Depleting EBV infected b-cells therapy
Depleting EBV infected b-cells therapy
Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302936/
BACKGROUND. Increasing evidence indicates a role for EBV in the pathogenesis of multiple sclerosis (MS). EBV-infected autoreactive B cells might accumulate in the CNS because of defective cytotoxic CD8+ T cell immunity. We sought to determine the feasibility and safety of treating progressive MS patients with autologous EBV-specific T cell therapy.
METHODS. An open-label phase I trial was designed to treat 5 patients with secondary progressive MS and 5 patients with primary progressive MS with 4 escalating doses of in vitro–expanded autologous EBV-specific T cells targeting EBV nuclear antigen 1, latent membrane protein 1 (LMP1), and LMP2A. Following adoptive immunotherapy, we monitored the patients for safety and clinical responses.
RESULTS. Of the 13 recruited participants, 10 received the full course of T cell therapy. There were no serious adverse events. Seven patients showed improvement, with 6 experiencing both symptomatic and objective neurological improvement, together with a reduction in fatigue, improved quality of life, and, in 3 patients, reduced intrathecal IgG production. All 6 patients receiving T cells with strong EBV reactivity showed clinical improvement, whereas only 1 of the 4 patients receiving T cells with weak EBV reactivity showed improvement (P = 0.033, Fisher’s exact test).
CONCLUSION. EBV-specific adoptive T cell therapy was well tolerated. Clinical improvement following treatment was associated with the potency of EBV-specific reactivity of the administered T cells. Further clinical trials are warranted to determine the efficacy of EBV-specific T cell therapy in MS.
Re: Depleting EBV infected b-cells therapy
Many thanks in advance for advice and comments!
Re: Depleting EBV infected b-cells therapy
I don't think so, except if somebody around here was in the clinical trial. Maybe you can try to contact the researchers to get included in future trials.
-
- Similar Topics
- Replies
- Views
- Last post
-
-
Extrinsic defect in B cells differentiation through alteration of T FH cells
by frodo » Thu Jun 27, 2019 12:58 am » in MS Etiology and Pathogenesis - 0 Replies
- 655 Views
-
Last post by frodo
Thu Jun 27, 2019 12:58 am
-
-
-
anti-CD20 works on B-cells but also on T-cells
by frodo » Wed Aug 19, 2020 4:56 am » in MS Etiology and Pathogenesis - 0 Replies
- 161 Views
-
Last post by frodo
Wed Aug 19, 2020 4:56 am
-
-
- 1 Replies
- 620 Views
-
Last post by jimmylegs
Mon Jun 24, 2019 8:07 am
-
- 4 Replies
- 1900 Views
-
Last post by jimmylegs
Tue Jul 09, 2019 7:26 am
-
- 1 Replies
- 347 Views
-
Last post by Petr75
Thu Oct 01, 2020 9:32 am
-
- 0 Replies
- 283 Views
-
Last post by Petr75
Sat Sep 05, 2020 11:36 am
-
- 0 Replies
- 232 Views
-
Last post by Petr75
Tue Nov 03, 2020 12:07 pm
-
- 0 Replies
- 284 Views
-
Last post by Petr75
Sat Jun 20, 2020 2:24 am
-
-
Experimental therapy against EBV performs well
by frodo » Fri Oct 02, 2020 8:45 am » in General Discussion - 3 Replies
- 565 Views
-
Last post by NHE
Wed Nov 11, 2020 11:55 pm
-