I found this specifial glucosamine (n-acetyl) variety at ultimateglucosamine.com
They have a link of one distributer.
Today I just got two jars of Ultimate Glubosamine (n-acetylglucosamine form) in the mail. The same variety given to those mice. I could not find this ANYWHERE else but the website I mentioned above. This is my first day trying it.
I have mixed one teaspoon (as directed) in my tea tonight (tasted quite good) and have consumed it. The only mild side effect I've noticed thus far is feeling a tiny bit anxious and a little hyper. That is passing now.
I plan on upping my dosage to two teaspoons a day after a week of trying the recommended amount... that is unless I have any adverse effects to this.
I will keep you all posted on this and let you know if I start urinating again LOL!
But seriously, I will keep you posted on my bodies reaction to this and if I see any improvement.
I realize that one person is not exactly a trial study, but I will let you know regardless.
It did say if one is allergic to shelfish to not take it. Thankfully I'm not.
HERE IS THE INFORMATION I FOUND..................website link too http://www.medicalnewstoday.com/articles/70952.php
Glucosamine-Like Supplement Inhibits Multiple Sclerosis, Type 1 Diabetes
Main Category: Multiple Sclerosis News
Article Date: 18 May 2007 - 4:00 PDT
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A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to University of California, Irvine health sciences researchers.
In studies on mice, Dr. Michael Demetriou and colleagues with the UC Irvine Center for Immunology found that N-acetylglucosamine (GlcNAc), which is similar but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that incorrectly direct the immune system to attack specific tissues in the body, such as brain myelin in MS and insulin-producing cells of the pancreas in diabetes. Study results appear on the online version of the Journal of Biological Chemistry.
"This finding shows the potential of using a dietary supplement to help treat autoimmune diseases," said Demetriou, an assistant professor of neurology, and microbiology and molecular genetics. "Most importantly, we understand how this sugar-based supplement inhibits the cells that attack the body, making metabolic therapy a rational approach to prevent or treat these debilitating diseases."
The UC Irvine study defines how metabolic therapy with the sugar GlcNAc and other related nutrients modifies the growth and autoimmune activitiy of T-cells. Virtually all proteins on the surface of cells, including T-cells, are modified with complex sugars of variable lengths and composition. Recent studies have shown that changes in these sugars are often associated with T-cell hyperactivity and autoimmune disease.
In mouse models of both MS and type 1 diabetes, Demetriou and colleages found that GlcNAc prevented this hyperactivity and autoimmune response by increasing sugar modifications to the T-cell proteins. This therapy normalized T-cell function and prevented development of paralysis in MS and high blood glucose levels in type 1 diabetes.
This study comes on the heels of others showing the potential of GlcNAc in humans. One previous clinical study reported that 8 of 12 children with treatment-resistant autoimmune inflammatory bowel disease improved significantly following two years of treatment with GlcNAc. No significant adverse side effects were noted.
"Together, these findings identify metabolic therapy using dietary supplements such as GlcNAc as potential treatments for autoimmune diseases." Demetriou said. "Excitement for this treatment strategy stems from the novel mechanism for affecting T-cell function and autoimmunity and the availability and simplicity of its use. However, additional studies in humans will be required to assess the full potential of this therapeutic approach."
Autoimmune diseases such as MS and type 1 diabetes mellitus result from poorly understood interactions between inherited genetic risk and environmental exposure. MS results in neurological dysfunction, while uncontrolled blood glucose in type 1 diabetes can lead to damage of multiple organs.
Article adapted by Medical News Today from original press release.
Ani Grigorian, Sung-Uk Lee, Wenqiang Tian, I-Ju Chen and Guoyan Gao of UC Irvine and Richard Mendelsohn and James W. Dennis of the Samuel Lunenfeld Research Institute in Toronto participated in the study, which was funded by the National Institutes of Health, the National Multiple Sclerosis Society, the Juvenile Diabetes Research Foundation, the Wadsworth Foundation and the Canadian Institutes for Health Research.
About the University of California, Irvine: The University of California, Irvine is a top-ranked university dedicated to research, scholarship and community service. Founded in 1965, UCI is among the fastest-growing University of California campuses, with more than 25,000 undergraduate and graduate students and about 1,800 faculty members. The second-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3.7 billion. For more UCI news, visit http://www.today.uci.edu/.
Contact: Tom Vasich
University of California - Irvine
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I'd urge some caution about N-A-G...
We've discussed this supplement on the boards before. I had my husband on it (dx MS 3/07), until learning that this supplement is a precursor to hyaluronic acid production- he stopped taking it-
Hyaluronic acid prevents oligodendrocytes from repairing the damaged myelin I was of the impression people with MS may not want more hyaluronic acid. So, I think it's hard to determine if N-A-G might or might not be a good thing.
Please read our thread. Whatever you decide, I wish you health and answers in your search-
As the site's resident "insulin girl" and since these glucosamines are sugar-based supplement, I urge caution in their use. Anything that ramps up insulin secretion is not a good thing for heart disease, diabetes, hypertension, maybe even MS!
read up about mice and NAG
Further investigation revealed that the tremors were associated with the loss of myelin sheaths on nerve cells, very similar to the myelin loss associated with MS and other neurological diseases, as well as in premature infants. In addition, Sherman's lab found large amounts of hyaluronic acid (HA), a carbohydrate, in the brains of these mice. A comparison to brain tissue of deceased human MS patients also revealed heightened levels of HA, apparently caused by the increased presence of CD44 -- something which had never been noted before. It was at this point that Sherman contacted Bebo, who had been studying an MS-like disease in mice for many years, and they began a collaboration to study how HA accumulated in regions of the nervous system where myelin had been destroyed.
"These investigations revealed that oligodendrocytes, which are cells that form myelin in the brain, were prevented from repairing the damaged myelin when there were elevated levels of HA," explained Bebo. "By studying another mouse model in my lab, we made the connection between heightened levels of HA -- specifically a high-molecular weight version of HA -- and myelin loss in an MS-like disease in mice. We also identified the cells that were making the HA and determined that HA accumulation was linked to an overabundance of the CD44 protein."
I'd ride on an extract from shellfish before I ever touch those nasty chemicals again!
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Sorry for any misunderstandings-
No one is poo-pooing glucosamine-
we just wanted to fill you in on this specific form of glucosamine called N-A-G (NAG is not a disease, it's an acronym for n-acetyl glucosamine), because we all look out for each other on these boards, and we were concerned with how this supplement could raise someone's hyaluronic acid.
You're absolutely right- there are plusses and minuses to every single treatment available. Whatever works for you.
"I can't know for sure, but I have to wonder if this stuff is associated with Kim's current exaserbation."
Did she notice any improvement in the beginning of taking it and then got flare ups later?
I've been taking it for two days and have had dramatic improvements, already in my body. I can't begin to describe the level of energy and some normal skin sensation that is coming back.
Not to mention my cognitive response is much sharper and my mood has improved greatly.
I can't see how this stuff can be bad for my MS when I'm already feeling improvement.
It is really a bummer to hear people say that it is a no no when I haven't felt this good in about 5 years.
I'm interested to know your findings with experimenting with the glucosamine in your wife's diet. Please read above.
Sorry to everyone for sounding crabby about this, I'm just finding it hard to believe that something that makes me feel normal and wonderful again is bad for my MS.
my mind doesn't want to ignore these cautions, but my improving body does
This is off topic, but I wanted to mention that there is one supplement that has played hell with my MS in the past. That is vitamin B1 and/or B complex vitamins . Every time I used to take that my hands would go number than numb. I always thought the B vitamins were essential to a healthy nervous system, but that stuff scared the pants off of me.
Kim is off NAG right now. I'm glad to hear that it's working for you. The issue might be about dosage. Kim was taking 750 mg per day.
I'd like to know more about how this is working out for you, what else you are taking and quantities.
I came back to this issue because I wondered about it in relationship to the ABX regimin that Kim is doing now. I'm still not convinced that this is a good idea, but I'd like to know if there is a small group here at TIMS that is seeing benefit from it - following a similar protocol.
One the sidelines, Ken
If I have included a bad link, google the word "Scholar", click link for "Google Scholar". Search for the name of the paper and author in Google Scholar.