Therapies tageting B cells
Therapies tageting B cells
Croat Med J. 2019 Apr 30;60(2):87-98.
Increasing evidence suggests that B cells contribute both to the regulation of normal autoimmunity and to the pathogenesis of immune mediated diseases, including multiple sclerosis (MS). B cells in MS are skewed toward a pro-inflammatory profile, and contribute to MS pathogenesis by antibody production, antigen presentation, T cells stimulation and activation, driving autoproliferation of brain-homing autoreactive CD4+ T cells, production of pro-inflammatory cytokines, and formation of ectopic meningeal germinal centers that drive cortical pathology and contribute to neurological disability. The recent interest in the key role of B cells in MS has been evoked by the profound anti-inflammatory effects of rituximab, a chimeric monoclonal antibody (mAb) targeting the B cell surface marker CD20, observed in relapsing-remitting MS. This has been reaffirmed by clinical trials with less immunogenic and more potent B cell-depleting mAbs targeting CD20 - ocrelizumab, ofatumumab and ublituximab. Ocrelizumab is also the first disease-modifying drug that has shown efficacy in primary-progressive MS, and is currently approved for both indications. Another promising approach is the inhibition of Bruton's tyrosine kinase, a key enzyme that mediates B cell activation and survival, by agents such as evobrutinib. On the other hand, targeting B cell cytokines with the fusion protein atacicept increased MS activity, highlighting the complex and not fully understood role of B cells and humoral immunity in MS. Finally, all other approved therapies for MS, some of which have been designed to target T cells, have some effects on the frequency, phenotype, or homing of B cells, which may contribute to their therapeutic activity.
Free full text.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
Selective therapies are needed. Report about reation to B-cells treatment.
by frodo » Tue Apr 23, 2019 10:21 am » in General Discussion - 0 Replies
- 539 Views
-
Last post by frodo
Tue Apr 23, 2019 10:21 am
-
-
-
Extrinsic defect in B cells differentiation through alteration of T FH cells
by frodo » Thu Jun 27, 2019 12:58 am » in MS Etiology and Pathogenesis - 0 Replies
- 670 Views
-
Last post by frodo
Thu Jun 27, 2019 12:58 am
-
-
-
anti-CD20 works on B-cells but also on T-cells
by frodo » Wed Aug 19, 2020 4:56 am » in MS Etiology and Pathogenesis - 0 Replies
- 187 Views
-
Last post by frodo
Wed Aug 19, 2020 4:56 am
-
-
- 0 Replies
- 337 Views
-
Last post by Petr75
Sat Dec 12, 2020 11:13 am
-
- 1 Replies
- 287 Views
-
Last post by Petr75
Mon Nov 16, 2020 11:49 am
-
- 0 Replies
- 553 Views
-
Last post by frodo
Tue Jun 25, 2019 7:18 am
-
-
Age of cells populations in MS
by frodo » Wed Jun 19, 2019 4:01 am » in MS Etiology and Pathogenesis - 0 Replies
- 505 Views
-
Last post by frodo
Wed Jun 19, 2019 4:01 am
-
-
-
Protective and Regenerative Roles of T Cells
by Petr75 » Tue Nov 12, 2019 11:31 am » in General Discussion - 0 Replies
- 341 Views
-
Last post by Petr75
Tue Nov 12, 2019 11:31 am
-
-
- 0 Replies
- 1058 Views
-
Last post by Vivianne766
Wed Sep 18, 2019 5:08 pm