Coagulation dysfunction in multiple sclerosis

[frodo]

A perspective of Coagulation dysfunction in multiple sclerosis and in EAE

https://www.frontiersin.org/articles/10 ... 5/abstract

In multiple sclerosis (MS), a key role of both coagulation and vascular thrombosis has been reported since the first descriptions of the disease. Subsequently, the observation of a close concordance between perivascular fibrin(ogen) deposition and the occurrence of clinical signs in experimental allergic encephalitis (EAE), an animal model of MS, led to numerous studies to investigate the role of thrombin and fibrin(ogen). Most findings supported that both human and animal disease exacerbation is a condition characterized by an increased coagulation activity. Indeed, the activation of microglia, resident innate immune cells, occurs early after fibrinogen leakage already in pre-demyelinating lesion stage in EAE and MS.

Finally, it has been proven that the use of several anticoagulant agents can successfully improve EAE. Altogether, these studies highlight the role of the coagulation pathway in the pathophysiology of MS and suggest possible therapeutic targets that may complement existing treatments.

[jimmylegs]

related:

Fong, J. S. C. (1976). Alpha-tocopherol: its inhibition on human platelet aggregation. Experientia, 32(5), 639-641.

Saldeen, T., Li, D., & Mehta, J. L. (1999). Differential effects of α-and γ-tocopherol on low-density lipoprotein oxidation, superoxide activity, platelet aggregation and arterial thrombogenesis. Journal of the American College of Cardiology, 34(4), 1208-1215.

Freedman, J. E., & Keaney Jr, J. F. (2001). Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. The Journal of nutrition, 131(2), 374S-377S.

Liu, M., Wallmon, A., Olsson-Mortlock, C., Wallin, R., & Saldeen, T. (2003). Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. The American journal of clinical nutrition, 77(3), 700-706.

Jiménez-Jiménez, F. J., de Bustos, F., Molina, J. A., de Andrés, C., Gasalla, T., Ortı́-Pareja, M., ... & de Salamanca, R. E. (1998). Cerebrospinal fluid levels of alpha-tocopherol in patients with multiple sclerosis. Neuroscience Letters, 249(1), 65-67.

Besler, H. T., Çomoğlu, S., & OkÇu, Z. (2002). Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutritional neuroscience, 5(3), 215-220.


Shechter, M., Merz, C. N. B., Paul-Labrador, M., Meisel, S. R., Rude, R. K., Molloy, M. D., ... & Kaul, S. (1999). Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. The American journal of cardiology, 84(2), 152-156.

Kh, R., Khullar, M., Kashyap, M., Pandhi, P., & Uppal, R. (2000). Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. Journal of hypertension, 18(7), 919-925.

Shechter, M., Merz, C. N. B., Rude, R. K., Labrador, M. J. P., Meisel, S. R., Shah, P. K., & Kaul, S. (2000). Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease. American heart journal, 140(2), 212-218.

Yasui, M., Yase, Y., Ando, K., Adachi, K., Mukoyama, M., & Ohsugi, K. (1990). Magnesium concentration in brains from multiple sclerosis patients. Acta neurologica scandinavica, 81(3), 197-200.

Karpińska, E., Socha, K., Soroczyńska, J., Kochanowicz, J., Jakoniuk, M., Mariak, Z., & Borawska, M. H. (2017). Concentration of magnesium in the serum and the ability status of patients with relapsing-remitting multiple sclerosis. J Elementol, 22(2), 671-9.

re QC and fwiw, except for the last study above, my inst subscribes to all of the journals listed above

[ThisIsMA]

Hi Jimmilegs,

Thanks for posting this! I also read today that there is some evidence that aspirin (a blood thinner) may help with MS.

https://www.alzforum.org/news/research- ... erosis-bay

I do really like the idea of optimizing naturally occurring vitamins though, aspirin has risks as well as benefits.

Disclaimer: I'm not recommending any particular course of action. People need to make their own treatment decisions with the help of their medical advisors.