https://www.frontiersin.org/articles/10 ... 5/abstract
In multiple sclerosis (MS), a key role of both coagulation and vascular thrombosis has been reported since the first descriptions of the disease. Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of clinical signs in experimental allergic encephalitis (EAE), an animal model of MS, led to numerous studies to investigate the role of thrombin and fibrin(ogen). Most findings supported that both human and animal disease exacerbation is a condition characterized by an increased coagulation activity. Indeed, the activation of microglia, resident innate immune cells, occurs early after fibrinogen leakage already in pre-demyelinating lesion stage in EAE and MS.
Finally, it has been proven that the use of several anticoagulant agents can successfully improve EAE. Altogether, these studies highlight the role of the coagulation pathway in the pathophysiology of MS and suggest possible therapeutic targets that may complement existing treatments.
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Karpińska, E., Socha, K., Soroczyńska, J., Kochanowicz, J., Jakoniuk, M., Mariak, Z., & Borawska, M. H. (2017). Concentration of magnesium in the serum and the ability status of patients with relapsing-remitting multiple sclerosis. J Elementol, 22(2), 671-9.
re QC and fwiw, except for the last study above, my inst subscribes to all of the journals listed above
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!
Thanks for posting this! I also read today that there is some evidence that aspirin (a blood thinner) may help with MS.
https://www.alzforum.org/news/research- ... erosis-bay
I do really like the idea of optimizing naturally occurring vitamins though, aspirin has risks as well as benefits.
Disclaimer: I'm not recommending any particular course of action. People need to make their own treatment decisions with the help of their medical advisors.
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