Lipoic acid outperforms Ocrevus (Ocrelizumab)

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frodo
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Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by frodo » Thu Sep 21, 2017 8:24 pm

Source: https://www.medicalnewstoday.com/articl ... 5.php?iacp

Lipoic acid outperformed ocrelizumab

Whole brain atrophy refers to the reduction in total brain volume due to the loss of neurons, and it is considered a marker of MS progression.

For their randomized, double-blind study, Dr. Spain and team enrolled 51 adults aged between 40 and 70 years, all of whom had been diagnosed with SPMS.

A total of 27 participants were randomized to receive 1,200 milligrams of lipoic acid every day for 2 years, while the remaining 24 subjects received a placebo.

The brain volume of each participant was assessed at study baseline using MRI. MRI scans were also conducted each year thereafter, in order to pinpoint any changes in subjects' brain volume.

Compared with participants who took the placebo, the researchers found that those who took lipoic acid showed a 68 percent reduction in the rate of whole brain atrophy.

For comparative purposes, the team notes that the drug ocrelizumab (brand name Ocrevus) - which was recently approved by the Food and Drug Administration (FDA) for the treatment of primary progressive MS - improved whole brain atrophy by 18 percent in clinical trials.

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NHE
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Re: Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by NHE » Thu Sep 21, 2017 10:47 pm

frodo wrote:Source: https://www.medicalnewstoday.com/articl ... 5.php?iacp

Lipoic acid outperformed ocrelizumab
One wonders how much better their results would have been had they used a stabilized R-lipoic acid like Na-R-lipoate???

http://www.thisisms.com/forum/general-d ... ml#p248588

:confused:

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Re: Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by Zyklon » Sat Sep 23, 2017 12:05 pm

NHE, what do you think about http://www.solgar.com/solgarproducts/nu ... ftgels.htm ? Is it the right form lipoic acid? Thank you.
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Re: Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by NHE » Sun Sep 24, 2017 2:14 am

Zyklon wrote:NHE, what do you think about http://www.solgar.com/solgarproducts/nu ... ftgels.htm ? Is it the right form lipoic acid? Thank you.
All it says is "alpha lipoic acid." I think it's safe to assume that it's the racemic form, i.e., 50% R and 50% S. Otherwise, they would likely advertise that it was the purified R enantiomer. Try this one... https://www.vitacost.com/doctors-best-s ... ipoic-acid The "stabilized" part is that it's the sodium salt of lipoic acid. This keeps it from polymerizing in the bottle which would inactivate it. This process is accelerated with elevated temperatures.

More info... http://www.thisisms.com/forum/natural-a ... c4347.html

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Re: Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by David1949 » Sun Sep 24, 2017 11:58 am

How do we know what type of Lipoic acid they used? Why would we assume that something other than what they tested would be better?

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Re: Lipoic acid outperforms Ocrevus (Ocrelizumab)

Post by NHE » Sun Sep 24, 2017 10:48 pm

David1949 wrote:How do we know what type of Lipoic acid they used?
We know what type of lipoic acid was used because it's in their published journal paper.

http://nn.neurology.org/content/4/5/e374.full.pdf
Investigational drug.
An Investigational New Drug indication was obtained by the PI (no. 110132). Pure Encapsulations (Sudbury, MA) provided gelatin capsules containing 600 mg racemic LA or placebo. Placebo capsules contained Avicel (microcellulose crystal) and 4.3 mg of quercetin (a bioflavonoid) that rendered the placebo a yellow color, similar to LA.
David1949 wrote:Why would we assume that something other than what they tested would be better?
Racemic lipoic acid is 50% S enantiomer. The S form is a byproduct of chemical synthesis. Only the R form is natural and what our bodies use. Moreover, the S form has negative physiological costs.

http://www.thisisms.com/forum/natural-a ... tml#p29715

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