MS Etiology and Pathogenesis

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Last post

Biomarker in the skin. Fibroblasts

Last post by frodo « Tue Jul 14, 2020 7:41 am

by frodo » Tue Jul 14, 2020 7:41 am

Information about fibroblasts in wikipedia:

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple...

0 Replies

191 Views

Last post by frodo
Tue Jul 14, 2020 7:41 am
The picture of demyelinating diseases gets more complicated

Last post by frodo « Mon Jul 13, 2020 8:50 am
Replies: 1
by frodo » Wed Feb 06, 2019 2:38 am

First post

This is the current picture as far as the current knowledge suggest. The picture is more complex than previously thought, even if anti-neurofascin...

Last post

Immunoadsorption and Plasma Exchange in Seropositive and Seronegative Immune-Mediated Neuropathies

Abstract

The inflammatory neuropathies are...

1 Replies

702 Views

Last post by frodo
Mon Jul 13, 2020 8:50 am
Biomarkers: MRZ reaction distinguish MS and other disorders

Last post by frodo « Mon Jul 13, 2020 8:26 am
Replies: 1
by frodo » Mon Feb 05, 2018 9:28 am

First post

The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.

Some rheumatologic...

Last post

Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

Abstract

Antibody indices to MRZ are of...

1 Replies

900 Views

Last post by frodo
Mon Jul 13, 2020 8:26 am
IMPORTANT: Dysfunctional RNA‐binding proteins in MS

Last post by frodo « Mon Jul 13, 2020 8:21 am

by frodo » Mon Jul 13, 2020 8:21 am

As far as I know this is the first time that something like this has been reported.

Neuronal RNA‐binding protein dysfunction in multiple sclerosis...

0 Replies

161 Views

Last post by frodo
Mon Jul 13, 2020 8:21 am
Siponimod reduces progression with or without relapses

Last post by frodo « Mon Jul 13, 2020 8:12 am

by frodo » Mon Jul 13, 2020 8:12 am

Siponimod Affects Disability Progression in Patients with Secondary Progressive Multiple Sclerosis Independent of Relapse Activity

Background :...

0 Replies

218 Views

Last post by frodo
Mon Jul 13, 2020 8:12 am
Highly active MS and specific treatment

Last post by frodo « Tue Jun 30, 2020 12:37 am

by frodo » Tue Jun 30, 2020 12:37 am

It is not an official but regulatory agencies considered the highly active MS (HAMS) separated from the rest in their approval processes for...

0 Replies

208 Views

Last post by frodo
Tue Jun 30, 2020 12:37 am
Microglia are the culprits for slowly expanding lesions

Last post by frodo « Mon Jun 29, 2020 12:17 am

by frodo » Mon Jun 29, 2020 12:17 am

Slowly expanding lesions are suspected to be the cause of the MS progressive phase. Microglia and macrophages are cells that look similar and were...

0 Replies

130 Views

Last post by frodo
Mon Jun 29, 2020 12:17 am
biomarkers review 2020 and more fingers pointing to EBV

Last post by frodo « Mon Jun 29, 2020 12:11 am

by frodo » Mon Jun 29, 2020 12:11 am

Molecular Biomarkers in the Cerebrospinal Fluid in Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the spinal...

0 Replies

146 Views

Last post by frodo
Mon Jun 29, 2020 12:11 am
Three new genetic variants of MS

Last post by frodo « Thu Jun 25, 2020 1:33 am

by frodo » Thu Jun 25, 2020 1:33 am

Neurological phenotypes in patients with NLRP3-, MEFV-, and TNFRSF1A low-penetrance variants

Background

Neurological manifestations and the...

0 Replies

140 Views

Last post by frodo
Thu Jun 25, 2020 1:33 am
Biotin treatment can turn PPMS into relapsing

Last post by frodo « Tue Jun 23, 2020 8:46 am

by frodo » Tue Jun 23, 2020 8:46 am

There are contradicting reports on this topic. See for instance

Relapses During High-Dose Biotin Treatment in Progressive Multiple Sclerosis: a...

0 Replies

179 Views

Last post by frodo
Tue Jun 23, 2020 8:46 am
Automatic segmentation of different lesion types

Last post by frodo « Tue Jun 23, 2020 8:44 am

by frodo » Tue Jun 23, 2020 8:44 am

Identification of Multiple Sclerosis lesion subtypes and their quantitative assessments with EDSS using neuroimaging

Abstract

It would be...

0 Replies

104 Views

Last post by frodo
Tue Jun 23, 2020 8:44 am
STIR Imaging of Intracranial Disease

Last post by frodo « Tue Jun 23, 2020 8:34 am

by frodo » Tue Jun 23, 2020 8:34 am

Postcontrast STIR imaging offers additional information, not obtained with other sequences:

Postcontrast STIR Imaging of Intracranial Disease...

0 Replies

111 Views

Last post by frodo
Tue Jun 23, 2020 8:34 am
prognosis based in a blood test

Last post by frodo « Tue Jun 16, 2020 2:33 am

by frodo » Tue Jun 16, 2020 2:33 am

Clues to prognosis in multiple sclerosis found in the blood

Neurofilament light (NfL) and microRNAs (miRNAs) can help to predict the course that...

0 Replies

301 Views

Last post by frodo
Tue Jun 16, 2020 2:33 am
The division of MS in "types" was made up just to approve interferons

Last post by frodo « Tue Jun 16, 2020 2:26 am
Replies: 1
by frodo » Tue Jun 16, 2020 2:21 am

First post

Multiple sclerosis – a review

There has been a reduction in the proportion of people with PPMS. This is probably related to the fact that there...

Last post

New type under research. They are trying to achieve a standard definition for agressive MS. Maybe this will be more interesting than the previous...

1 Replies

186 Views

Last post by frodo
Tue Jun 16, 2020 2:26 am
Hint for a new NMO variant confused into the MS spectrum

Last post by frodo « Thu Jun 11, 2020 5:46 am

by frodo » Thu Jun 11, 2020 5:46 am

After classifying atypical cases in four groups, the classical MS, anti-AQP4 and anti-MOG groups appear, but a fourth group unclassifiable also...

0 Replies

192 Views

Last post by frodo
Thu Jun 11, 2020 5:46 am
biomarker for response to interferon beta-1b

Last post by frodo « Tue Jun 09, 2020 2:38 am

by frodo » Tue Jun 09, 2020 2:38 am

A long-term follow-up study on biochemical and clinical biomarkers of response to interferon beta-1b treatment in relapsing-remitting multiple...

0 Replies

215 Views

Last post by frodo
Tue Jun 09, 2020 2:38 am
CCSVI ten years later

Last post by frodo « Thu Jun 04, 2020 12:39 am

by frodo » Thu Jun 04, 2020 12:39 am

Chronic cerebrospinal venous insufficiency, ten years after. New headlights on a venous disease that enriched the vascular world

Pdf available...

0 Replies

322 Views

Last post by frodo
Thu Jun 04, 2020 12:39 am
Four patterns of oligoclonal bands

Last post by frodo « Sat May 30, 2020 12:51 am

by frodo » Sat May 30, 2020 12:51 am

Kappa Free Light Chains and IgG Combined in a Novel Algorithm for the Detection of Multiple Sclerosis

Abstract

Background :
It is well known...

0 Replies

216 Views

Last post by frodo
Sat May 30, 2020 12:51 am
Biomarker: Antibodies in the patients’ cerebrospinal fluid are attracted to some peptides

Last post by frodo « Fri May 29, 2020 6:28 am

by frodo » Fri May 29, 2020 6:28 am

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to early-stage multiple sclerosis

Highlights

•...

0 Replies

194 Views

Last post by frodo
Fri May 29, 2020 6:28 am
Molecular heterogeneity of pathogenic mechanisms

Last post by frodo « Tue May 26, 2020 4:30 am

by frodo » Tue May 26, 2020 4:30 am

This paper points to the existence of seven molecular groups in MS. They have used something called SOMAscan-based models to group patients by their...

0 Replies

208 Views

Last post by frodo
Tue May 26, 2020 4:30 am
IGM+ MS could be different from normal MS

Last post by frodo « Thu May 21, 2020 2:48 am
Replies: 2
by frodo » Thu Oct 31, 2019 11:35 am

First post

The oligoclonal bands in MS are IgG bands. There is a subset of patients with another immunoglobulin, IGM, that have a worse prognosis.

This paper...

Last post

Four bands of IGM is absolutely specific (100%) for MS. No healthy subject shows that, but is not very sensitive. 60% of the MS patients do not show...

2 Replies

854 Views

Last post by frodo
Thu May 21, 2020 2:48 am
Model of cortical demyelination with cytokines

Last post by frodo « Tue May 19, 2020 4:59 am

by frodo » Tue May 19, 2020 4:59 am

Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration...

0 Replies

231 Views

Last post by frodo
Tue May 19, 2020 4:59 am
Biomarkers. Response to Fingolimod can be predicted.

Last post by frodo « Tue May 19, 2020 4:52 am
Replies: 2
by frodo » Thu Apr 19, 2018 12:31 pm

First post

Predicting therapeutic response to fingolimod treatment in multiple sclerosis patients

Summary

Fingolimod, an orally active immunomodulatory...

Last post

New biomarker for fingolimod: CD56bright

Abstract

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system, which...

2 Replies

1354 Views

Last post by frodo
Tue May 19, 2020 4:52 am
PhD thesis about patterns and plasmapheresis

Last post by frodo « Tue May 19, 2020 4:48 am

by frodo » Tue May 19, 2020 4:48 am

Apheresis therapy in immunopathologically classified multiple sclerosis patients

Conclusion

Our results show that the response to apheresis...

0 Replies

179 Views

Last post by frodo
Tue May 19, 2020 4:48 am
PPMS in children is different than in adults.

Last post by frodo « Tue May 19, 2020 4:42 am

by frodo » Tue May 19, 2020 4:42 am

The good news is that children PPMS responds to RRMS medications.

Interestingly, in contrast to the continuing progression Abdel-Mannan et al.3...

0 Replies

209 Views

Last post by frodo
Tue May 19, 2020 4:42 am
Unknown circulating serum factors impair BBB integrity

Last post by frodo « Thu May 14, 2020 5:25 am

by frodo » Thu May 14, 2020 5:25 am

Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier

Conclusions

Our data suggest...

0 Replies

196 Views

Last post by frodo
Thu May 14, 2020 5:25 am
biomarker for early MS

Last post by frodo « Wed May 13, 2020 8:06 am

by frodo » Wed May 13, 2020 8:06 am

Nearly 100% of sensitivity (96.68%) !!

Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to...

0 Replies

208 Views

Last post by frodo
Wed May 13, 2020 8:06 am
Interleukin IL9 in SPMS

Last post by frodo « Mon May 11, 2020 3:44 am

by frodo » Mon May 11, 2020 3:44 am

Interleukin-9 regulates macrophage activation in the (secondary) progressive multiple sclerosis brain

Abstract

Background

Multiple sclerosis...

0 Replies

199 Views

Last post by frodo
Mon May 11, 2020 3:44 am
Biomarker for PPMS

Last post by frodo « Mon May 11, 2020 3:24 am

by frodo » Mon May 11, 2020 3:24 am

NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis

Increased activity of the NLRP3 inflammasome in immune cells...

0 Replies

224 Views

Last post by frodo
Mon May 11, 2020 3:24 am
plasmapheresis works for MS

Last post by frodo « Mon May 11, 2020 3:16 am

by frodo » Mon May 11, 2020 3:16 am

Double-blind, randomized controlled trial of therapeutic plasma exchanges vs sham exchanges in moderate-to-severe relapses of multiple sclerosis....

0 Replies

190 Views

Last post by frodo
Mon May 11, 2020 3:16 am
New mimic set appart from MS

Last post by frodo « Tue May 05, 2020 5:09 am

by frodo » Tue May 05, 2020 5:09 am

This report speaks about a newly found kind of neurodegeneration that looks like PPMS. Some previously diagnosed PPMS patients are probably suffering...

0 Replies

205 Views

Last post by frodo
Tue May 05, 2020 5:09 am
CD20+ B-cell subsets in MS

Last post by frodo « Tue May 05, 2020 4:46 am

by frodo » Tue May 05, 2020 4:46 am

B-cells are known to play a role in MS. Specially those with the protein CD20, because anti-CD20 mabs slow the evolution of the disease.

This study...

0 Replies

186 Views

Last post by frodo
Tue May 05, 2020 4:46 am
Two micro-RNAs (146 and 145) as markers for inflammation

Last post by frodo « Tue May 05, 2020 2:33 am

by frodo » Tue May 05, 2020 2:33 am

Investigation the miRNA146a and miRNA155 gene expression levels in patients with multiple sclerosis

Highlights

• MicroRNA-146a and...

0 Replies

163 Views

Last post by frodo
Tue May 05, 2020 2:33 am
new MS mimic and biotin

Last post by frodo « Mon May 04, 2020 5:02 am

by frodo » Mon May 04, 2020 5:02 am

Biotin deficiency can appear as MS but it is not MS.

Any individual with multiple sclerosis who markedly improves neurologically with high-doses of...

0 Replies

234 Views

Last post by frodo
Mon May 04, 2020 5:02 am
Molecular biomarker could be pathogenic

Last post by frodo « Mon May 04, 2020 1:34 am

by frodo » Mon May 04, 2020 1:34 am

Chitinase 3-like 1 is neurotoxic in primary cultured neurons

Abstract

Chitinase 3-like 1 (CHI3L1) is known to play a role as prognostic...

0 Replies

206 Views

Last post by frodo
Mon May 04, 2020 1:34 am
NAWM (normal appearing white matter) description

Last post by frodo « Thu Apr 30, 2020 9:02 am

by frodo » Thu Apr 30, 2020 9:02 am

Two new papers about NAWM that point to metabolic changes

perilesional-NAWM is characterized by lower myelin and axonal content compared to...

0 Replies

152 Views

Last post by frodo
Thu Apr 30, 2020 9:02 am
new biomarker for citrullination (myelin degeneration)

Last post by frodo « Wed Apr 29, 2020 2:18 am

by frodo » Wed Apr 29, 2020 2:18 am

New Chemical Probes for Detection of Molecular Markers of Multiple Sclerosis

Abstract

Multiple sclerosis is a neurodegenerative disease of...

0 Replies

128 Views

Last post by frodo
Wed Apr 29, 2020 2:18 am
Overlaps of MS with NMO and anti-MOG

Last post by frodo « Wed Apr 29, 2020 2:11 am

by frodo » Wed Apr 29, 2020 2:11 am

An Attempt to Subclassify and Understand Further the MS/NMOSD “Overlap” Syndromes and Beyond

Abstract

Objective: An attempt to define and...

0 Replies

118 Views

Last post by frodo
Wed Apr 29, 2020 2:11 am
Diversity of IgGs in CSF

Last post by frodo « Wed Apr 29, 2020 2:06 am

by frodo » Wed Apr 29, 2020 2:06 am

IgGs in CSF are active in the hydroysis of some proteins. Maybe a new biomarker?

Abstract

It was recently shown that IgGs from sera of...

0 Replies

87 Views

Last post by frodo
Wed Apr 29, 2020 2:06 am
Another important immunoglobuling in CSF: IgA

Last post by frodo « Tue Apr 28, 2020 4:26 am

by frodo » Tue Apr 28, 2020 4:26 am

Development of the technique of isoelectricfocusing and immunodetection of immunoglobulin A in the healthcare context as support for the diagnosis of...

0 Replies

120 Views

Last post by frodo
Tue Apr 28, 2020 4:26 am
2011 proposal: environment is MS' main cause; genetics minor

Last post by Petr75 « Sat Apr 25, 2020 10:57 pm
Replies: 5
by jimmylegs » Thu Aug 30, 2018 10:32 am

First post

The major cause of multiple sclerosis is environmental: genetics has a minor role - Yes (2011)

Proposal
It is clear that multiple sclerosis (MS)...

Last post

2020 Apr
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Environmental factors and risk of multiple...

5 Replies

1204 Views

Last post by Petr75
Sat Apr 25, 2020 10:57 pm
passing REAL MS to mice. New report 2020. An IgG-driven kind of MS found.

Last post by frodo « Wed Apr 22, 2020 12:41 am

by frodo » Wed Apr 22, 2020 12:41 am

There have been several reports previously about passing real PPMS (not RRMS nor SPMS) to mice by injections of CSF from patients. See for instance...

0 Replies

197 Views

Last post by frodo
Wed Apr 22, 2020 12:41 am
retinal layer atrophy in PPMS/SPMS

Last post by frodo « Fri Apr 17, 2020 1:42 am

by frodo » Fri Apr 17, 2020 1:42 am

This could shade some light into the pathogenesis. By the way, there is no myelin in the retina.

Progressive multiple sclerosis is associated...

0 Replies

207 Views

Last post by frodo
Fri Apr 17, 2020 1:42 am
Microglia in MS. Review.

Last post by frodo « Sun Apr 12, 2020 11:54 pm

by frodo » Sun Apr 12, 2020 11:54 pm

Microglia in Multiple Sclerosis: Friend or Foe?

Abstract

Microglia originate from myeloid progenitors in the embryonic yolk sac and play an...

0 Replies

203 Views

Last post by frodo
Sun Apr 12, 2020 11:54 pm
Human herpesvirus (HHV)-6A vs HHV-6B

Last post by frodo « Sun Apr 12, 2020 11:07 pm

by frodo » Sun Apr 12, 2020 11:07 pm

It seems that HHV-6A is associated to MS and its etiology. These resarchers found an increased serological response against a HHV-6A protein in MS....

0 Replies

185 Views

Last post by frodo
Sun Apr 12, 2020 11:07 pm
This looks important but I need help to understand it.

Last post by frodo « Sat Apr 11, 2020 3:15 am
Replies: 2
by frodo » Wed Apr 08, 2020 2:23 am

First post

This paper looks important. They have even made a video to explain it, but I cannot understand it. If anyone of you knows what are they talking about...

Last post

Thank you. I was expecting something more concrete, but it is interesting anyway.

2 Replies

276 Views

Last post by frodo
Sat Apr 11, 2020 3:15 am
Hints for a new astrocytic target

Last post by frodo « Fri Apr 03, 2020 3:20 am

by frodo » Fri Apr 03, 2020 3:20 am

After the discovery of AQP4 and MOG it seems that there is room for a third astrocytic target (this paper talks about NMOSD but it could include...

0 Replies

429 Views

Last post by frodo
Fri Apr 03, 2020 3:20 am
Epstein Bar Virus - A Review of the Epstein Barr Virus in Relationship to MS

Last post by Scott1 « Thu Mar 26, 2020 7:02 pm
Replies: 4
by Kinora » Fri May 03, 2019 9:08 am

First post

+

With Poem-The Long and Winding Road reinterpreted.

Last post

Hi,
I don't think that there is a contraindication if you take both but I'd check the dosing. You can't cut a slice of butter with a sledgehammer. It...

4 Replies

735 Views

Last post by Scott1
Thu Mar 26, 2020 7:02 pm
one of the mi-RNA predicts response to interferon

Last post by frodo « Fri Mar 13, 2020 4:50 am

by frodo » Fri Mar 13, 2020 4:50 am

miR-504 expression level is increased in multiple sclerosis patients responder to interferon-beta

Abstract

Multiple sclerosis is...

0 Replies

1963 Views

Last post by frodo
Fri Mar 13, 2020 4:50 am
OCBs in MS target patient-specific peptides

Last post by frodo « Tue Feb 25, 2020 4:51 am

by frodo » Tue Feb 25, 2020 4:51 am

New data speaking about different MS pathogenesis in each patient. It seems that a OCB signature has never been found because it does not exist. OCBs...

0 Replies

1249 Views

Last post by frodo
Tue Feb 25, 2020 4:51 am

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