Thoracic cavity venous flow

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Petr75
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Thoracic cavity venous flow

Post by Petr75 » Mon Oct 28, 2019 1:00 am

2019 Oct
T. Tucker Inc., Ottawa, Ontario, Canada
Fluid dynamics of thoracic cavity venous flow in multiple sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/31443776

Abstract
This paper hypothesizes, based on fluid dynamics principles, that in multiple sclerosis (MS) non-laminar, vortex blood flow occurs in the superior vena cava (SVC) and brachiocephalic veins (BVs), particularly at junctions with their tributary veins. The physics-based analysis demonstrates that the morphology and physical attributes of the major thoracic veins, and their tributary confluent veins, together with the attributes of the flowing blood, predict transition from laminar to non-laminar flow, primarily vortex flow, at select vein curvatures and junctions. Non-laminar, vortex flow results in the development of immobile stenotic valves and intraluminal flow obstructions, particularly in the internal jugular veins (IJVs) and in the azygos vein (AV) at their confluences with the SVC or BVs. Clinical trials' observations of vascular flow show that regions of low and reversing flow are associated with endothelial malformation. The physics-based analysis predicts the growth of intraluminal flaps and septa at segments of vein curvature and flow confluences. The analysis demonstrates positive correlations between predicted and clinically observed elongation of valve leaflets and between the predicted and observed prevalence of immobile valves at various venous flow confluences. The analysis predicts the formation of sclerotic plaques at venous junctions and curvatures, in locations that are analogous to plaques in atherosclerosis. The analysis predicts that increasing venous compliance increases the laminarity of venous flow and reduces the prevalence and severity of vein malformations and plaques, a potentially significant clinical result. An over-arching observation is that the correlations between predicted phenomena and clinically observed phenomena are sufficiently positive that the physics-based approach represents a new means for understanding the relationships between venous flow in MS and clinically observed venous malformations.

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frodo
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Re: Thoracic cavity venous flow

Post by frodo » Mon Oct 28, 2019 1:17 am

Thanks. This reminds me that in the old times of CCSVI some reports appeared speaking about venous malformations in post-mortem autopsies of MS patients. For some reason, I never hear about that anymore.

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