A forum to discuss research on the origins of MS and its development.
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Last post by frodo
Wed Feb 27, 2019 3:09 am
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Last post by frodo
Wed Feb 27, 2019 2:34 am
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Last post by frodo
Thu Feb 21, 2019 6:47 pm
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Patterns thread: Selective treatment for the four patterns
Replies: 14
by
frodo » Sun Nov 26, 2017 4:04 am
First post
In this post I will try to keep track of the developments in the specific treatment of the four patterns, whose existence was at first disputed, but...
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Mitochondrial defects in acute multiple sclerosis lesions.
Multiple sclerosis is a chronic inflammatory disease, which leads to focal plaques of...
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Last post by frodo
Mon Feb 18, 2019 1:47 am
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Vascular problems in MS
Replies: 5
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frodo » Fri Aug 17, 2018 1:28 am
First post
Maybe CCSVI theory is wrong, but there must be something related to the vascular system in MS. Two more reports about vascular problems associated to...
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I meant WILL refer to. Vesta
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Last post by vesta
Mon Feb 11, 2019 12:48 am
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Last post by frodo
Wed Feb 06, 2019 2:38 am
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Last post by frodo
Tue Feb 05, 2019 11:49 pm
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Last post by frodo
Tue Feb 05, 2019 2:38 am
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maybe B-cells are not so important
Replies: 2
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frodo » Sun Feb 03, 2019 7:41 am
First post
The success of anti-CD20 monoclonal antibodies has put the focus on CD20 B-cells, but it could be that the mechanism of action is about depleting...
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I would say that for reduction of disease activity they mean relapses, not progresion.
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Last post by frodo
Sun Feb 03, 2019 9:43 am
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CSF can separate RRMS from PPMS
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frodo » Sun Feb 03, 2019 7:49 am
Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing–Remitting Multiple Sclerosis
To better understand the...
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Last post by frodo
Sun Feb 03, 2019 7:49 am
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Last post by frodo
Sun Feb 03, 2019 1:46 am
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status of the research as of 2019
by
frodo » Wed Jan 30, 2019 1:07 am
There is a review here summarising the status of knowledge:
Excerpts:
- Evidence from MRI and pathological assessment (biopsies and autopsies)...
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- 189 Views
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Last post by frodo
Wed Jan 30, 2019 1:07 am
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Last post by frodo
Mon Jan 28, 2019 7:52 am
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2018 update: Incidence and prevalence rates of Multiple Sclerosis in Canada
Replies: 2
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jimmylegs » Sun Jan 27, 2019 7:38 am
First post
PHAC releases incidence and prevalence rates of Multiple Sclerosis in Canada (2018)
Background:
The Canadian Chronic Disease Surveillance System...
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Just a remark. Prevalence rate increase could be due to a longer life and could be a good thing. Incidence rate increase is the big problem, but they...
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Last post by frodo
Mon Jan 28, 2019 6:12 am
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Last post by frodo
Wed Jan 23, 2019 6:25 am
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Biomarker for response to interferon
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frodo » Tue Jan 22, 2019 4:28 am
Semaphorin 4A as a biomarker of multiple sclerosis and neuromyelitis optica spectrum disorder
Abstract
Selecting appropriate treatment from...
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- 135 Views
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Last post by frodo
Tue Jan 22, 2019 4:28 am
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IMPORTANT: New type of MS discovered. Myelocortical MS.
Replies: 4
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frodo » Thu Aug 23, 2018 5:03 am
First post
Researchers discover new subtype of multiple sclerosis (The Lancet)
Cleveland Clinic researchers have discovered a new subtype of multiple...
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Perhaps you should research the scientific correctness of statements that you make before you post things on the board.
That statement is not...
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Last post by frodo
Sat Jan 12, 2019 9:33 am
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Wolfson Institute of Preventive Medicine. EBV is MS cause.
Replies: 1
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frodo » Sun Dec 23, 2018 5:51 am
First post
There is strong evidence that Epstein Barr Virus (EBV) infection is a cause of Multiple Sclerosis. Immunisation against
EBV could in future prevent...
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EBV and the Human Herpes Virus family activate the epigenetic pathway for the MS genetically prone.
The EBV does not cause MS.
An inflammatory...
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- 569 Views
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Last post by Kheuer
Wed Jan 09, 2019 8:50 am
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miR-223 in MS: Strong biomarker and probably pathogenic
Replies: 2
by
frodo » Fri Dec 21, 2018 6:05 am
First post
The miR-223: An Inflammatory MicroRNA Involved in Pathogenesis of Multiple Sclerosis
Full text link:
Abstract:
Multiple sclerosis (MS) is the...
Last post
Interesting. Both articles say more or less the opposite. For the first authors miR-223 is bad and for the others is good, but anyway they agree in...
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- 707 Views
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Last post by frodo
Wed Jan 09, 2019 8:23 am
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Last post by frodo
Tue Jan 08, 2019 1:09 am
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Last post by frodo
Thu Dec 27, 2018 7:21 am
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Last post by frodo
Thu Dec 27, 2018 7:18 am
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Human endogenous retro-viruses HERVs and link to diabetes
Replies: 1
by
frodo » Sun Dec 23, 2018 5:43 am
First post
Not all the research points to EBV. HERVs could be also involved.
Preclinical research demonstrated that pathogenic HERV-W protein negatively...
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Answering to myself, it seems that the HERVs retroviruses activation could be due to EBV. Therefore, it seems that all the evidence about HERV-W also...
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Last post by frodo
Thu Dec 27, 2018 7:12 am
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Last post by frodo
Tue Dec 25, 2018 9:29 am
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Atypical MS cases
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frodo » Sat Dec 22, 2018 8:40 am
Multiple Sclerosis with atypical MRI presentation: results of a nationwide multicenter study in 57 consecutive cases.
They speak about four weird...
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- 527 Views
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Last post by frodo
Sat Dec 22, 2018 8:40 am
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Last post by frodo
Sat Dec 22, 2018 8:25 am
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PPMS vs. RRMS/SPMS pathogenesis
by
frodo » Sat Dec 22, 2018 8:15 am
Pathogenic Mechanisms associated with Different Clinical Courses of Multiple Sclerosis
In the majority of patients multiple sclerosis starts with...
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- 537 Views
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Last post by frodo
Sat Dec 22, 2018 8:15 am
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Epstein Barr Virus review
by
frodo » Fri Dec 21, 2018 1:32 am
The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging
Conclusion
The conclusion drawn from...
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- 529 Views
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Last post by frodo
Fri Dec 21, 2018 1:32 am
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Biomarkers of the underlying process
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frodo » Sun Dec 09, 2018 11:07 am
Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity
HIGHLIGHTS
• Microglial/myeloid...
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Last post by frodo
Sun Dec 09, 2018 11:07 am
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Last post by frodo
Sat Dec 08, 2018 12:53 am
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Last post by frodo
Sat Dec 01, 2018 12:16 am
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FINALLY AN AUTOANTIGEN - And gut microbioma connections.
Replies: 1
by
frodo » Thu Oct 18, 2018 3:06 am
First post
Before I was completely sure about MS not being autoimmune. Well, maybe I was wrong.
Let's see if this report is confirmed.
GDP-l-fucose...
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More news about this. A clinical trial is coming up.
It seems that the autoimmune system can be re-educated. The same team in Zurich is trying to...
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Last post by frodo
Sun Oct 21, 2018 3:01 am
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what is an HLA DRB3 positive patient?
by
frodo » Fri Oct 19, 2018 11:17 am
Regarding my last post about an antigen found, it only appears in a group of patients that they call DRB3 positive. I have taken a look at what means...
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- 735 Views
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Last post by frodo
Fri Oct 19, 2018 11:17 am
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National MS society web: The word "autoimmune"dissapears.
Replies: 5
by
frodo » Mon Oct 08, 2018 9:31 am
First post
After several years saying MS is an autoimmune disease that ... now they begin like this:
Multiple sclerosis (MS) is an unpredictable, often...
Last post
related
Taking into account the results of B‐cell‐depleting drugs, the production of autoantibodies as the driving force in MS pathology has...
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Last post by jimmylegs
Wed Oct 17, 2018 12:43 pm
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Last post by frodo
Sun Oct 14, 2018 12:22 pm
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Last post by jimmylegs
Sun Sep 30, 2018 4:18 am
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Interleukin 36 in MS
by
frodo » Sat Sep 29, 2018 2:46 am
Interleukin 36 is a cytokine normally associated with psoriasis. It seems that also appears disregulated in MS. It can be meassured in blood serum...
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Last post by frodo
Sat Sep 29, 2018 2:46 am
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- 614 Views
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Last post by frodo
Wed Sep 26, 2018 5:05 am
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new diagnostic protocol proposed
Replies: 2
by
frodo » Tue Sep 25, 2018 8:31 am
First post
One of the worst problems of MS is the misdiagnosis. Given the strong side effects of some drugs neurologist wanto to be sure and delay the diagnosis...
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A few days ago you posted info on a blood test for diagnosing MS. Not sure is this new diagnostic protocol is necessary if the accuracy of the blood...
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- 813 Views
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Last post by frodo
Wed Sep 26, 2018 5:02 am
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meningeal inflammation
by
frodo » Tue Sep 25, 2018 9:23 am
Abstract
The presence of leptomeningeal inflammation (LMI) in MS was first identified in 2004 and multiple subsequent studies have confirmed the...
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- 535 Views
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Last post by frodo
Tue Sep 25, 2018 9:23 am
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Last post by jimmylegs
Sun Sep 23, 2018 12:24 pm
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Last post by frodo
Sat Sep 22, 2018 9:24 am
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- 856 Views
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Last post by Petr75
Wed Sep 19, 2018 10:05 am
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Familial MS could be different from normal MS
Replies: 1
by
frodo » Fri Aug 17, 2018 2:17 am
First post
Familial MS could be different from normal (sporadic) MS. They could be different diseases, needing different therapies, just like MS and NMO....
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Notice that it could be related to this:
A mutation in a nuclear receptor (NR1H3) gene was detected in a familial, progressive form of multiple...
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Last post by frodo
Fri Aug 24, 2018 12:06 pm
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Last post by frodo
Fri Aug 24, 2018 12:00 pm
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Multiple Sclerosis: an "EMotional" issue. The microbian code
Replies: 10
by
hmacoli » Thu Jul 12, 2018 10:32 am
First post
This is an excerpt from my last page posted in my blog about MS as an emotional issue (not only but above)…that I would like to share with you.
It...
Last post
Thanks for the additional info. I did a quick check and the machines are available here but are very, very expensive.
I am having surprisingly good...
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Last post by ElliotB
Fri Aug 24, 2018 11:02 am
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Vitamin D levels in MS impact Epstein-Barr viral load
Replies: 1
by
frodo » Thu Aug 23, 2018 7:20 am
First post
Vitamin D levels in MS impact Epstein-Barr viral load
A study, published at ECTRIMS 2017, has revealed that serum vitamin D levels could be...
Last post
lab-supported anecdote - i've used nutritional boot camp to eradicate another's chronic EBV viral load.
took a connection of mine from being in line...
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- 675 Views
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Last post by jimmylegs
Thu Aug 23, 2018 8:32 am
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Barts blog: EBV and B-cells again
by
frodo » Tue Aug 21, 2018 3:53 am
B cell Cytokines in MS brain, may support B cell follicles.
Excerpts:
Although B cell depletion is an effective therapy of multiple sclerosis...
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- 631 Views
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Last post by frodo
Tue Aug 21, 2018 3:53 am
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For researchers: Red flags in diagnosis
by
frodo » Tue Aug 21, 2018 3:47 am
Some reports point to a 10% misdiagnosis, specially due to the appearance of lesions in MRI. It seems that non-demyelinating lesions are normal and...
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- 635 Views
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Last post by frodo
Tue Aug 21, 2018 3:47 am
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Last post by frodo
Tue Aug 21, 2018 3:36 am
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