Drug effectiveness in doubt.

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vesta
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Drug effectiveness in doubt.

Post by vesta » Sun Oct 26, 2014 2:32 am

On March 21, 2013 it was announced that Professor George C. Ebers, MD, of University of Oxford in London, had been chosen to receive the National MS Society/American Academy of Neurology’s 2013 John Dystel Prize for Multiple Sclerosis. The following quotes come from http://www.nationalmssociety.org site.

QUOTE
"His studies of twins have shown that susceptibility is partly genetic and partly environmental, indicating that MS is a complex genetic disease. These findings contribute to efforts to end MS through prevention. (Proceedings of the National Academy of Sciences U S A 2003;100:12877) This showed linkage to the Human leukocyte antigen (HLA) complex (genes related to the immune system) on chromosome 6. (Lancet 1982;2:88)…
Research is increasingly pointing to reduced levels of vitamin D in the blood as one factor that can increase the risk of developing MS. (Annals of Neurology 2011;70:881)
Delineating the natural history of MS: Dr. Ebers has performed detailed studies tracking over time the “natural history” of MS in London, Ontario, Canada, following more than 1,000 individuals since 1972. Natural history studies provide important knowledge, such as the average number of MS relapses a person may be expected to experience. This helps to appropriately design clinical trials and interpret their results. These studies have been published in a series of important papers on topics such as the predictive value of the early course of MS (Brain 1989;112:1419), and the features of primary progressive MS. (Brain 1999;122:625)…

Epidemiology of MS: Dr. Ebers’ studies have forged new paths our understanding of who gets MS, which is the goal of epidemiology. In a study of over 40,000 people from Canada, Sweden, Norway and the United Kingdom, Dr. Ebers showed that the relative risk of developing MS is higher if you are born in May (like me) and lower if you are born in November. The finding of a birth pattern suggests the possibility that the origins of the disease date to very early in life. (British Medical Journal 2005;330:120)" (My comment. The Sun related Vitamin D deficiency persists throughout growth. For example, people who moved to Sweden from Iran at an average age of 17 developed MS at the higher Scandinavian rate. (Ahlgren et al., 2010).

Dr. Ebers also has contributed to the study of gender differences in MS. Among other contributions, he documented in 2006 a significant increase in the number of women diagnosed with MS more than men, noting that the female to male ratio in the incidence of MS had increased progressively over the previous 50 years. (Lancet Neurology 2006;5:932) (My comment.. The FDA approved Birth Control Pills in 1960. I suspect use of hormonal therapy has triggered the striking increase in female susceptibility to MS, the original male/female ratio being 1:1.)

A series of studies on the relatives of people with MS including spouses, half-siblings, adoptees, and step-siblings suggested the idea that increases in the risk for developing MS come less from the familial environment than from factors operating at a general population level, such as climate and/or diet. These studies led to examination of role of Vitamin D in MS risk and the potential of vitamin D supplementation for MS patients and their families. (Lancet Neurology 2008;7:268)"

END OF QUOTE

The Neurology Community was less pleased with Dr. Ebers when on 17 October 2013 he gave a lecture titled “Critical Review of outcomes used in MS clinical trials” which was posted on You Tube November 4, 2013 by the European Medicines Agency.

Dr. Ebers basically said that current MS medications do NOT prevent descent into Progressive MS disability. See my blog (MS Drug/MRI Fallacy January 5, 2014) DMD’s treat the inflammation of the early RRMS. Once the Progressive stage sets in, they don’t work and decline sets in. Apparently the brain atrophies as do the veins draining the brain. It has been demonstrated that blood transit time in MS patients is one half that of normals. The question is one of perfusion i.e. blood flow, volume and mean transit time. ALL brain fluids contribute to adequate blood flow.

Dr. Ebers has engaged in debates denouncing (politely) the failure of Neurologists to face facts about DMD efficacy, arguing that the CCSVI controversy had revealed to what extent MS patients don’t trust their Doctors. If one obediently follows standard therapy only to finish seriously handicapped, by which time the CCSVI option and/or the “nourish the grey matter” option are less viable, one will have made a mistake. I believe current research delays owing to ideology and vested interests border on criminal.


Joan Beal (cheerleader on Thisisms.com), who oversees treatment for her husband Jeff, has combined the various options by 1) arranging the first Stanford CCSVI MS angioplasty (in his case the Jugulars were opened with stents) 2) using the MS drug Copaxone to prevent relapses and 3) "prescribing" optimal nutrition to nourish the brain's grey matter as well as the veins' epithelium.The Neurology community is still busy denying the viability of the CCSVI option, clinging to the observation that the benefits of Venoplasty disappear over time. So why not find out why and how to fix it?

From MS Cure Enigmas.net

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Kinora
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Re: Drug effectiveness in doubt.

Post by Kinora » Fri Dec 28, 2018 4:30 am

I use a non invasive medical device that increases blood flow to the entire body and brings oxygen to the cells through a engineered specific wave that stimulates the capillaries. It helps me a lot with fatigue and mobility and has helped my quality of life.

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Re: Drug effectiveness in doubt.

Post by ElliotB » Fri Dec 28, 2018 5:03 am

Thanks for reviving this old thread, I had not seen it before. Few studies have been done over a very long period of time like this one. The video is worth watching, not very interesting but very informative and presents a very different perspective on long term outcomes than what is commonly known and thought about the progression of MS.

I share your view about the importance of blood flow. Increased blood flow has been a focus of mine which I accomplish primarily through exercise, hours every day, and through diet and supplements thought to aid and promote increased blood flow as well. I also do oxygen therapy. Only time will tell if this approach is working, so far so good.
Last edited by ElliotB on Wed Jan 02, 2019 5:30 am, edited 1 time in total.

vesta
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Re: Drug effectiveness in doubt.

Post by vesta » Wed Jan 02, 2019 1:50 am

Kinora wrote:I use a non invasive medical device that increases blood flow to the entire body and brings oxygen to the cells through a engineered specific wave that stimulates the capillaries. It helps me a lot with fatigue and mobility and has helped my quality of life.
What is the medical device you refer to and how/where can one obtain it? Thanks for your input.

Best regards, Vesta

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zen2010
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Re: Drug effectiveness in doubt.

Post by zen2010 » Fri Jan 04, 2019 2:41 am

vesta wrote:
Wed Jan 02, 2019 1:50 am
Kinora wrote:I use a non invasive medical device that increases blood flow to the entire body and brings oxygen to the cells through a engineered specific wave that stimulates the capillaries. It helps me a lot with fatigue and mobility and has helped my quality of life.
What is the medical device you refer to and how/where can one obtain it? Thanks for your input.

Best regards, Vesta
Hi Kinora,
I am also interested.
thks

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Re: Drug effectiveness in doubt.

Post by ElliotB » Fri Jan 04, 2019 4:24 am

There are numerous non evasive devices designed to increase blood flow. I too am curious as to which one the OP is using. To find out some of the options currently available, simply do a search for "medical device that increases blood flow" online. There are many such devices. And for additional increased oxygenation, simple, inexpensive home oxygen concentrators can be used. And controlled breathing yoga style can also help increase oxygen levels in the body!

But perhaps the best method is still the old fashioned way, through exercise! Aside from increases in blood flow and oxygen throughout your body, old fashioned exercise has countless benefits, including:
It Can Make You Feel Happier. ...
It Can Help With Weight Loss. ...
It Is Good for Your Muscles and Bones. ...
It Can Increase Your Energy Levels. ...
It Can Reduce Your Risk of Chronic Disease. ...
It Can Help Skin Health. ...
It Can Help Your Brain Health and Memory..

And the good news is that you don't have to exercise strenuously to receive health benefits, even basic walking is a very, very good exercise!

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Re: Drug effectiveness in doubt.

Post by zen2010 » Sun Mar 10, 2019 4:56 am


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