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Post by Petr75 » Sun Nov 11, 2018 11:06 am

2018 Oct 18
The Department of Pediatrics, Division of Gastroenterology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston
Probiotics in Autoimmune and Inflammatory Disorders

Probiotics have been used to ameliorate gastrointestinal symptoms since ancient times. Over the past 40 years, probiotics have been shown to impact the immune system, both in vivo and in vitro. This interaction is linked to gut microbes, their polysaccharide antigens, and key metabolites produced by these bacteria. At least four metabolic pathways have been implicated in mechanistic studies of probiotics, based on mechanistic studies in animal models. Microbial⁻immune system crosstalk has been linked to: short-chain fatty acid production and signaling, tryptophan metabolism and the activation of aryl hydrocarbon receptors, nucleoside signaling in the gut, and activation of the intestinal histamine-2 receptor. Several randomized controlled trials have now shown that microbial modification by probiotics may improve gastrointestinal symptoms and multiorgan inflammation in rheumatoid arthritis, ulcerative colitis, and multiple sclerosis. Future work will need to carefully assess safety issues, selection of optimal strains and combinations, and attempts to prolong the duration of colonization of beneficial microbes.


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Re: Probiotics

Post by ElliotB » Sun Nov 11, 2018 3:36 pm

"Over the past 40 years, probiotics have been shown to impact the immune system"

Knowledge about probiotics dates back over well over 100 years, and the consumption of fermented foods and drinks and the knowledge that there were numerous health benefits to be had from the consumption of these fermented items dates back many centuries.

Here is a link to a summary of "The History of Probiotics" ... probiotics

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