EBV reported 100% in a MS croatian sample

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frodo
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EBV reported 100% in a MS croatian sample

Post by frodo » Fri Feb 23, 2018 2:09 am

We already knew about the 100% prevalence, but it is confirmed again:

Seroepidemiological Study of Epstein-Barr Virus in Different Population Groups in Croatia.



Abstract
The Epstein-Barr virus (EBV) is one of the most common viruses found in humans, causing lifelong infection in up to 95% of the world population.To analyze the seroprevalence of EBV infection in different population groups in Croatia.During a 2 year period (2015-2016), a total of 2022 consecutive serum samples collected from Croatian residents were tested for the presence of EBV-specific viral capsid antigen (VCA) immunoglobulin M (IgM) and IgG antibodies using an enzyme-linked immunoassay. IgM/IgG-positive samples were further tested for IgG avidity.The overall prevalence of EBV IgG antibodies was 91.4%. Females had significantly higher IgG seroprevalence than males (93.1% vs. 89.9%, P = 0.008). According to age, IgG seropositivity increased progressively from 59.6% in children age < 9 years to 98.3% in 30-39 year olds, and remained stable thereafter (P < 0.001). The IgG seroprevalence differed significantly among groups: 68.1% in children/adolescents and 95.9% in adults; multiple sclerosis (100%), hemodialysis patients (97.7%), heart transplant recipients (93.8%), hematological malignancies (91.2%), and Crohn's disease (88.5%), P < 0.001. IgM antibodies were detected in 9% of participants. Using IgG avidity, recent primary EBV infection was documented in 83.8% of IgM-positive subjects < 9 years old, 69.2% age 10-19, 33.3% age 20-29, and 3.6-4.2% > 40. All IgM positive participants > 40 years showed high IgG avidity. Logistic regression showed that age is associated with EBV IgG seropositivity.EBV is widespread in the Croatian population. Older age appears to be the main risk factor for EBV seropositivity.

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Re: EBV reported 100% in a MS croatian sample

Post by David1949 » Fri Feb 23, 2018 11:50 am

This is another study that makes EBV look like the smoking gun. But when you look at the underlying numbers it's not so certain. The study included 2022 participants. If these people represent a random cross section of Croatians then only about 3 of them were likely to have MS. (The prevalence of MS in Croatia is about 151.9 per 100,000 inhabitants https://www.ncbi.nlm.nih.gov/pubmed/16806273)
That's far too small to be statistically meaningful. Given that 91.4% of the population has the virus then if you pick 3 people at random it is quite likely that all of them would have it.

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Re: EBV reported 100% in a MS croatian sample

Post by frodo » Tue Feb 27, 2018 3:20 am

David1949 wrote:This is another study that makes EBV look like the smoking gun. But when you look at the underlying numbers it's not so certain. The study included 2022 participants. If these people represent a random cross section of Croatians then only about 3 of them were likely to have MS. (The prevalence of MS in Croatia is about 151.9 per 100,000 inhabitants https://www.ncbi.nlm.nih.gov/pubmed/16806273)
That's far too small to be statistically meaningful. Given that 91.4% of the population has the virus then if you pick 3 people at random it is quite likely that all of them would have it.
Yes. It is clear that EBV is not the only factor, but it also seems clear that is one of the factors.

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