hi again, i was thinking of a couple folks i'd met years back, who had happened to be on PPIs and just randomly broke their legs - both while simply walking. completely separate and unrelated incidents with only ppis and fracture in common other than both of them being middle-aged guys. at the time, i definitely wondered if mag depletion from the PPI use had been a factor in their injuries.
around here, the mag 'normal' range at the lab can go down as far as 1.7, I've heard of 1.5 being used for the lower end. meanwhile, in this study the group with the highest fracture risk had levels as high as 1.9.
Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved
"...A meta-analysis of nine studies with 115,455 patients by Cegla et al. demonstrated a risk of hypomagnesemia among patients using PPIs ... Since hypomagnesemia is not readily identifiable on regular blood testing, many patients might develop this condition unknowingly."
hopefully fractures aren't on the list of issues you have had - or may have - to deal with!
i went back to the beginning of your first post and am pleased to report that you could reasonably expect using magnesium to give you some relief from "severe leg muscle spasms/Charlie horses"
i'll save you the learning curve i faced years ago and recommend testing out magnesium glycinate. even though mag glycinate is the most readily absorbed, the more you take the more laxative it can be. you could test it at 100 - 200mg per day to see how your system reacts. from there, you could increase to as much as 400mg per day, but carefully.
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