Praha - Staromák - 23.2.2025
Tropospheric ozone
Re: Tropospheric ozone
2025 Mar
Association of early life co-exposure to ambient PM2.5 and O3 with the offspring's growth within two years of age: A birth cohort study
https://pubmed.ncbi.nlm.nih.gov/39805190/
Association of early life co-exposure to ambient PM2.5 and O3 with the offspring's growth within two years of age: A birth cohort study
https://pubmed.ncbi.nlm.nih.gov/39805190/
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Jan 12
Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
https://pubmed.ncbi.nlm.nih.gov/39800945/
..Conclusion: Increased fire smoke PM2.5 was associated with RA-ILD, whereas NOx, ozone, and PM10 were associated with RA risk. Thus, air pollution may increase the risk of RA and RA-ILD.
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MS
Mar 25, 2024
How Are Multiple Sclerosis and Rheumatoid Arthritis Connected?
https://www.healthcentral.com/condition ... -arthritis
Although multiple sclerosis (MS) and rheumatoid arthritis (RA) are two separate and distinct autoimmune disorders, research has suggested that there may be an association between the two. In other words, if you have one of these conditions, you may be more likely to develop the other...
2025 Jan 12
Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease
https://pubmed.ncbi.nlm.nih.gov/39800945/
..Conclusion: Increased fire smoke PM2.5 was associated with RA-ILD, whereas NOx, ozone, and PM10 were associated with RA risk. Thus, air pollution may increase the risk of RA and RA-ILD.
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MS
Mar 25, 2024
How Are Multiple Sclerosis and Rheumatoid Arthritis Connected?
https://www.healthcentral.com/condition ... -arthritis
Although multiple sclerosis (MS) and rheumatoid arthritis (RA) are two separate and distinct autoimmune disorders, research has suggested that there may be an association between the two. In other words, if you have one of these conditions, you may be more likely to develop the other...
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 16
Sleep duration and efficiency moderate the effects of prenatal and childhood ambient pollutant exposure on global white matter microstructural integrity in adolescence
Results: Sleep duration interacted with childhood NO 2 exposure and sleep efficiency interacted with prenatal O 3 exposure to affect RND at ages 10-13 years. Longer sleep duration and higher sleep efficiency in the context of higher pollutant exposure was associated with lower RND compared to those with similar pollutant exposure but shorter sleep duration and lower sleep efficiency.
Sleep duration and efficiency moderate the effects of prenatal and childhood ambient pollutant exposure on global white matter microstructural integrity in adolescence
Results: Sleep duration interacted with childhood NO 2 exposure and sleep efficiency interacted with prenatal O 3 exposure to affect RND at ages 10-13 years. Longer sleep duration and higher sleep efficiency in the context of higher pollutant exposure was associated with lower RND compared to those with similar pollutant exposure but shorter sleep duration and lower sleep efficiency.
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 15
Response of ozone to current and future emission scenarios and the resultant human health impact in Southeast Asia
https://pubmed.ncbi.nlm.nih.gov/39999484/
.. Abstract
Recent evidence has shown the increasing trend of tropospheric ozone (O3) in Southeast Asia. Mitigating O3 pollution in Southeast Asia has become important and urgent
Response of ozone to current and future emission scenarios and the resultant human health impact in Southeast Asia
https://pubmed.ncbi.nlm.nih.gov/39999484/
.. Abstract
Recent evidence has shown the increasing trend of tropospheric ozone (O3) in Southeast Asia. Mitigating O3 pollution in Southeast Asia has become important and urgent
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Feb 1
Ozone Exposure and Gestational Diabetes in Twin Pregnancies: Exploring Critical Windows and Synergistic Risks
https://pubmed.ncbi.nlm.nih.gov/39997932/
.. The critical windows were identified in the period from the 3rd week before gestation to the 2nd gestational week as well as from the 17th to 19th gestational week..
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MS
2021 Oct
Maternal diabetes and risk of multiple sclerosis in the offspring: A Danish nationwide register-based cohort study
https://pubmed.ncbi.nlm.nih.gov/33332240/
Conclusion: Our nationwide cohort study utilizing high-quality register data in Denmark over several decades corroborates the view that offspring of diabetic mothers may be at an elevated risk of developing MS.
2025 Feb 1
Ozone Exposure and Gestational Diabetes in Twin Pregnancies: Exploring Critical Windows and Synergistic Risks
https://pubmed.ncbi.nlm.nih.gov/39997932/
.. The critical windows were identified in the period from the 3rd week before gestation to the 2nd gestational week as well as from the 17th to 19th gestational week..
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MS
2021 Oct
Maternal diabetes and risk of multiple sclerosis in the offspring: A Danish nationwide register-based cohort study
https://pubmed.ncbi.nlm.nih.gov/33332240/
Conclusion: Our nationwide cohort study utilizing high-quality register data in Denmark over several decades corroborates the view that offspring of diabetic mothers may be at an elevated risk of developing MS.
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Feb 20
The Relationship Between Air Pollution, Meteorological Factors, and Eosinophil Counts in Peripheral Blood of Patients With Allergic Rhinitis: A Cross-Sectional Study
https://pubmed.ncbi.nlm.nih.gov/40017622/
Conclusion: Elevated eosinophil counts in AR patients correlated significantly with higher temperature, humidity, and O3 levels. Linear regression confirmed positive associations between eosinophil count and these meteorological factors.
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Autoimmune Diseases
2017 Apr 27
Eosinophils in Autoimmune Diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC5406413/
Abstract
Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases ..
Eosinophils may contribute to the initiation of autoimmune responses by presenting antigen to and activating T cells...
In summary, tissue eosinophils are increased in patients with inflammatory bowel diseases..
Eosinophils form a major part of the inflammatory infiltrate in subtypes of myocarditis ..
2025 Feb 20
The Relationship Between Air Pollution, Meteorological Factors, and Eosinophil Counts in Peripheral Blood of Patients With Allergic Rhinitis: A Cross-Sectional Study
https://pubmed.ncbi.nlm.nih.gov/40017622/
Conclusion: Elevated eosinophil counts in AR patients correlated significantly with higher temperature, humidity, and O3 levels. Linear regression confirmed positive associations between eosinophil count and these meteorological factors.
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Autoimmune Diseases
2017 Apr 27
Eosinophils in Autoimmune Diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC5406413/
Abstract
Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases ..
Eosinophils may contribute to the initiation of autoimmune responses by presenting antigen to and activating T cells...
In summary, tissue eosinophils are increased in patients with inflammatory bowel diseases..
Eosinophils form a major part of the inflammatory infiltrate in subtypes of myocarditis ..
https://www.eboro.cz
Re: Tropospheric ozone
2025 Feb 27
Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000-2019
https://pubmed.ncbi.nlm.nih.gov/40026655/
..Global SB emission increased the ambient PM2.5 (particulate matter with aerodynamic diameters ≤ 2.5 μm) and ozone (O3) concentrations up to 23.61 μg /m3 and 13.69 ppbv,..
Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000-2019
https://pubmed.ncbi.nlm.nih.gov/40026655/
..Global SB emission increased the ambient PM2.5 (particulate matter with aerodynamic diameters ≤ 2.5 μm) and ozone (O3) concentrations up to 23.61 μg /m3 and 13.69 ppbv,..
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Mar 3
Oxidation by ozone of linoleic acid monolayers at the air-water interface in multi-component films at 21 °C and 3 °C
https://pubmed.ncbi.nlm.nih.gov/40029211/
..Our work demonstrates clearly that it is essential to employ atmospherically realistic ozone levels as well as multi-component mixtures especially to understand LOA behaviour at low O3 in the atmosphere. While the temperature change did not play a crucial role for the kinetics, residue formation may be affected, potentially impacting on the persistence of the organic character at the surface of aqueous droplets with a wide range of atmospheric implications.
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MS
October 1983
Double-blind Trial of Linoleic Acid in Multiple Sclerosis
https://jamanetwork.com/journals/jamane ... act/582368
Abstract
Studies of linoleic acid levels in the blood of patients with multiple sclerosis (MS) have suggested that these levels drop during acute exacerbations.1 This prompted Millar et al2 to undertake a double-blind study of the effects of linoleic acid administration on the course of MS. The trial was conducted in two independent centers (London and Belfast). Seventy-five patients were studied in a doubleblind protocol. Clinical scoring employed the Kurtzke disability status scale3 and a method for scoring severity of relapses.2 At the end of the trial, the latter showed a significant reduction in both numbers and severity of relapses in the linoleic acid-treated group. No long-term beneficial effects were detected. My colleagues and I attempted to confirm these observations, using timed studies of functional ability, the Kurtzke disability status scale, and the Kurtzke functional scales as measures of neurologic involvement.
2025 Mar 3
Oxidation by ozone of linoleic acid monolayers at the air-water interface in multi-component films at 21 °C and 3 °C
https://pubmed.ncbi.nlm.nih.gov/40029211/
..Our work demonstrates clearly that it is essential to employ atmospherically realistic ozone levels as well as multi-component mixtures especially to understand LOA behaviour at low O3 in the atmosphere. While the temperature change did not play a crucial role for the kinetics, residue formation may be affected, potentially impacting on the persistence of the organic character at the surface of aqueous droplets with a wide range of atmospheric implications.
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MS
October 1983
Double-blind Trial of Linoleic Acid in Multiple Sclerosis
https://jamanetwork.com/journals/jamane ... act/582368
Abstract
Studies of linoleic acid levels in the blood of patients with multiple sclerosis (MS) have suggested that these levels drop during acute exacerbations.1 This prompted Millar et al2 to undertake a double-blind study of the effects of linoleic acid administration on the course of MS. The trial was conducted in two independent centers (London and Belfast). Seventy-five patients were studied in a doubleblind protocol. Clinical scoring employed the Kurtzke disability status scale3 and a method for scoring severity of relapses.2 At the end of the trial, the latter showed a significant reduction in both numbers and severity of relapses in the linoleic acid-treated group. No long-term beneficial effects were detected. My colleagues and I attempted to confirm these observations, using timed studies of functional ability, the Kurtzke disability status scale, and the Kurtzke functional scales as measures of neurologic involvement.
https://www.eboro.cz
Re: Tropospheric ozone
Linoleic acid is an omega-6 fat that's usually considered to be proinflammatory.
Re: Tropospheric ozone
2025 Mar 2Petr75 wrote: ↑Tue Aug 20, 2024 11:23 am2024 Jul 11Petr75 wrote: ↑Sun Jun 16, 2024 9:59 am O3
November 2022
Ambient ozone pollution and prevalence of chronic kidney disease: A nationwide study based on the China National survey of chronic kidney disease
https://www.sciencedirect.com/science/a ... 3522020963
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MS
2022 Dec 2
Renal diseases associated with multiple sclerosis: A narrative review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726425/
..Conclusion
Although kidney disease can be associated with MS, few cases have been reported in the literature. The pathogenesis of renal disease in these patients can be related to lower urinary tract dysfunction, recurrent UTI, and treatment with immunomodulatory agents such as interferons. Therefore, neurologists and other physicians managing patients with MS should be aware of the risk of renal disease and monitor patients’ renal function closely during the course of treatment. Further studies are needed to explore renal diseases and their prevention in patients with MS.
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2024 Jul
Regarding the "Renal dysfunction in AQP4 NMOSD and MS; a potential predictor of relapse and prognosis"
https://pubmed.ncbi.nlm.nih.gov/38763434/
(No abstract available)
Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea
Air pollution and acute kidney injury with comorbid disease: A nationwide case-crossover study in South Korea
https://pubmed.ncbi.nlm.nih.gov/39002627/
Abstract
Emerging evidence suggests that air pollution is a significant contributor to the global burden of kidney disease...
Ozone exposure induced kidney damage in diabetic mice: the key role of lipid metabolism and water-electrolyte homeostasis
https://pubmed.ncbi.nlm.nih.gov/40037426/
https://www.eboro.cz
Re: Tropospheric ozone
2025 Mar 6
Enhanced Soil Emissions of Reactive Nitrogen Gases by Fertilization and Their Impacts on Secondary Air Pollution in Eastern China
https://pubmed.ncbi.nlm.nih.gov/40051057/
..It is estimated that the Nr emissions from a typical fertilization event in the Yangtze River Delta (YRD) region increased ozone (O3) and nitrate concentrations by 2.5 and 18.2%, respectively. HONO and NH3 emissions jointly enhanced nitrate production via gas-particle partitioning.
Enhanced Soil Emissions of Reactive Nitrogen Gases by Fertilization and Their Impacts on Secondary Air Pollution in Eastern China
https://pubmed.ncbi.nlm.nih.gov/40051057/
..It is estimated that the Nr emissions from a typical fertilization event in the Yangtze River Delta (YRD) region increased ozone (O3) and nitrate concentrations by 2.5 and 18.2%, respectively. HONO and NH3 emissions jointly enhanced nitrate production via gas-particle partitioning.
https://www.eboro.cz
Re: Tropospheric ozone
O3
May 2023
Plasma sterols and vitamin D are correlates and predictors of ozone-induced inflammation in the lung: A pilot study
https://www.researchgate.net/publicatio ... ilot_study
.. We use computational analyses including machine learning to determine whether baseline plasma sterols are predictive of O3 responsiveness. Results We observed an overall decrease in the concentration of cholesterol precursors and derivatives (e.g. 27-hydroxycholesterol) and an increase in concentration of autooxidation products (e.g. secosterol-B) in sputum samples.
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MS
2025 Mar 5
Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/40045480/
Abstract
Disability worsening in multiple sclerosis (MS) is linked to neurodegeneration. Cholesterol homeostasis is essential for normal brain function. ...
.. Significant dysregulation in 25-hydroxycholesterol, 27-hydroxycholesterol and 3β-hydroxycholestenoic acid in CSF correlated with disability at baseline and follow-up in the patient population. In brain tissue, reduced cholesterol, 24S-hydroxycholesterol and 24S,25-epoxycholesterol were observed in white matter lesions...
May 2023
Plasma sterols and vitamin D are correlates and predictors of ozone-induced inflammation in the lung: A pilot study
https://www.researchgate.net/publicatio ... ilot_study
.. We use computational analyses including machine learning to determine whether baseline plasma sterols are predictive of O3 responsiveness. Results We observed an overall decrease in the concentration of cholesterol precursors and derivatives (e.g. 27-hydroxycholesterol) and an increase in concentration of autooxidation products (e.g. secosterol-B) in sputum samples.
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MS
2025 Mar 5
Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis
https://pubmed.ncbi.nlm.nih.gov/40045480/
Abstract
Disability worsening in multiple sclerosis (MS) is linked to neurodegeneration. Cholesterol homeostasis is essential for normal brain function. ...
.. Significant dysregulation in 25-hydroxycholesterol, 27-hydroxycholesterol and 3β-hydroxycholestenoic acid in CSF correlated with disability at baseline and follow-up in the patient population. In brain tissue, reduced cholesterol, 24S-hydroxycholesterol and 24S,25-epoxycholesterol were observed in white matter lesions...
https://www.eboro.cz
Re: Tropospheric ozone
O3
2025 Mar 10
The effect of tropospheric low-value ozone exposure on the mortality risk of ischemic heart disease and stroke on the example of Yibin (southwestern China)
https://pubmed.ncbi.nlm.nih.gov/40063105/
This study consolidates the evidence for a positive correlation between low-level O3 exposure and the mortality risk of IHD and stroke. The findings provide preliminary exploratory insights into the potential impact of air pollution on these diseases, offering a valuable reference for future research.
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MS
2022 Mar 15
Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC8964627/
Conclusions
We provided suggestive genetic evidence for the causal associations of MS with increased risk of CAD, MI, HF, AS, and AIS, which highlighted the significance of active monitoring and prevention of cardiovascular risk to combat cardiovascular comorbidities in MS patients.
2025 Mar 10
The effect of tropospheric low-value ozone exposure on the mortality risk of ischemic heart disease and stroke on the example of Yibin (southwestern China)
https://pubmed.ncbi.nlm.nih.gov/40063105/
This study consolidates the evidence for a positive correlation between low-level O3 exposure and the mortality risk of IHD and stroke. The findings provide preliminary exploratory insights into the potential impact of air pollution on these diseases, offering a valuable reference for future research.
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MS
2022 Mar 15
Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study
https://pmc.ncbi.nlm.nih.gov/articles/PMC8964627/
Conclusions
We provided suggestive genetic evidence for the causal associations of MS with increased risk of CAD, MI, HF, AS, and AIS, which highlighted the significance of active monitoring and prevention of cardiovascular risk to combat cardiovascular comorbidities in MS patients.
https://www.eboro.cz