all things vitamin D

Discuss herbal therapies, vitamins and minerals, bee stings, etc. here
User avatar
NHE
Volunteer Moderator
Posts: 5375
Joined: Sat Nov 20, 2004 3:00 pm
Contact:

Re: all things vitamin D

Post by NHE » Wed Mar 18, 2020 6:17 am

jimmylegs wrote:
Tue Mar 17, 2020 1:44 pm
new(ish) review, in which i note the following extensively-discussed interaction:

Important drug-micronutrient interactions: A selection for clinical practice (2020)
https://www.ncbi.nlm.nih.gov/pubmed/30580552

"Magnesium supplementation substantially reversed the resistance to vitamin D treatment (de Baaij, Hoenderop, and Bindels 2015; Gröber, Reichrath, and Holick 2015)."
I may have missed something, but that first reference only mentions vitamin D once and not in the context of vitamin D resistance.

Here's a link to the full text. It looks like a good review on magnesium by the way. It just doesn't appear to have much to say about vitamin D.

https://journals.physiology.org/doi/pdf ... 00012.2014

User avatar
jimmylegs
Volunteer Moderator
Posts: 12118
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs » Wed Mar 18, 2020 9:54 am

i imagine the author will have drawn to some degree on both studies to construct the sentence.

on this track at the moment:

Vitamin D3 supplementation and neurofilament light chain in multiple sclerosis (2019)
https://onlinelibrary.wiley.com/doi/abs ... /ane.13185

Abstract
Objectives
Low circulating vitamin D levels are associated with an increased risk of active MRI lesions and relapses in several cohorts with relapsing remitting multiple sclerosis (RRMS). Randomized controlled supplementation trials are, however, negative on their primary endpoints, while secondary MRI endpoints suggest anti‐inflammatory effects. Circulating levels of neurofilament light chain (NfL) are a biomarker of disease activity in RRMS. We explored whether 48‐week high‐dose vitamin D3 supplements were associated with lower circulating NfL levels.

Materials & Methods
Of N = 40 Dutch interferon beta‐treated participants with RRMS of the SOLAR trial, plasma samples at baseline and 48‐week follow‐up were available. Of these participants, N = 24 were supplemented with 14 000 IU/d vitamin D3 and N = 16 with placebo. Twenty‐five hydroxyvitamin D3 (25(OH)D3) levels were measured with LC‐MS/MS, and NfL levels were measured in duplicate with Simoa.

Results
Serum 25(OH)D3 levels at 48 weeks were increased in the vitamin D3 when compared to placebo group (median level 281 [IQR 205‐330] vs 72 [39‐88] nmol/L; P < .01). NfL levels at 48 weeks did not differ between the treatment groups (median level 25.4 [IQR 19.6‐32.2] vs 25.3 [17.9‐30.1] pg/mL; P = .74). Higher week 48 NfL level showed a trend toward association with a higher risk of combined unique active lesions on the week 48 MRI scan (OR 2.39 [95% CI 0.93‐6.12] for each 10 pg/mL increase; P = .07).

Conclusions
Supplementation of high‐dose vitamin D3 for 48 weeks was not associated with lower NfL levels. This study does not support an effect of vitamin D3 on this biomarker of neuro‐axonal injury.

...

4 | DISCUSSION
High-dosed vitamin D3 supplements in interferon beta 1a–treated RRMS did not result in lower plasma NfL levels. This adds to the negative findings of this intervention on clinical endpoints in this study.7
It is also in line with another study, where moderate doses of vitamin D3 supplements did not affect both clinical and NfL endpoints.3,13 These negative results are paralleled by a positive effect of supplements on MRI endpoints.2,7 Therefore, despite these data, vitamin D3 supplementation in RRMS remains a controversial issue
https://www.who.int/news-room/q-a-detail/q-a-coronaviruses

take control of your own health.
pursue optimal self care, with or without a diagnosis.

User avatar
Petr75
Family Elder
Posts: 695
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic

Re: all things vitamin D

Post by Petr75 » Sat Mar 21, 2020 1:20 am

2020 Feb 25
Department of Neuropathology, Institute of Neuropathology, University Medical Center, Göttingen, Germany
High-Dose Vitamin D-Mediated Hypercalcemia as a Potential Risk Factor in Central Nervous System Demyelinating Disease
https://pubmed.ncbi.nlm.nih.gov/32161591/

Abstract

The exact cause of multiple sclerosis (MS) is unknown; however, it is considered to be an inflammatory disease of the central nervous system (CNS) triggered by a combination of both environmental and genetic factors. Vitamin D deficiency is also discussed as a possible disease-promoting factor in MS, as low vitamin D status is associated with increased formation of CNS lesions, elevated number of relapses and accelerated disease progression. However, it remains unclear whether this association is causal and related and most importantly, whether vitamin D supplementation in MS is of direct therapeutic benefit. Recently, we could show that in a murine model of MS, administration of a moderate vitamin D dose was of clinical benefit, while excessive vitamin D supplementation had a negative effect on disease severity. Of note, disease exacerbation was associated with high-dose vitamin D caused secondary hypercalcemia. Mechanistically dissecting this outcome, we found that hypercalcemia independent of vitamin D similarly triggered activation of disease-perpetuating T cells. These findings caution that vitamin D should be supplemented in a controlled and moderate manner in patients with MS and concomitantly highlight calcium as a novel potential MS risk factor by itself. In this review, we will summarize the current evidence from animal and clinical studies aiming to assess whether vitamin D may be of benefit in patients with MS. Furthermore, we will discuss any possible secondary effects of vitamin D with a particular focus on the role of calcium on immune cells and in the pathogenesis of CNS demyelinating disease.


User avatar
jimmylegs
Volunteer Moderator
Posts: 12118
Joined: Sat Mar 11, 2006 3:00 pm

Re: all things vitamin D

Post by jimmylegs » Sat Mar 21, 2020 6:24 am

good find. i am still impatient for more research that considers d3 interactions with MAGNESIUM :)
https://www.who.int/news-room/q-a-detail/q-a-coronaviruses

take control of your own health.
pursue optimal self care, with or without a diagnosis.

Post Reply
  • Similar Topics
    Replies
    Views
    Last post