Apr 08, 2021 3:01 am
Herpesvirus HHV-6B strain linked to MS

Last post by DIM « Thu Apr 01, 2021 10:18 am
Replies: 2
by frodo » Tue Dec 10, 2019 3:52 am

2 Replies

843 Views

Last post by DIM
Thu Apr 01, 2021 10:18 am
QSM-MRI can show brain inflammation.

Last post by frodo « Tue Mar 16, 2021 10:55 am

by frodo » Tue Mar 16, 2021 10:55 am

QSM-MRI can show brain inflammation. Currently there is none.

QSM is an imaging biomarker for chronic glial activation inmultiple sclerosis lesions...

0 Replies

163 Views

Last post by frodo
Tue Mar 16, 2021 10:55 am
MS transcriptome analysis

Last post by frodo « Tue Mar 16, 2021 10:47 am
Replies: 1
by jimmylegs » Fri Mar 12, 2021 8:59 am

First post

things about which i know nothing:

Whole transcriptome analysis of multiple Sclerosis patients reveals active inflammatory profile in relapsing...

Last post

looks like they are trying to separate RRMS from SPMS

1 Replies

185 Views

Last post by frodo
Tue Mar 16, 2021 10:47 am
Biomarkers. Extensive review as of 2021

Last post by frodo « Mon Mar 08, 2021 8:32 pm

by frodo » Mon Mar 08, 2021 8:32 pm

Biomarkers in Multiple sclerosis: what place for oxysterols?

The main markers of multiple sclerosis that have been identified are involved in the...

0 Replies

181 Views

Last post by frodo
Mon Mar 08, 2021 8:32 pm
MicroRNA in MS and other diseases

Last post by frodo « Mon Mar 08, 2021 8:17 pm

by frodo » Mon Mar 08, 2021 8:17 pm

MiRNA dysregulation multiple sclerosis

MiRNAs dysregulation display strong association with multiple sclerosis (MS). Several MiRNAs were reported to...

0 Replies

180 Views

Last post by frodo
Mon Mar 08, 2021 8:17 pm
Teri helps recovering optic nerve

Last post by frodo « Mon Mar 08, 2021 8:02 pm

by frodo » Mon Mar 08, 2021 8:02 pm

Teriflunomide treatment is associated with optic nerve recovery in early multiple sclerosis

Beneficial properties of TRF beyond pure...

0 Replies

167 Views

Last post by frodo
Mon Mar 08, 2021 8:02 pm
TNF demyelination considered as MS

Last post by frodo « Wed Feb 24, 2021 2:05 am

by frodo » Wed Feb 24, 2021 2:05 am

TNF-α blockers-associated multiple sclerosis

Conclusion

Our study confirmed that the exposure to TNFα blockers can be associated to a broad...

0 Replies

226 Views

Last post by frodo
Wed Feb 24, 2021 2:05 am
EBV theory of MS. Some diagrams.

Last post by NHE « Sat Feb 20, 2021 7:21 am
Replies: 1
by frodo » Sat Feb 20, 2021 3:39 am

First post

A new paper about how EBV could lead to MS. I link the main diagram here below.

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging...

Last post

Here's the full paper...

Epstein-Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies
Trends Mol Med. 2020 Mar;26(3):296-310....

1 Replies

235 Views

Last post by NHE
Sat Feb 20, 2021 7:21 am
Myelin disruption precedes autoimmunity in NAWM

Last post by frodo « Sat Feb 20, 2021 3:41 am
Replies: 1
by NHE » Wed Feb 10, 2021 2:52 pm

First post

Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
Ann Neurol. 2021 Jan 6.

Objective: Multiple sclerosis (MS) is a...

Last post

thanks. interesting.

1 Replies

305 Views

Last post by frodo
Sat Feb 20, 2021 3:41 am
The lancet: More about the previous two epitopes

Last post by frodo « Mon Feb 08, 2021 11:02 am

by frodo » Mon Feb 08, 2021 11:02 am

Serum markers of multiple sclerosis - a new approach

Optic neuritis (ON) typically manifests with the classical triad of subacute unilateral...

0 Replies

202 Views

Last post by frodo
Mon Feb 08, 2021 11:02 am
Biomarkers: Two epitopes predict ON evolution to MS

Last post by frodo « Mon Feb 08, 2021 10:55 am

by frodo » Mon Feb 08, 2021 10:55 am

You can see what a epitope is at wikipedia:

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis...

0 Replies

210 Views

Last post by frodo
Mon Feb 08, 2021 10:55 am
plasmablast: 100% specificity

Last post by frodo « Mon Feb 08, 2021 10:51 am

by frodo » Mon Feb 08, 2021 10:51 am

Plasmablast ( immature blood cells ) reported to have 36% sensivity and 100% specificity compared to other neurological diseases.

Summary...

0 Replies

168 Views

Last post by frodo
Mon Feb 08, 2021 10:51 am
A unified view of multiple sclerosis

Last post by frodo « Sat Jan 30, 2021 3:48 am

by frodo » Sat Jan 30, 2021 3:48 am

A unified view of multiple sclerosis

Abstract

The clinical course of multiple sclerosis (MS)is highly variable. To establish a standardized...

0 Replies

654 Views

Last post by frodo
Sat Jan 30, 2021 3:48 am
Biomarkers: Two new ones related to EBV

Last post by frodo « Tue Jan 26, 2021 12:56 pm

by frodo » Tue Jan 26, 2021 12:56 pm

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients

0 Replies

367 Views

Last post by frodo
Tue Jan 26, 2021 12:56 pm
Nature: MRI can show biological heterogeneity

Last post by frodo « Fri Jan 22, 2021 10:59 pm

by frodo » Fri Jan 22, 2021 10:59 pm

Quantitative MRI phenotypes capture biological heterogeneity in multiple sclerosis patients

Abstract

Magnetization transfer ratio (MTR) and...

0 Replies

326 Views

Last post by frodo
Fri Jan 22, 2021 10:59 pm
Ibudilast for PPMS better than for SPMS

Last post by frodo « Fri Jan 22, 2021 10:52 pm

by frodo » Fri Jan 22, 2021 10:52 pm

Response to ibudilast treatment according to progressive multiple sclerosis disease phenotype

Discussion

The impetus to study ibudilast in...

0 Replies

293 Views

Last post by frodo
Fri Jan 22, 2021 10:52 pm
miRNA dysregulation as the source of the disease

Last post by Petr75 « Mon Jan 18, 2021 11:56 pm
Replies: 15
by frodo » Mon Oct 16, 2017 11:28 pm
1

2
First post

Micro-RNA ( miRNA ) has been proposed as a biomarker of axon degeneration, but some authors have proposed that they could be the source of the...

Last post

2021 Jan 16
Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Identification of...
15 Replies

2963 Views

Last post by Petr75
Mon Jan 18, 2021 11:56 pm
serum biomarkers: Phospholipids

Last post by frodo « Wed Jan 13, 2021 5:31 am

by frodo » Wed Jan 13, 2021 5:31 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Conclusion

From this study, we can...

0 Replies

287 Views

Last post by frodo
Wed Jan 13, 2021 5:31 am
Western lifestyle: Possible link to antibiotics consumption

Last post by frodo « Tue Jan 12, 2021 10:40 am

by frodo » Tue Jan 12, 2021 10:40 am

Holistic solution to an old mystery : the global role of antibiotic consumption patterns in the spread of certain non-contagious diseases in EU...

0 Replies

311 Views

Last post by frodo
Tue Jan 12, 2021 10:40 am
New medical entity overlapping with MS: DAF

Last post by frodo « Tue Jan 12, 2021 9:05 am

by frodo » Tue Jan 12, 2021 9:05 am

After NMO and anti-MOG, and following the non-autoimmune models of MS, it seems that there is a new entity entering the scene:

Demyelination with...

0 Replies

286 Views

Last post by frodo
Tue Jan 12, 2021 9:05 am
subtyping RRMS

Last post by frodo « Tue Jan 05, 2021 3:00 pm

by frodo » Tue Jan 05, 2021 3:00 pm

Subtyping relapsing–remitting multiple sclerosis using structural MRI

Abstract
Background and purpose

Subtyping relapsing–remitting multiple...

0 Replies

237 Views

Last post by frodo
Tue Jan 05, 2021 3:00 pm
Dogs can smell MS

Last post by frodo « Tue Dec 22, 2020 12:27 pm
Replies: 3
by frodo » Wed Dec 04, 2019 12:54 am

First post

These Dogs Know When Their Owners Are About to Have an MS Flare

Health and wellness touch everyone’s life differently. Here are some stories....

Last post

Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study

Abstract

Objective: In the present study we investigated whether...

3 Replies

729 Views

Last post by frodo
Tue Dec 22, 2020 12:27 pm
Herpes simplex virus

Last post by Petr75 « Tue Dec 22, 2020 12:07 am

by Petr75 » Tue Dec 22, 2020 12:07 am

2020 Nov 19
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China
Positive...

0 Replies

208 Views

Last post by Petr75
Tue Dec 22, 2020 12:07 am
MRZ Reaction in PPMS

Last post by frodo « Tue Dec 01, 2020 5:45 am

by frodo » Tue Dec 01, 2020 5:45 am

Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis

Abstract

The MRZ reaction (MRZR)...

0 Replies

380 Views

Last post by frodo
Tue Dec 01, 2020 5:45 am
Iron heterogeneity in MS: Patterns can be separated!!

Last post by frodo « Tue Dec 01, 2020 5:37 am

by frodo » Tue Dec 01, 2020 5:37 am

Iron heterogeneity in early active multiple sclerosis lesions.

Abstract

OBJECTIVE :

Multiple sclerosis (MS) is a heterogeneous inflammatory...

0 Replies

318 Views

Last post by frodo
Tue Dec 01, 2020 5:37 am
lipid metabolism and MS

Last post by frodo « Wed Nov 18, 2020 12:40 am

by frodo » Wed Nov 18, 2020 12:40 am

Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis

Abstract

Multiple sclerosis is a...

0 Replies

295 Views

Last post by frodo
Wed Nov 18, 2020 12:40 am
Twins comparison suggest lipids metabolism implications

Last post by frodo « Thu Nov 12, 2020 4:04 am

by frodo » Thu Nov 12, 2020 4:04 am

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis

Abstract

Blood biomarkers of multiple sclerosis (MS) can provide a...

0 Replies

280 Views

Last post by frodo
Thu Nov 12, 2020 4:04 am
MBP in saliva as biomarker

Last post by frodo « Tue Nov 10, 2020 5:13 am

by frodo » Tue Nov 10, 2020 5:13 am

Serum and saliva Myelin basic protein as Multiple sclerosis biomarker

Abstract:

Objective: Multiple sclerosis (MS) is considered as motor and...

0 Replies

249 Views

Last post by frodo
Tue Nov 10, 2020 5:13 am
type-1 diabetes and MS. New kind of cells discovered.

Last post by frodo « Fri Nov 06, 2020 5:09 am

by frodo » Fri Nov 06, 2020 5:09 am

Newly Discovered Hybrid Immune Cell Could Finally Explain The Cause of Type 1 Diabetes

Both the peptide and hybrid white cells were more likely...

0 Replies

274 Views

Last post by frodo
Fri Nov 06, 2020 5:09 am
New microglial modulator inhibits activated microglia

Last post by frodo « Fri Nov 06, 2020 2:45 am

by frodo » Fri Nov 06, 2020 2:45 am

The new modulator inhibits something called CSF1R and it has been shown to reduce altered microglia. They also say that NAWM microglia shows an...

0 Replies

251 Views

Last post by frodo
Fri Nov 06, 2020 2:45 am
changes in NAWM precede lesion development

Last post by frodo « Tue Nov 03, 2020 6:09 am

by frodo » Tue Nov 03, 2020 6:09 am

Role of Magnetic Resonance Imaging with Diffusion Sequences in Assessment of Multiple Sclerosis in Brain Versus Normally Appearing White Matter...

0 Replies

262 Views

Last post by frodo
Tue Nov 03, 2020 6:09 am
Retinal damage reflects MS progression, not relapses

Last post by frodo « Tue Nov 03, 2020 6:07 am

by frodo » Tue Nov 03, 2020 6:07 am

Retinal layer thinning is reflecting disability progression independent of relapse activity in multiple sclerosis

Background
PIRA (progression...

0 Replies

280 Views

Last post by frodo
Tue Nov 03, 2020 6:07 am
MS biomarker in serum

Last post by frodo « Tue Nov 03, 2020 6:04 am

by frodo » Tue Nov 03, 2020 6:04 am

Detection of Multiple Sclerosis Biomarkers in Serum by Ganglioside Microarrays and Surface Plasmon Resonance Imaging

Abstract

Multiple...

0 Replies

250 Views

Last post by frodo
Tue Nov 03, 2020 6:04 am
Complex genetic signatures

Last post by Petr75 « Wed Oct 14, 2020 8:35 am

by Petr75 » Wed Oct 14, 2020 8:35 am

2020 Oct
Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy
Complex genetic signatures in immune...

0 Replies

272 Views

Last post by Petr75
Wed Oct 14, 2020 8:35 am
Focus on microglia again: TSPO-PET predicts progression.

Last post by frodo « Fri Oct 09, 2020 7:12 am

by frodo » Fri Oct 09, 2020 7:12 am

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Abstract

Overactivation of microglia is...

0 Replies

410 Views

Last post by frodo
Fri Oct 09, 2020 7:12 am
specific CSF biomarkers review

Last post by frodo « Fri Oct 02, 2020 6:11 am

by frodo » Fri Oct 02, 2020 6:11 am

CSF biomarkers in multiple sclerosis: beyond neuroinflammation

making a long story short:

Diagnostic biomarkers: IgG oligoclonal bands, IgG...

0 Replies

321 Views

Last post by frodo
Fri Oct 02, 2020 6:11 am
lipids differentiate PPMS and SPMS

Last post by frodo « Fri Oct 02, 2020 4:47 am

by frodo » Fri Oct 02, 2020 4:47 am

Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis

Abstract...

0 Replies

309 Views

Last post by frodo
Fri Oct 02, 2020 4:47 am
OCBs can separate MS from lyme

Last post by frodo « Thu Oct 01, 2020 6:44 am

by frodo » Thu Oct 01, 2020 6:44 am

Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi

Background

Cerebrospinal fluid (CSF)...

0 Replies

341 Views

Last post by frodo
Thu Oct 01, 2020 6:44 am
EBNA1 (EBV protein) reactive to OCBs

Last post by frodo « Fri Sep 25, 2020 7:21 am

by frodo » Fri Sep 25, 2020 7:21 am

Antibodies from multiple sclerosis brain identified Epstein-Barr virus nuclear antigen 1 & 2 epitopes which are recognized by oligoclonal bands...

0 Replies

324 Views

Last post by frodo
Fri Sep 25, 2020 7:21 am
biomarkers review

Last post by frodo « Tue Sep 22, 2020 11:21 am

by frodo » Tue Sep 22, 2020 11:21 am

Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis

Background

Verification of...

0 Replies

322 Views

Last post by frodo
Tue Sep 22, 2020 11:21 am
Creatine metabolic alterations in MS

Last post by frodo « Thu Sep 17, 2020 6:55 am

by frodo » Thu Sep 17, 2020 6:55 am

Creatine and multiple sclerosis

ABSTRACT

Multiple sclerosis (MS) is a complex and debilitating neurodegenerative disease, with unknown...

0 Replies

344 Views

Last post by frodo
Thu Sep 17, 2020 6:55 am
Two molecular types of lesions via MRI

Last post by frodo « Mon Sep 14, 2020 1:34 am

by frodo » Mon Sep 14, 2020 1:34 am

Characterization of multiple sclerosis lesions with distinct clinical correlates through quantitative diffusion MRI

Highlights :

• Macroscopic...

0 Replies

347 Views

Last post by frodo
Mon Sep 14, 2020 1:34 am
Characteristics of multiple sclerosis in patients of Middle Eastern and North African

Last post by Petr75 « Sat Sep 05, 2020 8:40 pm

by Petr75 » Sat Sep 05, 2020 8:40 pm

2020 Aug 11
Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada/Division of Neurology,...

0 Replies

334 Views

Last post by Petr75
Sat Sep 05, 2020 8:40 pm
Three different biopsy patterns

Last post by frodo « Thu Sep 03, 2020 12:31 am

by frodo » Thu Sep 03, 2020 12:31 am

Different pathological processes for acute white matter lesions in multiple sclerosis

Abstract

Introduction :

Multiple sclerosis (MS) has...

0 Replies

301 Views

Last post by frodo
Thu Sep 03, 2020 12:31 am
A pathogenic B cell transcriptome in active multiple sclerosis

Last post by frodo « Tue Sep 01, 2020 5:25 am

by frodo » Tue Sep 01, 2020 5:25 am

A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis

Abstract

Central nervous system B cells have several...

0 Replies

273 Views

Last post by frodo
Tue Sep 01, 2020 5:25 am

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