Link Between Gut Flora and Multiple Sclerosis Discovered

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frodo
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Re: Link Between Gut Flora and Multiple Sclerosis Discovered

Post by frodo » Tue Oct 30, 2018 11:56 pm

Petr75 wrote:2017 Jul 18
Glucocorticoid-associated blood glucose response and MS relapse recovery
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515601/

..Our data provide important insights into 1 possible mechanism that impaired glucose tolerance may be contributing to increased progression among patients with MS, even those without a confirmed diagnosis of diabetes.
Great finding!! it also fits in the global picture. I really think they are on the right path.

... they tested 200 fragment mixtures, each containing 300 billion varieties. The two fragments with the strongest effect turned out to be part of a human enzyme called guanosine diphosphate-L-fucose synthase, which helps cells remodel sugars ...

Kheuer
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Re: Link Between Gut Flora and Multiple Sclerosis Discovered

Post by Kheuer » Wed Oct 31, 2018 4:42 am

Actually, it is CD20 b cells that cause an inflammatory cascade initially, resulting in demyelination and abnormal re-myelination. New evidence has identified that B cells in persons with MS activate T-cells to become pathogenic so the result is many T cells are found in some of the larger lesions and remain there

Kheuer
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Re: Link Between Gut Flora and Multiple Sclerosis Discovered

Post by Kheuer » Wed Oct 31, 2018 4:45 am

It actually makes sense that in Ms part of the pathology is that B cells activate T-cells to become pathogenic because in some types of immunizations like tetanus for example the B cells Ferry the toxoid to the T cell to train the T-cell to recognize the toxoid as something to create an antigen against and therefore you have protection against the tetanus toxoids

Kheuer
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Re: Link Between Gut Flora and Multiple Sclerosis Discovered

Post by Kheuer » Wed Oct 31, 2018 4:48 am

Of note memory B cells are actually implicated in Guillain-Barre syndrome which is another demyelinating disease

https://www.ncbi.nlm.nih.gov/m/pubmed/28284328/

Memory B cells in Guillain-Barré syndrome.

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Petr75
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Re: Link Between Gut Flora and Multiple Sclerosis Discovered

Post by Petr75 » Wed Oct 31, 2018 11:51 am


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