MS Etiology and Pathogenesis

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Biomarkers of the underlying process

Last post by frodo « Sun Dec 09, 2018 11:07 am

by frodo » Sun Dec 09, 2018 11:07 am

Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity

HIGHLIGHTS

• Microglial/myeloid...

0 Replies

792 Views

Last post by frodo
Sun Dec 09, 2018 11:07 am
Blood indicators of clinical status and plasma exchange prog

Last post by frodo « Sat Dec 08, 2018 12:53 am

by frodo » Sat Dec 08, 2018 12:53 am

Blood plasma thermal behavior and protein oxidation as indicators of multiple sclerosis clinical status and plasma exchange therapy progression...

0 Replies

792 Views

Last post by frodo
Sat Dec 08, 2018 12:53 am
Anyone thought to have MS should be tested for biotinidase d

Last post by frodo « Sat Dec 01, 2018 12:16 am

by frodo » Sat Dec 01, 2018 12:16 am

ALL INDIVIDUALS THOUGHT TO HAVE MULIPLE SCLEROSIS SHOULD BE TESTED FOR BIOTINIDASE DEFICIENCY

Highlights

• Adults with biotinidase deficiency...

0 Replies

924 Views

Last post by frodo
Sat Dec 01, 2018 12:16 am
FINALLY AN AUTOANTIGEN - And gut microbioma connections.

Last post by frodo « Sun Oct 21, 2018 3:01 am
Replies: 1
by frodo » Thu Oct 18, 2018 3:06 am

First post

Before I was completely sure about MS not being autoimmune. Well, maybe I was wrong.

Let's see if this report is confirmed.

GDP-l-fucose...

Last post

More news about this. A clinical trial is coming up.

It seems that the autoimmune system can be re-educated. The same team in Zurich is trying to...

1 Replies

690 Views

Last post by frodo
Sun Oct 21, 2018 3:01 am
what is an HLA DRB3 positive patient?

Last post by frodo « Fri Oct 19, 2018 11:17 am

by frodo » Fri Oct 19, 2018 11:17 am

Regarding my last post about an antigen found, it only appears in a group of patients that they call DRB3 positive. I have taken a look at what means...

0 Replies

697 Views

Last post by frodo
Fri Oct 19, 2018 11:17 am
National MS society web: The word "autoimmune"dissapears.

Last post by jimmylegs « Wed Oct 17, 2018 12:43 pm
Replies: 5
by frodo » Mon Oct 08, 2018 9:31 am

First post

After several years saying MS is an autoimmune disease that ... now they begin like this:

Multiple sclerosis (MS) is an unpredictable, often...

Last post

related

Taking into account the results of B‐cell‐depleting drugs, the production of autoantibodies as the driving force in MS pathology has...

5 Replies

699 Views

Last post by jimmylegs
Wed Oct 17, 2018 12:43 pm
Diagnosis based in serum lipids. Focus on lipid metabolism?

Last post by frodo « Sun Oct 14, 2018 12:22 pm

by frodo » Sun Oct 14, 2018 12:22 pm

Excerpts:

Based on increasing evidence suggesting that MS pathology involves alterations in bioactive lipid metabolism , the present analysis was...

0 Replies

579 Views

Last post by frodo
Sun Oct 14, 2018 12:22 pm
2018 correspondence - MS Genetics: Overview & New Directions

Last post by jimmylegs « Sun Sep 30, 2018 4:18 am

by jimmylegs » Sun Sep 30, 2018 4:18 am

Genetics of Multiple Sclerosis: An Overview and New Directions

Abstract
The contribution of genetic inheritance in multiple sclerosis was...

0 Replies

530 Views

Last post by jimmylegs
Sun Sep 30, 2018 4:18 am
Interleukin 36 in MS

Last post by frodo « Sat Sep 29, 2018 2:46 am

by frodo » Sat Sep 29, 2018 2:46 am

Interleukin 36 is a cytokine normally associated with psoriasis. It seems that also appears disregulated in MS. It can be meassured in blood serum...

0 Replies

495 Views

Last post by frodo
Sat Sep 29, 2018 2:46 am
Oligoclonal G bands. Up to 99.5% specificity

Last post by frodo « Wed Sep 26, 2018 5:05 am

by frodo » Wed Sep 26, 2018 5:05 am

Early Differential Diagnosis of Multiple Sclerosis Using a New Oligoclonal Band Test

Results

Intrathecal IgG synthesis was found in 127...

0 Replies

588 Views

Last post by frodo
Wed Sep 26, 2018 5:05 am
new diagnostic protocol proposed

Last post by frodo « Wed Sep 26, 2018 5:02 am
Replies: 2
by frodo » Tue Sep 25, 2018 8:31 am

First post

One of the worst problems of MS is the misdiagnosis. Given the strong side effects of some drugs neurologist wanto to be sure and delay the diagnosis...

Last post

A few days ago you posted info on a blood test for diagnosing MS. Not sure is this new diagnostic protocol is necessary if the accuracy of the blood...

2 Replies

668 Views

Last post by frodo
Wed Sep 26, 2018 5:02 am
meningeal inflammation

Last post by frodo « Tue Sep 25, 2018 9:23 am

by frodo » Tue Sep 25, 2018 9:23 am

Abstract

The presence of leptomeningeal inflammation (LMI) in MS was first identified in 2004 and multiple subsequent studies have confirmed the...

0 Replies

508 Views

Last post by frodo
Tue Sep 25, 2018 9:23 am
2018 study: optic nerves and dissemination in space

Last post by jimmylegs « Sun Sep 23, 2018 12:24 pm

by jimmylegs » Sun Sep 23, 2018 12:24 pm

well, my optic nerves were pristine at dx - not so much 12 yrs later (lefty seems to have taken a hit)

Inclusion of optic nerve involvement in...

0 Replies

495 Views

Last post by jimmylegs
Sun Sep 23, 2018 12:24 pm
Axonal Damage without T2-Lesions: Primary neurodegeneration?

Last post by frodo « Sat Sep 22, 2018 9:24 am

by frodo » Sat Sep 22, 2018 9:24 am

Evidence of Axonal Damage in Cerebellar Peduncles (CP) without T2-Lesions in Multiple Sclerosis

Highlights

• Cerebellar DTI abnormalities...

0 Replies

504 Views

Last post by frodo
Sat Sep 22, 2018 9:24 am
2011 proposal: environment is MS' main cause; genetics minor

Last post by Petr75 « Wed Sep 19, 2018 10:05 am
Replies: 4
by jimmylegs » Thu Aug 30, 2018 10:32 am

First post

The major cause of multiple sclerosis is environmental: genetics has a minor role - Yes (2011)

Proposal
It is clear that multiple sclerosis (MS)...

Last post

Good article.

4 Replies

816 Views

Last post by Petr75
Wed Sep 19, 2018 10:05 am
Familial MS could be different from normal MS

Last post by frodo « Fri Aug 24, 2018 12:06 pm
Replies: 1
by frodo » Fri Aug 17, 2018 2:17 am

First post

Familial MS could be different from normal (sporadic) MS. They could be different diseases, needing different therapies, just like MS and NMO....

Last post

Notice that it could be related to this:

A mutation in a nuclear receptor (NR1H3) gene was detected in a familial, progressive form of multiple...

1 Replies

684 Views

Last post by frodo
Fri Aug 24, 2018 12:06 pm
miRNAs: Identification of MS-specific serum miRNAs

Last post by frodo « Fri Aug 24, 2018 12:00 pm

by frodo » Fri Aug 24, 2018 12:00 pm

Identification of MS-specific serum miRNAs in an international multicenter study

Abstract

Objective To identify circulating microRNAs (miRNAs)...

0 Replies

550 Views

Last post by frodo
Fri Aug 24, 2018 12:00 pm
Multiple Sclerosis: an "EMotional" issue. The microbian code

Last post by ElliotB « Fri Aug 24, 2018 11:02 am
Replies: 10
by hmacoli » Thu Jul 12, 2018 10:32 am

First post

This is an excerpt from my last page posted in my blog about MS as an emotional issue (not only but above)…that I would like to share with you.

It...

Last post

Thanks for the additional info. I did a quick check and the machines are available here but are very, very expensive.

I am having surprisingly good...

10 Replies

1146 Views

Last post by ElliotB
Fri Aug 24, 2018 11:02 am
Vitamin D levels in MS impact Epstein-Barr viral load

Last post by jimmylegs « Thu Aug 23, 2018 8:32 am
Replies: 1
by frodo » Thu Aug 23, 2018 7:20 am

First post

Vitamin D levels in MS impact Epstein-Barr viral load

A study, published at ECTRIMS 2017, has revealed that serum vitamin D levels could be...

Last post

lab-supported anecdote - i've used nutritional boot camp to eradicate another's chronic EBV viral load.
took a connection of mine from being in line...

1 Replies

635 Views

Last post by jimmylegs
Thu Aug 23, 2018 8:32 am
Barts blog: EBV and B-cells again

Last post by frodo « Tue Aug 21, 2018 3:53 am

by frodo » Tue Aug 21, 2018 3:53 am

B cell Cytokines in MS brain, may support B cell follicles.

Excerpts:

Although B cell depletion is an effective therapy of multiple sclerosis...

0 Replies

599 Views

Last post by frodo
Tue Aug 21, 2018 3:53 am
For researchers: Red flags in diagnosis

Last post by frodo « Tue Aug 21, 2018 3:47 am

by frodo » Tue Aug 21, 2018 3:47 am

Some reports point to a 10% misdiagnosis, specially due to the appearance of lesions in MRI. It seems that non-demyelinating lesions are normal and...

0 Replies

601 Views

Last post by frodo
Tue Aug 21, 2018 3:47 am
Barts Blog: Does degradation of brain fats cause MS?

Last post by frodo « Tue Aug 21, 2018 3:36 am

by frodo » Tue Aug 21, 2018 3:36 am

Does degradation of brain fats cause MS?

This is to let you know about a research project based on a novel idea of how MS develops. I am a...

0 Replies

530 Views

Last post by frodo
Tue Aug 21, 2018 3:36 am
EBV again. Genetic evidence of its involvement

Last post by frodo « Fri Aug 17, 2018 1:44 am

by frodo » Fri Aug 17, 2018 1:44 am

Genetic evidence that the latency III stage of Epstein-Barr Virus infection is a therapeutic target for Multiple Sclerosis

Abstract

Genome wide...

0 Replies

549 Views

Last post by frodo
Fri Aug 17, 2018 1:44 am
Biomarkers: proteomic profiling of human saliva

Last post by frodo « Wed Aug 08, 2018 2:57 pm

by frodo » Wed Aug 08, 2018 2:57 pm

Top-down proteomic profiling of human saliva in multiple sclerosis patients.

Abstract

Multiple sclerosis is a chronic disease of the central...

0 Replies

651 Views

Last post by frodo
Wed Aug 08, 2018 2:57 pm
review about neurofilaments

Last post by frodo « Tue Aug 07, 2018 3:10 pm

by frodo » Tue Aug 07, 2018 3:10 pm

Editorial of the Multiple Sclerosis Journal

Are neurofilaments valuable biomarkers for long-term disease prognostication in MS?

Neuroaxonal...

0 Replies

610 Views

Last post by frodo
Tue Aug 07, 2018 3:10 pm
DNA methiylation signatures in MS twins

Last post by frodo « Tue Aug 07, 2018 6:57 am

by frodo » Tue Aug 07, 2018 6:57 am

DNA methylation signatures of a large cohort monozygotic twins clinically discordant for multiple sclerosis

Abstract

Multiple sclerosis (MS) is...

0 Replies

624 Views

Last post by frodo
Tue Aug 07, 2018 6:57 am
Neurofilaments in CSF predict behaviour of MS in ten years

Last post by frodo « Tue Aug 07, 2018 6:53 am

by frodo » Tue Aug 07, 2018 6:53 am

This could save some people with mild MS from being treated

Neurofilaments and 10-year follow-up in multiple sclerosis

Background:

The role...

0 Replies

589 Views

Last post by frodo
Tue Aug 07, 2018 6:53 am
Microglia is just another sympthom, not the cause

Last post by frodo « Sun Jul 29, 2018 10:47 pm

by frodo » Sun Jul 29, 2018 10:47 pm

It seems that microglia activation could be a symptom of axonal damage, and not the ultimate cause nor related to pre-active lesions. Microglia...

0 Replies

683 Views

Last post by frodo
Sun Jul 29, 2018 10:47 pm
Can we tame microglia?

Last post by frodo « Sat Jul 28, 2018 10:53 am

by frodo » Sat Jul 28, 2018 10:53 am

It seems so.

Microglia P2X4 receptors as pharmacological targets for demyelinating diseases

Multiple sclerosis (MS) is a chronic inflammatory...

0 Replies

659 Views

Last post by frodo
Sat Jul 28, 2018 10:53 am
Epstein Barr virus again

Last post by frodo « Sat Jul 28, 2018 9:07 am
Replies: 1
by frodo » Mon Jan 22, 2018 3:17 am

First post

Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple...

Last post

This article also points out a connection between the four patterns theory and the EBV brain infection.

It is also known that the CNS immune...

1 Replies

1087 Views

Last post by frodo
Sat Jul 28, 2018 9:07 am
IgM+ patients should not be treated with interferon

Last post by frodo « Thu Jul 26, 2018 11:14 pm

by frodo » Thu Jul 26, 2018 11:14 pm

MS patients present oligoclonal bands (OCB) in their cerebrospinal fluid (CSF). Among the oligoclonal bands there could be some related to...

0 Replies

668 Views

Last post by frodo
Thu Jul 26, 2018 11:14 pm
Dysregulated EBV infection in MS. Old but relevant.

Last post by jimmylegs « Wed Jul 25, 2018 6:46 am
Replies: 2
by frodo » Sun Jul 22, 2018 6:18 pm

First post

They know since 2007 that EBV is to blame. What are they waiting for to try antiviral therapies??

Dysregulated Epstein-Barr virus infection in the...

Last post

my 2c: correlation vs causation. i have limited but lab documented evidence of reducing both EBV viral load and food sensitivities (n=1, but not me)...

2 Replies

653 Views

Last post by jimmylegs
Wed Jul 25, 2018 6:46 am
review of PET in several diseases, including MS

Last post by frodo « Mon Jul 23, 2018 10:59 am

by frodo » Mon Jul 23, 2018 10:59 am

Drugs evaluated in these studies include specific therapeutics which have already granted FDA licensure like interferon beta, glatiramer acetate, and...

0 Replies

644 Views

Last post by frodo
Mon Jul 23, 2018 10:59 am
Lesions evolution under PET

Last post by frodo « Mon Jul 23, 2018 10:50 am

by frodo » Mon Jul 23, 2018 10:50 am

PET (Positron imaging technology) is a imaging method able to show the molecular structure of a lesion.

Several radioligands, compounds that work as...

0 Replies

638 Views

Last post by frodo
Mon Jul 23, 2018 10:50 am
OCB negative MS - immunogenetically distinct

Last post by frodo « Sun Jul 22, 2018 6:22 pm

by frodo » Sun Jul 22, 2018 6:22 pm

Multiple sclerosis with and without CSF bands: Clinically indistinguishable but immunogenetically distinct

Abstract

We sought to determine...

0 Replies

675 Views

Last post by frodo
Sun Jul 22, 2018 6:22 pm
Biomarkers: Response to Glatiramer Acetate predictable

Last post by frodo « Sun Jul 22, 2018 10:26 am

by frodo » Sun Jul 22, 2018 10:26 am

It seems that a biomarker in blood predicts response to GA

Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with...

0 Replies

646 Views

Last post by frodo
Sun Jul 22, 2018 10:26 am
Personalized medicine: Selective therapy

Last post by frodo « Tue Jul 10, 2018 2:06 am

by frodo » Tue Jul 10, 2018 2:06 am

Here there is a freely available review about the state-of-the-art as it was 2 years ago.

Personalised medicine for multiple sclerosis care...

0 Replies

707 Views

Last post by frodo
Tue Jul 10, 2018 2:06 am
Personalized medicine in multiple sclerosis

Last post by frodo « Thu Jul 05, 2018 1:12 am

by frodo » Thu Jul 05, 2018 1:12 am

Personalized medicine here means to divide the patients in subgroups so that the response to medication is optimal.

It seems that some hospitals...

0 Replies

788 Views

Last post by frodo
Thu Jul 05, 2018 1:12 am
Progressive MS: Natural evolution in PPMS and SPMS

Last post by frodo « Wed Jul 04, 2018 4:21 am

by frodo » Wed Jul 04, 2018 4:21 am

Pathology and Pathogenesis of Progressive Multiple Sclerosis: Concepts and Controversies

Summary

Multiple sclerosis changes not only its...

0 Replies

779 Views

Last post by frodo
Wed Jul 04, 2018 4:21 am
Heterogeneity: CSF profile predicts response to interferons

Last post by frodo « Wed Jul 04, 2018 3:58 am

by frodo » Wed Jul 04, 2018 3:58 am

In a small study patients were clustered into 6 distinct subsets by baseline cytokine profiles of CSF.

Two subsets were associated with patients...

0 Replies

683 Views

Last post by frodo
Wed Jul 04, 2018 3:58 am
Barts blog: EBV in Brain

Last post by frodo « Tue Jul 03, 2018 2:29 am

by frodo » Tue Jul 03, 2018 2:29 am

EBV in Brain

Source:

The best evidence to date does suggest that EBV is present in both MS and control brains, but is more common in pwMS (90% vs...

0 Replies

734 Views

Last post by frodo
Tue Jul 03, 2018 2:29 am
Immunoglobulins and B-cells

Last post by frodo « Mon Jul 02, 2018 2:13 am

by frodo » Mon Jul 02, 2018 2:13 am

It seems that B-cells are responsible for producing the oligoclonal Bands (OCB) that appear in MS. For some reason which I don't understand, the...

0 Replies

723 Views

Last post by frodo
Mon Jul 02, 2018 2:13 am
Evolution of the lesions during three years

Last post by ElliotB « Tue Jun 26, 2018 4:47 am
Replies: 1
by frodo » Mon Jun 25, 2018 11:48 pm

First post

This is a french study about how lesions evolve seeing by MRI. The article is in PDF and freely available.

Abstract : Obtaining information on...

Last post

This time lapse video spans a 12 month time frame of someone with RRMS. It is quite fascinating!
It is interesting that they (lesions) can grow,...

1 Replies

857 Views

Last post by ElliotB
Tue Jun 26, 2018 4:47 am
How B-cells produce MS

Last post by frodo « Tue Jun 26, 2018 3:10 am

by frodo » Tue Jun 26, 2018 3:10 am

For most of the authors is not an issue anymore if B-cells are the cause of MS. The question is how they produce MS. Here there is a fully available...

0 Replies

829 Views

Last post by frodo
Tue Jun 26, 2018 3:10 am
MS B-cells in vitro do weird things and CCSVI connection.

Last post by frodo « Tue Jun 26, 2018 12:31 am

by frodo » Tue Jun 26, 2018 12:31 am

This is an article that I am reading slowly, as I do not understand most of the things it says. But the summary is that MS B-cells do weird things....

0 Replies

769 Views

Last post by frodo
Tue Jun 26, 2018 12:31 am
OCB-negative MS

Last post by frodo « Tue Jun 19, 2018 5:49 am
Replies: 5
by frodo » Tue Jun 19, 2018 5:22 am

First post

OCB (oligoclonal bands) negative MS is rare, around 10% in patients of european ancestry, but higher outside this population. Notice that Pattern III...

Last post

A study of oligoclonal band negative multiple sclerosis.

Abstract

OBJECTIVES --To determine whether oligoclonal band (OCB) negative multiple...

5 Replies

1063 Views

Last post by frodo
Tue Jun 19, 2018 5:49 am
Demyelinating disorders. Cousins of MS updated.

Last post by frodo « Tue Jun 19, 2018 5:05 am
Replies: 1
by frodo » Tue Jun 19, 2018 5:03 am

First post

An interesting diagram speaking about Anti-MOG associated encephalomyelitis. Some MS cases could be anti-MOG in reality. Get informed.

Clinical...

Last post

Update: Intermediate cases between MS and NMO

B cell depleting therapy for multiple sclerosis overlapping with neuromyelitis optica spectrum...

1 Replies

804 Views

Last post by frodo
Tue Jun 19, 2018 5:05 am
MS as a neuro-degenerative disorder

Last post by frodo « Tue Jun 19, 2018 4:53 am

by frodo » Tue Jun 19, 2018 4:53 am

Development of biomarkers for multiple sclerosis as a neurodegenerative disorder

Abstract

Multiple sclerosis (MS) is the most common...

0 Replies

722 Views

Last post by frodo
Tue Jun 19, 2018 4:53 am
MRZ Reaction: Helps to distinguish MS from its mimics

Last post by frodo « Tue Jun 19, 2018 1:01 am

by frodo » Tue Jun 19, 2018 1:01 am

The mrz reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis

Abstract

Background...

0 Replies

706 Views

Last post by frodo
Tue Jun 19, 2018 1:01 am
simvastatin mechanism is independent from cholesterol

Last post by frodo « Mon Jun 18, 2018 4:33 am

by frodo » Mon Jun 18, 2018 4:33 am

Whatever simvastatin does in MS is independent from its cholesterol function

Abstract

The analysis of clinical trials is limited to...

0 Replies

628 Views

Last post by frodo
Mon Jun 18, 2018 4:33 am

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