Dosage?
Dosage?
I found this article online and was wondering if the dosage is similar.
The objective of this case report is to document the possibility that immunoablative doses of cyclophosphamide may provide a long-term remission of multiple sclerosis (MS). We report the case of a 48-year-old woman with definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of cyclophosphamide was accidentally given intravenously in early 1997. For 7 years there have been no signs of disease activity on history, physical examination, or on high-quality magnetic resonance imaging (MRI) with appropriate contrast-enhancement methodology.
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Lyon wrote:LR1234 wrote: To make matters even harder to keep track of, Dr Gladstone had been affiliated with JH at one time and then was doing HDC studies with Stonybrook. The JH research we're familiar with and evidently U of Chicago was/is/is going to do HDC research....as Revimmune?? I don't know.
I find it interesting by any name, but I wish I had a better grasp!
Bob
And for yet another wrinkle... Dr. Gladstone is back at JH
I don't know how involved he is with any MS trials though.
Chris,
Any idea why the dosage is calculated using ideal vs actual body weight?
FWIW, I admit I've gone with the ask forgiveness rather than permission paradigm more than once myself.

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Re: Dosage
3800 mg would be about one day's worth of the Revimmune protocol. For a 150 lb. person they would receive about 3400 mg/day when being treated with Revimmune.Lyon wrote:I'm not good with math, but looking at the usual mg per kg, 3800 mg doesn't seem to be much of an "overdose"??
NHE
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