A forum to discuss research on the origins of MS and its development.
-
-
Coronavirus (COVID-19): What You Need To Know
Replies: 132
by
jimmylegs » Sun Mar 15, 2020 4:10 am » in
General Discussion
First post
What You Need To Know About Coronavirus (COVID-19)
What does COVID-19 mean for people living with MS? Many disease modifying therapies (DMTs) for...
Last post
A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19 (June 3)
...
CONCLUSIONS
After high-risk or moderate-risk...
- 132 Replies
- 11970 Views
-
Last post by jimmylegs
Wed Jun 03, 2020 6:36 pm
-
-
Smouldering lesions can be seen on MRI
Replies: 1
by
frodo » Tue Sep 24, 2019 1:34 am
First post
A paper about seen smoldering lesions on MRI here:
A previous one about the same:
An not a paper, but a blog entry instead speaking about the...
Last post
More information about the discovery
- 1 Replies
- 817 Views
-
Last post by frodo
Thu Jan 09, 2020 4:43 am
-
-
B-cell types and MS
by
frodo » Wed Jan 08, 2020 6:39 am
Induction of brain‐infiltrating T‐bet–expressing B cells in multiple sclerosis
Here, we aimed to explore the CNS transmigration capacity of...
- 0 Replies
- 503 Views
-
Last post by frodo
Wed Jan 08, 2020 6:39 am
-
-
Plasma exchange works in steroid-refractory MS
Replies: 2
by
frodo » Tue Nov 19, 2019 4:06 am
First post
Visual Outcomes of Plasma Exchange Treatment of Steroid-Refractory Optic Neuritis: A Retrospective Monocentric Analysis
Introduction :
In acute...
Last post
Comparing Plasma Exchange to Escalated Methyl Prednisolone in Refractory Multiple Sclerosis Relapses
Abstract
Intravenous methyl prednisolone...
- 2 Replies
- 549 Views
-
Last post by frodo
Fri Dec 27, 2019 12:01 pm
-
-
Biomarkers: Status at the end of 2019
by
frodo » Fri Dec 27, 2019 11:53 am
A review about the status of several MS biomarkers at the end of 2019
Conclusions
Molecular biomarkers enable individual decisions and are an...
- 0 Replies
- 487 Views
-
Last post by frodo
Fri Dec 27, 2019 11:53 am
-
-
- 0 Replies
- 433 Views
-
Last post by frodo
Thu Dec 26, 2019 10:43 am
-
-
- 0 Replies
- 363 Views
-
Last post by frodo
Thu Dec 19, 2019 5:21 am
-
-
is MS an autoimmune disease?
by
frodo » Wed Dec 18, 2019 7:19 am
This paper lists evidence for and against the autoimmune classification. It is interesting to note that one of the main reasons supporting...
- 0 Replies
- 559 Views
-
Last post by frodo
Wed Dec 18, 2019 7:19 am
-
-
Detecting early MS
by
frodo » Wed Dec 18, 2019 6:53 am
Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
Abstract
Background
Multiple...
- 0 Replies
- 367 Views
-
Last post by frodo
Wed Dec 18, 2019 6:53 am
-
-
Mitochondria in MS
Replies: 3
by
frodo » Sat Dec 16, 2017 5:11 am
First post
Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis
Last post
It is unknown (for me) wether they refer to human neurons.
- 3 Replies
- 1268 Views
-
Last post by frodo
Wed Dec 18, 2019 6:32 am
-
-
lesion evolution
by
frodo » Tue Dec 17, 2019 1:30 am
This article refers to the four possible evolutive types of lesions (active, inactive, chronic active, remyelinating)
Molecular signature of...
- 0 Replies
- 363 Views
-
Last post by frodo
Tue Dec 17, 2019 1:30 am
-
-
- 0 Replies
- 378 Views
-
Last post by frodo
Tue Dec 17, 2019 1:16 am
-
-
- 0 Replies
- 531 Views
-
Last post by frodo
Tue Dec 10, 2019 3:52 am
-
-
Dogs can smell MS
Replies: 2
by
frodo » Wed Dec 04, 2019 12:54 am
First post
These Dogs Know When Their Owners Are About to Have an MS Flare
Health and wellness touch everyone’s life differently. Here are some stories....
Last post
Using Gas Chromatography Mass Spectrometry (GC-MS) for MS diagnosis.
Diagnosing Multiple Sclerosis Using Breath Biomarkers and GC-MS.
As a...
- 2 Replies
- 460 Views
-
Last post by frodo
Tue Dec 10, 2019 2:11 am
-
-
MS clinical types are obsolete
by
frodo » Sun Dec 08, 2019 4:57 am
Since Charcot times, neurologist classify the MS types by its clinical evolution. This is so deeply stablished that even when NMO was considered a...
- 0 Replies
- 544 Views
-
Last post by frodo
Sun Dec 08, 2019 4:57 am
-
-
MS linked to lipids dysregulation
Replies: 1
by
frodo » Mon Dec 02, 2019 11:26 am
First post
Before reading the paper, it is interesting also this:
Specialized pro-resolving lipid mediators are differentially altered in peripheral blood...
Last post
This caught my interest as there are a couple of proresolving mediator supplements available on the market. The assumption is they will cross BBB as...
- 1 Replies
- 487 Views
-
Last post by Anonymoose
Wed Dec 04, 2019 6:10 am
-
-
MRZR+ MS cases are different from others
Replies: 1
by
frodo » Mon Aug 26, 2019 5:08 am
First post
MRZR is a reaction about several viruses highly specific for MS, but little sensitive. This means that if you have MRZR is nearly sure that you have...
Last post
Rheumatic diseases (lupus like diseases) and 60% of MS cases show antinuclear antibodies (ANA), leading to diagnosis confusion. MRZR can separate...
- 1 Replies
- 629 Views
-
Last post by frodo
Fri Nov 29, 2019 5:59 am
-
-
MS defined as a CD8+ disease
Replies: 1
by
frodo » Thu Oct 17, 2019 3:01 am
First post
This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing...
Last post
Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis
Significance
Multiple sclerosis (MS) is an inflammatory...
- 1 Replies
- 786 Views
-
Last post by frodo
Sun Nov 24, 2019 6:03 am
-
-
MS signature in plasma and CSF
Replies: 1
by
frodo » Thu Oct 31, 2019 11:53 am
First post
Multiple sclerosis has a distinct lipid signature in plasma and cerebrospinal fluid
ABSTRACT
The diagnosis of multiple sclerosis (MS) has...
Last post
2019 Oct 14
Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
HDL-cholesterol elevation associated with...
- 1 Replies
- 680 Views
-
Last post by Petr75
Thu Nov 21, 2019 10:29 pm
-
-
Prodromal MS: Biomarkers
Replies: 2
by
frodo » Tue Aug 07, 2018 6:57 am
First post
Prodrome is the stage of a disease in which there are no noticeable symptoms, but nevertheless the disease is present. In MS this means that is a...
Last post
Normalized cerebellar white matter and gray matter volume were significantly decreased in RIS compared to healthy controls.
Cerebellar volume loss...
- 2 Replies
- 1277 Views
-
Last post by frodo
Thu Nov 07, 2019 7:16 am
-
-
- 0 Replies
- 474 Views
-
Last post by frodo
Thu Nov 07, 2019 5:44 am
-
-
An underlying process causes abnormalities in veins together with MS
Replies: 2
by
frodo » Thu May 09, 2019 1:41 am
First post
This paper points to the existence of an underlying process that causes the known MS lesions and, at the same time, some venous problems:
The...
Last post
Central vein sign: More about vascular problems and MS. 100% sensitivity.
Single Test to ARrive at Multiple Sclerosis (STAR-MS) diagnosis: A...
- 2 Replies
- 875 Views
-
Last post by frodo
Mon Nov 04, 2019 7:26 am
-
-
- 0 Replies
- 973 Views
-
Last post by frodo
Thu Oct 24, 2019 8:03 am
-
-
- 1 Replies
- 658 Views
-
Last post by Petr75
Mon Oct 21, 2019 10:41 am
-
-
MRS of the brain
Replies: 1
by
frodo » Thu Oct 10, 2019 6:52 am
First post
MRS (Magnetic Resonance Spectroscopy) allows to see the chemical composition of the brain.
Magnetic resonance spectroscopy (MRS) is a non-invasive...
Last post
Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a
Background...
- 1 Replies
- 866 Views
-
Last post by frodo
Sun Oct 20, 2019 9:13 am
-
-
- 0 Replies
- 718 Views
-
Last post by frodo
Tue Oct 15, 2019 6:28 am
-
-
Large Noncoding RNA in blood
Replies: 5
by
frodo » Wed Oct 04, 2017 12:30 pm
First post
Expression Analysis of Long Non-coding RNAs in the Blood of Multiple Sclerosis Patients.
Abstract
Multiple sclerosis (MS) is a chronic...
Last post
2019 Aug 6
Department of Cardiovascular Medicine, The Second Hospital Affiliated to Jilin University, Changchun, China
Exosomal long noncoding RNAs...
- 5 Replies
- 1597 Views
-
Last post by Petr75
Sat Oct 12, 2019 11:16 pm
-
-
- 0 Replies
- 709 Views
-
Last post by frodo
Wed Oct 09, 2019 11:40 am
-
-
MS induced by mistake
by
frodo » Wed Oct 09, 2019 11:35 am
An unfortunate accident has shown something that could replace EAE.
Multiple sclerosis associated with pembrolizumab in a patient with non-small...
- 0 Replies
- 705 Views
-
Last post by frodo
Wed Oct 09, 2019 11:35 am
-
-
EBV-activated CD8+ Tcells infiltrate the MS brain
Replies: 1
by
frodo » Tue Oct 08, 2019 2:26 am
First post
More clues pointing to EBV as the culprit. And more evidence that EAE (a CD4+ disease) and MS have nothing to do.
EBV-activated CD8+ Tcells...
Last post
And maybe the mechanism by which the anti-EBV Tcells cause inflammation is because they cross-react with myelin MBP:
Myelin-specific CD8 T cells...
- 1 Replies
- 590 Views
-
Last post by frodo
Tue Oct 08, 2019 2:31 am
-
-
- 0 Replies
- 832 Views
-
Last post by frodo
Tue Oct 01, 2019 4:17 am
-
-
Myelocortical MS (MCMS)
Replies: 6
by
frodo » Thu Aug 23, 2018 5:03 am
First post
Researchers discover new subtype of multiple sclerosis (The Lancet)
Cleveland Clinic researchers have discovered a new subtype of multiple...
Last post
The cortical pathology is associated to a specific CSF profile:
Inflammatory intrathecal profiles and cortical damage in multiple sclerosis...
- 6 Replies
- 1663 Views
-
Last post by frodo
Tue Oct 01, 2019 4:07 am
-
-
- 0 Replies
- 740 Views
-
Last post by frodo
Tue Oct 01, 2019 3:34 am
-
-
Review on biomarkers 2019
by
frodo » Tue Sep 24, 2019 1:23 am
Available on Barts MS research page:
there is a review covering the following 6 topics in biomarkers, presented at ECTRIMS 2019:
-serum...
- 0 Replies
- 679 Views
-
Last post by frodo
Tue Sep 24, 2019 1:23 am
-
-
- 0 Replies
- 766 Views
-
Last post by frodo
Mon Sep 16, 2019 7:05 am
-
-
- 0 Replies
- 401 Views
-
Last post by frodo
Sun Sep 15, 2019 11:20 am
-
-
- 0 Replies
- 530 Views
-
Last post by frodo
Thu Sep 05, 2019 6:39 am
-
-
closer to an urine test
Replies: 2
by
frodo » Mon Sep 02, 2019 11:45 pm
First post
Abstract
BACKGROUND: Systemic inflammation is a marker of ill health and has prognostic implications in multiple health settings. Urinary neopterin...
Last post
Maybe it is related. It would be nice to have an update, but the problem with this kind of papers is that they are easily forgotten
- 2 Replies
- 336 Views
-
Last post by frodo
Thu Sep 05, 2019 6:38 am
-
-
Temelimab works. HERVs clearly implicated.
Replies: 4
by
frodo » Mon May 20, 2019 11:38 am
First post
Efficacy and Safety of Temelimab, an Antibody Antagonist of the Human Endogenous Retrovirus Type-W env Protein, in Participants with Relapsing...
Last post
And here a new review about the role of HERVs in microglia activation, following Kremer's paper from last May.
This researchers confirm again the...
- 4 Replies
- 659 Views
-
Last post by frodo
Sun Sep 01, 2019 11:14 am
-
-
Ashton Embry: Multiple Factors in MS Etiology
Replies: 1
by
NHE » Mon Aug 26, 2019 2:56 pm
First post
Ashton Embry published a review paper in 2004 discussing multiple factors in MS etiology. Note, this paper predates CCSVI so it does not address...
Last post
I agree about the multifactiorial source of MS, but in the sense that probably there exists different kinds of MS, each one of them with a different...
- 1 Replies
- 355 Views
-
Last post by frodo
Tue Aug 27, 2019 4:13 am
-
-
Around 13% of MS cases are of genetic origin. 12 pathogenic variants.
Replies: 1
by
frodo » Tue Aug 13, 2019 7:38 am
First post
Of people diagnosed with MS, only 13% are believed to have a genetic form of the disease, but those presenting the mutations identified in this new...
Last post
Some other reports of heterogeneity:
HLA-DRB1 differences in allelic distribution between familial and sporadic multiple sclerosis in a Hellenic...
- 1 Replies
- 538 Views
-
Last post by frodo
Fri Aug 16, 2019 10:15 am
-
-
PPMS and SPMS may be different
by
frodo » Sun Aug 11, 2019 3:53 am
Mitochondrial functionality and metabolism in T cells from progressive multiple sclerosis patients
Abstract
Patients with primary progressive...
- 0 Replies
- 735 Views
-
Last post by frodo
Sun Aug 11, 2019 3:53 am
-
-
- 0 Replies
- 394 Views
-
Last post by frodo
Sat Aug 10, 2019 10:13 am
-
-
Lipid profile of cerebrospinal fluid
by
frodo » Sat Aug 10, 2019 9:28 am
Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis
Discussion
MS is a chronic disease which is...
- 0 Replies
- 404 Views
-
Last post by frodo
Sat Aug 10, 2019 9:28 am
-
-
- 0 Replies
- 489 Views
-
Last post by frodo
Wed Jul 31, 2019 11:36 pm
-
-
Weird biomarker
Replies: 2
by
frodo » Mon Jul 29, 2019 6:34 am
First post
Though I don't understand fully what they say, it seems that they have created a molecule with a fluorescent substrate surrounded by MBP proteins....
Last post
I agree. The T-cell model is dead. At least the CD4+ classic model.
- 2 Replies
- 461 Views
-
Last post by frodo
Wed Jul 31, 2019 11:08 pm
-
-
CSF from MS patients damage neurons in-vitro
Replies: 1
by
frodo » Mon Jul 22, 2019 12:56 am
First post
A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis
Abstract
Multiple sclerosis is an autoimmune demyelinating...
Last post
Comments on the previous paper. A new paper in “Brain” identifies molecular mechanisms causing neuronal damage in multiple sclerosis patients with...
- 1 Replies
- 598 Views
-
Last post by frodo
Mon Jul 29, 2019 8:24 am
-
-
- 0 Replies
- 352 Views
-
Last post by frodo
Mon Jul 29, 2019 8:09 am
-
-
- 0 Replies
- 383 Views
-
Last post by frodo
Mon Jul 29, 2019 5:06 am
-
-
- 0 Replies
- 401 Views
-
Last post by frodo
Sat Jul 13, 2019 1:04 am
-
-
- 0 Replies
- 543 Views
-
Last post by frodo
Thu Jun 27, 2019 12:58 am
Forum permissions
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
