Statins have detrimental effects on remyelination in MS
Statins have detrimental effects on remyelination in MS
Simvastatin interferes with process outgrowth and branching of oligodendrocytes.
Abstract
Statins have attracted interest as a treatment option for multiple sclerosis (MS) because of their pleiotropic antiinflammatory and immunomodulatory effects.
However, contradictory results have been described when they are applied to oligodendrocytes (OLGs), the cell type predominantly affected in MS. In this study we focus on the in vitro effect of statins on process outgrowth in OLN-93 cells, a well-characterized OLG-derived cell line, and primary cultures of neonatal rat OLGs. ... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1319
MS-UK - http://www.ms-uk.org/
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 2078 Views
-
Last post by NHE
-
- 1 Replies
- 3497 Views
-
Last post by ElliotB
-
- 0 Replies
- 1050 Views
-
Last post by jimmylegs
-
- 0 Replies
- 988 Views
-
Last post by frodo
-
- 0 Replies
- 1204 Views
-
Last post by DIM
-
- 0 Replies
- 1045 Views
-
Last post by frodo
-
- 0 Replies
- 1217 Views
-
Last post by NHE
-
- 0 Replies
- 1312 Views
-
Last post by DIM
-
- 1 Replies
- 2731 Views
-
Last post by Tif