Protective and Regenerative Roles of T Cells
Protective and Regenerative Roles of T Cells
The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, United Kingdom
Protective and Regenerative Roles of T Cells in Central Nervous System Disorders.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751344/
Abstract
Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4+ T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
Function of multiple sclerosis-protective HLA class I alleles
by Petr75 » Fri Nov 06, 2020 12:34 pm » in General Discussion - 0 Replies
- 316 Views
-
Last post by Petr75
Fri Nov 06, 2020 12:34 pm
-
-
-
Extrinsic defect in B cells differentiation through alteration of T FH cells
by frodo » Thu Jun 27, 2019 12:58 am » in MS Etiology and Pathogenesis - 0 Replies
- 673 Views
-
Last post by frodo
Thu Jun 27, 2019 12:58 am
-
-
-
anti-CD20 works on B-cells but also on T-cells
by frodo » Wed Aug 19, 2020 4:56 am » in MS Etiology and Pathogenesis - 0 Replies
- 190 Views
-
Last post by frodo
Wed Aug 19, 2020 4:56 am
-
-
- 0 Replies
- 90 Views
-
Last post by NHE
Fri Feb 26, 2021 8:16 am
-
- 0 Replies
- 349 Views
-
Last post by Petr75
Sat Dec 12, 2020 11:13 am
-
- 1 Replies
- 288 Views
-
Last post by Petr75
Mon Nov 16, 2020 11:49 am
-
- 0 Replies
- 558 Views
-
Last post by frodo
Tue Jun 25, 2019 7:18 am
-
-
Age of cells populations in MS
by frodo » Wed Jun 19, 2019 4:01 am » in MS Etiology and Pathogenesis - 0 Replies
- 507 Views
-
Last post by frodo
Wed Jun 19, 2019 4:01 am
-
-
- 0 Replies
- 319 Views
-
Last post by NHE
Sun Sep 20, 2020 2:53 pm