CONTROL RE-ACTIVATION OF THE EPSTEIN BARR VIRUS.

[vesta]

CONTROL RE-ACTIVATION OF THE EPSTEIN BARR VIRUS.
Only recently have I understood the importance of controlling re-activation of the Epstein Barr Virus, a Herpes virus which causes Mononucleosis, one of 4 typical factors in the development of MS according to the Neurologist researcher Dr Robert Zivadinov.
Yes , I fell ill with Mono at age 9. My first known MS attack occured 22 years later during a period of extreme stress – ballet performance stress doubtless exacerbated by a viral « cold ». I succeeded in halting the « attack » with a Shiatsu massage. I didn’t know why the massage put an end to the crisis until 30 years later when I learned about Dr Zamboni’s CCSVI work. Yes, tense muscles must have closed off the chest Azygous vein to trigger a blood back-jet onto the spine. A renowned British neurologist Dr. Pallis who examined me before a master class at the Hospital surmised that only half of the spinal cord had been damaged since the leg wasn’t paralysed like the arm. This was unusual.
It took maybe 2 months to really recover nerve damage and strength, but the massage abruprtly halted the process. I think the fact I DID recover without medication or Dr’s assistance gave me confidence I could heal on my own initiative. Later when the Dr gave a name to the illness, Multiple Sclerosis, I didn’t collapse in horror « Oh, I have a dread disease ! » Rather I decided to re-organize my life so I could heal. And I did heal several years later.
Chinese Medicine therapy by a Chinese Acupuncturist Dr who had been formed in China by a « Master » kept me going over the next few years. Coupled with bitter herb teas, the acupuncture treatments kept the blood circulating. On at least one occasion incipient paralysis in my feet stopped after a 2 hour acupuncture treatment. But I still gradually went downhill. For one, I was running a French Perfume shop « Parfums de Provence » in San Francisco which meant I was working in a toxic environment. I realized I could never heal until I closed the business to focus on healing. So when the lease was up I freed myself of the « lovely » toxic fumes and set forth in search of solution.
Six months later a massage therapist referred me to Dr Jimmy Scott, a Kinesiologist who had developed an integrated healing protocol based on « muscle testing ». He called his work « Health Kinesiology » based on the TouchForHealth work of the Chiropractor Dr John Thie. The 14 Chinese meridians (12 organ plus Central and Governing) are associated with muscle groups. When the meridians are « unbalanced » the muscles are weak. Once balanced, the corresponding muscle strengthens. Dr Scott developed a method to balance all the meridians quickly and then used the arm to ask the body questions about diet, supplements, emotions, etc. Sounds quackish, but it worked. Within a year I had healed « permanent » nerve damage. MY SEVEN STEPS TO MULTIPLE SCLEROSIS HEALTH give an overview of his protocol – detoxification, diet change, supplements, energy work.
He didn’t discover the blood/CSF circulation CCSVI issue. Rather, he focused on balancing the CHI or meridan energy circulation. My monthly visits must have kept the blood circulating until I had one setback when the decision to leave my husband triggered a stress attack.
O.K. Why did I go downhill so dramatically between Dec 2019 and May 2020 ?
For one thing a sleeping pill caused me to fall asleep while standing which sent me crashing to the floor in October 2019. (No more sedatives for me !) I broke my already damaged right arm. It healed OK but my arm was really handicapped after that. Later the Osteopath told me that the bunched up shoulder/arm position was throwing the pelvis off. After my last visit December 2019 I could still walk with a simple cane once he had adjusted the pelvis to release the legs. But when we traveled to Marbella for a winter stay, the Spanish Osteopath didn’t do the chiropractic type work which would have adjusted the pelvis. I realize now that it was during the stay in Spain that one leg became shorter than the other. My back/body was « twisted ».
Then of course the Covid « confinement » closed the Osteopath’s office. By the time I saw him again late May 2020, the damage was done. The lady Taxi driver exclaimed, shocked, « What happened to you » as I stumbled uncharacteristically on her arm late May 2020.
At the same time the Physical Therapist noticed a marked loss of strength in my « good » left leg. What happened ?
Apparently the EBV had re-emerged. As the Stanford scientists reported in 2022 research, the immune response must have attacked the protein in the myelin sheath at the same time as the protein in the EBV. I can’t recall any crisis which would have triggered a blood « back jet ». However, the « twist » in the spine must have restricted blood/CSF circulation creating a hypoxia low oxygen condition to re-awaken the dormant EBV.
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10958269
« EBNA1 (latency) seroreactivity increased in the pre-MS group, at 15–20 years before clinical MS onset…Conclusions Seroreactivity against latent and lytic EBV antigens, and in a subset ANO2, was detectable on average a decade before the appearance of a gradually increasing axonal injury occurring in the last decade before the onset of clinical MS. These findings strengthen the hypothesis of latent EBV involvement in the pathogenesis of MS. »
I fell ill with Mononucleosis in 1958. My first known « attack » occured 22 years later in 1980. I’m convinced the 1980 crisis was the consequence of a CCSVI type blood back jet. I might have avoided further deterioration had I faithfully followed my Seven Steps to MS Health launched in 1984. I think now that unless I can find someone to release the blood/CSF circulation, the MS will continue this severe (for me) Progression. Like any flu, the recent Covid infection cramped the muscles to restrict fluid circulations which weakened me further. If I was in California I would seek out a Rolfing therapist who might be able to release the muscles imprisoning my pelvis. (It would be a miracle if a nearby newly arrived Physical Therapist educated in Romania could do this work. My few visits suggest the possibility. We shall see once summer is over.)
In the meantime I will try to find a way to de-activate the EBV with medication. I will present the following list to my local MD and see if she has ideas. I just started taking Parthenolide (Feverfew) suggested by DIM, a TIMS https://www.thisisms.com participant, who does research on EBV to help his wife.
1. Famcyclovir (Stanford University, Herpes 6)
2. DIM Acyclovir (half infected B cells)
3. Valcycyclovir (Valtrex)
4. Sikonin
5. Apigenin
6. Parthenolide (Feverfew)
7. Ivermectin
8. Spironolactone https://medicalxpress.com/news/2020-…

Previously published on my site mscureenigmas.net https://www.mscureenigmas.net

[DIM]

FYI when my wife and I were infected by Covid-19 type B we took Ivermectin prescribed by a doctor friend in Mauritius.
They used this protocol in their hospitals along with other drugs like Azithromycin and some vitamins etc.
And while I had fever and was sick, my wife was pretty much perfect all 10 days of Ivermectin treatment while having some kind of MS remission!

I don't know for sure if it was from the Ivermectin or her immune response to the Covid.
But the next time we were infected by Covid-19 type D and we did not take either Ivermectin or Budesonide (another drug more suitable for the D mutation according to our doctor) she became very ill with 39C fever, great difficulty in walking and her MS worsened significantly.

I know it's a very short interval of taking Ivermectin for it to make a difference in EBV, I'm just stating my experience.

I am searching also the best EBV medication with less possible long term side effects, and I think first candidate is Valacyclovir which is quickly metabolized in the body to Acyclovir, what is your opinion?

PS: You forgot the Dipyridamole in your anti-EBV list

[NHE]

Please see my prior post where I did a brief literature review on using valacyclovir to treat EBV.

viewtopic.php?t=32424

[Scott1]

The trick is to use a product that causes chain termination of the replication of the viral DNA. However, EBV replicates two ways -1) Latently, where the virus is inside the host cell and replicates as the cell divides or 2) via Lytic replication, when the host cell becomes full of viral particles and bursts, spreading the virus prolifically.
Our immune system needs to see what it regards as a non-self invader to trigger a reaction. That means the viral peptides need to be presented on the surface of the host cell, and then be regarded as potentially harmful. In the latent phase, this doesn't occur, and the virus remains undisturbed like a silent piece of genetic code. 98% of the population live symptom free like this.
When the virus spreads lytically, the immune system can see it, as it is outside the cell, and the response will be potentially (most likely) inflammatory. If EBV is the cause of MS, this is likely to be when the 'attacks' occur.
Consequently, if you don't destroy the host cell (as we see with anti-CD20 therapies, for example) then all we are doing is addressing what happens outside the cell, and that may be enough.
Acyclovir and its prodrug, Valacyclovir, cause chain termination because the nucleotide it creates lacks the links to let viral nucleotides attach at the 3rd carbon to continue the chain. Famciclovir doesn't have that attribute, so it can't cause chain termination.
I'm comfortable that I can control my MS by taking 2x500mg per day of valacyclovir, but I don't think for a moment that I can eliminate EBV. All I'm doing is stopping lytic replication, and that is probably enough. I remain well.
Whatever path you choose, the drug needs to cause chain termination of the EBV virus.
Regards,

[DIM]

This is a Facebook group for the Acyclovir/Valacyclovir and their side effects, it seems they have a lot of neurological side effects:
https://www.facebook.com/groups/2403474429948046/

[NHE]

In the US most valacyclovir tablets available are dyed blue with FD&C Blue #2. This dye contains aluminum.

https://pubchem.ncbi.nlm.nih.gov/compou ... minum-lake

Aluminum chloride has been studied in animal models of Alzheimer's Disease going back to 1980.

https://pubmed.ncbi.nlm.nih.gov/?term=% ... _order=asc

It's best to avoid aluminum. There is one manufacturer in the US that doesn't dye their valacyclovir blue. It's made be Mylan Pharmaceuticals.

https://www.drugs.com/imprints/m122-15909.html

~ ~ ~ ~ ~

The above begs the question, given that aluminum has been used to generate the animal model of Alzheimer's Disease for roughly a quarter century, why are the pharmaceutical companies poisoning us?

[Scott1]

Hi Dim,

I looked through that Facebook site. Clearly, there are a range of people with many problems. What is common is they are all asking questions because of their problems, but their issues vary and it's not very clear that all problems are the same. The first questions that comes to my mind is what else are they doing and what else is going wrong? In some cases, I'm not sure that valacyclovir is the right treatment at all.
In 1988, the very gifted scientist, Gertrude Elion (https://www.nobelprize.org/womenwhochan ... rude-elion) won the Nobel prize for medicine or physiology for her work showing acyclovir was a selective antiviral against herpes encephalitis. So, it's been around for a very long time. It is listed by the WHO on their essential medicines list (https://list.essentialmeds.org/recommendations/773 ) The spelling varies as the generic version has an 'i' instead of a 'y'.
NHE is absolutely right in pointing out the Manufacuring process varies across jurisdictions. The tablets I take are all white. I've never taken one with aluminium chloride in it.
I can imagine that some people are experiencing Herximer responses and others may be pushing their uric acid level too high and getting discomfort from that (they don't all have MS on that page).
You need a doctor who understands how it works and what it will do. That can sometimes be difficult to arrange.
Regards,

[DIM]

Hi Scott
Thanks for looking at this Fb page.
Uric acid is not a problem for an MSer, it is too low anyway, the difficult part is to find a friendly doctor who knows how it works to prescribe it.
And even more difficult is to face any adverse reaction especially at the beginning, you know I am very cautious about everything I give to my wife, my "moto" is if you can't do someone good, at least don't harm them!

[Scott1]

Hi Dim,
Yes, you’re correct about Uric acid and MS. However, some of the complaints on the FB page immediately made me think they should be checking their uric acid levels. Most don’t have MS.

[vesta]

Thanks all for your input. My MD is a country Doctor who doesn't want to hear anything contrary to the Medical "authorities" so I'm on my own. She didn't want to hear anything about Ivermectin which as DIM experienced is extremely effective to treat Covid. I'll send you all a private message on the subject since it is a taboo subject. IVN is becominge increasingly difficult to order here in France, maybe all of Europe. I will do everything to keep it in stock. My sister in the USA can still order it so I'll have her deliver it. The CanadIan MD Dr Makis had this to say See private message

However I prefer to keep it as Flu treatment rather than take it to treat EBV.
I was prescribed Valcyclovir for a Shingles "attack" It seemed rather strong, I prefer to keep it as a possible emergency. I asked the MD about the Meds listed above. No response. So for now I'll stick with the "feverfew" mentioned by DIM;
Again, thanks again.

Best regards, Vesta

[DIM]

Can you explain what you mean "it seemed rather strong" please Vesta?
Did you have Herxheimer reaction or what?
Just for your info except the above you mention there are numerous natural compounds against EBV replicaton, say Olive leaf extract, Quercetin, Andrographolide, EGCG, Curcumin, Resveratrol. Luteolin etc, see the chart:

[NHE]

Here's my experience with valacyclovir. I took valacyclovir for two weeks when I found that it had aluminum in it. I decided to finish out the month. I called several pharmacies trying to get the Mylan Pharmaceuticals brand, but I couldn't find one that accepted my insurance. The only side effect I had was that I slept a bit better.

[vesta]

Thanks DIM and NHE. The Shingles crisis (in the eye, terrible headache) occured 9 years ago and I can't really remember why I was relieved to stop taking the valacyclovir as soon as I could. Sorry for the non answer. Thanks DIM for the great chart. I actually have the impression the "feverfew" is helping at the moment, something is.
I couldn't send the personal message to you and Scott1, it kept getting blocked at Preview. Anyway, I just posted it on my site mscureenigmas.net (Maybe NHE can tell me how to get past the Preview??)
Thanks again. Best regards, Vesta

[Scott1]

Hi Vesta,

The size of a valacyclovir dose is also a consideration. The first commercial product was Valtrex and its initial purpose was to treat genital herpes. The dose, at that time, was a short-term high dose (could be multiple tablets a day) that would be over in a week. The Facebook page, that DIM referred to, had a number of posts which looked like they had tried short-term high doses. They were trying to curtail a zoster flare or a herpes sore eruption. Doing that could lead to some people pushing up their uric acid level, and that would be very uncomfortable. A feature of MS patients is low uric acid, so it shouldn't be an issue (but never say never).
The way I use valacyclovir is a low-dose long term application. 2x500mg a day is still low dose. After 11 hours nearly all the valacyclovir from a single tablet has left your system.
If you have coinfections of chronic gamma herpes viridae then valacyclovir will attack all of them. For some people that would make them feel worse, and produce Herximer type reactions. Reducing the dose and persisting would probably work over time but always consult a doctor first.

[vesta]

Thanks Scott. I'll keep your dosage experience in mind. I understand since you began using vacyclovir your MS has disappeared. Could you give a brief resume of your MS experience, or direct me to where you have previously discussed your history?
Best regards, Vesta