COVID nutrition research

[jimmylegs]

preprint: Evidence Supports a Causal Role for Vitamin D Status in COVID-19 Outcomes (Jun 13)
https://www.medrxiv.org/content/10.1101 ... 20087965v3

...Conclusions: Our novel causal inference analysis of global data verifies that vitamin D status plays a key role in COVID-19 outcomes. The data set size, supporting historical, biomolecular, and emerging clinical research evidence altogether suggest that a very high level of confidence is justified. Vitamin D prophylaxis potentially offers a widely available, low-risk, highly-scalable, and cost-effective pandemic management strategy including the mitigation of local outbreaks and a second wave. Timely implementation of vitamin D supplementation programmes worldwide is critical with initial priority given to those who are at the highest risk, including the elderly, immobile, homebound, BAME and healthcare professionals. Population-wide vitamin D sufficiency could also prevent seasonal respiratory epidemics, decrease our dependence on pharmaceutical solutions, reduce hospitalisations, and thus greatly lower healthcare costs while significantly increasing quality of life.

[jimmylegs]

Zinc as nutritional intervention and prevention measure for COVID–19 disease (Jun 17)
https://nutrition.bmj.com/content/early ... 020-000095

Abstract
The present spread of severe acute respiratory syndrome coronavirus 2, provoking COVID–19 disease, progresses rapidly worldwide. In current absence of a curative treatment and an effective, safe vaccine, there is a pressing need to focus on identifying and correcting deficits in immune function in order to reduce risk of severe progress of the disease and to lower the number of infections and fatalities. This paper evaluates the most recent literature on zinc status related to antiviral immunity and its possible role in COVID–19. It is concluded that zinc is a critical factor for antiviral immunity. There is ample evidence suggesting that zinc depletion, also prevalent in high–income nations, compromises immune functions. Notably, major risk groups for COVID–19, the elderly, men more than women, obese individuals and patients with diabetes are all at risk of zinc deficiency. Moreover, various widely used antihypertensive drugs and statin therapy have been reported to negatively influence zinc status. As zinc depletion impairs antiviral immunity, it is hypothesised to increase susceptibility for COVID–19. Therefore, dietary preventive measures and prompt implementation of zinc supplementation for risk groups should be considered. Large–scale studies are urgently needed to investigate the role of micronutrients and antiviral immunity, in particular drug–micronutrient immunity interaction.

[jimmylegs]

preprint: COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study (Jul 3)
https://www.preprints.org/manuscript/202007.0025/v1

related critique:
www.reddit.com/r/COVID19/comments/hkgj7 ... tratified/

[vesta]

preprint: COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study (Jul 3)
https://www.preprints.org/manuscript/202007.0025/v1

related critique:
www.reddit.com/r/COVID19/comments/hkgj7 ... tratified/

Thanks for finding and posting this.
At present in France Doctors are forbidden to treat Covid 19 with HCQ even though it was an over the counter Medication until mid January. My local country Doctor was very fearful to counter the medical authorities on this matter and Dr Raoult who does treat with HCQ is treated like a pariah. Basically she is ordered to withhold treatment and if I begin to have difficulty breathing, she can send me to the hospital (to die). (She didn't want to hear this.) In the meantime the EU has authorized Remdesivir for hospitalized recovery (Gilead product, US price to be over $3,000 HCQ treatment $20.) The various trials (RECOVERY/ SOLIDARITY/DISCOVERY) do specify studying HCQ for hospitalized patients which is NOT recommended use, so of course it is ineffective. Rather, HCQ should be used on an outpatient basis within 5 days of symptom appearance while the virus is still in the throat. Hospitalization unnecessary. (It is beyond me why cost conscious national health countries should favor the exorbitant cost of intubation - one million dollars in the US) Apparently there is a drive to universal vaccination, but why get a vaccine when an effective, cheap treatment is available.
The RECOVERY trial (WHO, Gates Foundation etc) demonstrates that one is willing to kill the patient in order to discredit HCQ; Zelenko/Raoult dose 400 mg a day (Raoult 600 mg first day), RECOVERY trial 2,400 mg in first 24 hours.
It is frightening to live in a country where powerful interests forbid effective, non toxic treatment.

[jimmylegs]

posted in the natural approach section for the zinc content.

obviously tough to find a COVID study in which an essential nutrient isn't combined with something else, if used at all.

there are other spaces at TiMS to discuss the merit, or lack thereof, of available pharmaceutical trials.

[jimmylegs]

observational, but i will still be interested in these results once they become available

Evaluation of the Relationship Between Zinc Vitamin D and b12 Levels in the Covid-19 Positive Pregnant Women (last update June 23)
https://clinicaltrials.gov/ct2/show/NCT ... w=3&rank=4

[jimmylegs]

interventional, but could be better designed. open label is not the best, obviously. also, i've recently been looking at zinc forms and don't have a great impression of zinc gluconate bioavailability.

Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation (COVIDAtoZ) (last update May 14)
https://clinicaltrials.gov/ct2/show/NCT ... w=2&rank=5