http://eprints-phd.biblio.unitn.it/2974/1/Thesis.pdfOur computational results show that during the cardiac cycle there is an intraparenchymal
bidirectional CSF-ISF movement which potentially helps to avoid localizations of stagnant water
inside the brain. Based on the computational results, we propose that glymphatic system results
from the following dynamics: 1) intraparenchymal bidirectional ISF-CSF movement induced by the
Monro-Kellie hypothesis, 2) CSF drainage into the venous and lymphatic systems, 3) intracranial
Starling forces. We also show that cerebral venous outflow decreases the ISF production and
CSF turnover, potentially decreasing the brain-waste clearance and leading to accumulation of
neurotoxins in the parenchyma.
It fits with the idea that the healthier we live, the fewer neurotoxins we'll have circulating in our blood and getting deposited in our brains. It also fits with the idea that improving cerebral venous outflow has a number of positive effects, including the improvement of brain-waste clearance. There was also a suggestion a few years ago that CCSVI could be proven through mathematical models and physics papers, so I am still interested in seeing that angle pan out.