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Post by koneall » Tue Apr 10, 2018 3:20 pm

Since it's more common in women than men, I wondered whether testosterone might be the reason. I found this abstract:

Arch Neurol. 2007;64(5):683-688. doi:10.1001/archneur.64.5.683

Objective To study the effect of testosterone supplementation on men with multiple sclerosis (MS).

Design, Setting, and Participants Men are less susceptible to many autoimmune diseases, including MS. Possible causes for this include sex hormones and/or sex chromosome effects. Testosterone treatment ameliorates experimental allergic encephalomyelitis, an animal model of MS, but the effect of testosterone supplementation on men with MS is not known. Therefore, 10 men with relapsing-remitting MS were studied using a crossover design whereby each patient served as his own control. There was a 6-month pretreatment period followed by a 12-month period of daily treatment with 10 g of the gel containing 100 mg of testosterone.

Main Outcome Measures Clinical measures of disability and cognition (the Multiple Sclerosis Functional Composite and the 7/24 Spatial Recall Test) and monthly magnetic resonance imaging measures of enhancing lesion activity and whole brain volumes.

Results One year of treatment with testosterone gel was associated with improvement in cognitive performance (P = .008) and a slowing of brain atrophy (P <.001). There was no significant effect of testosterone treatment on gadolinium-enhancing lesion numbers (P = .31) or volumes (P = .94). Lean body mass (muscle mass) was increased (P = .02).

Conclusion These exploratory findings suggest that testosterone treatment is safe and well tolerated.

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Re: testosterone?

Post by jimmylegs » Tue Apr 10, 2018 5:01 pm

a history of related posts may contain items of interest: https://bit.ly/2GNEGfA
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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