Drug succeeds in trial

Biotin is an emerging therapy for the treatment of secondary progressive MS.
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Drug succeeds in trial

Post by MSUK » Fri Apr 17, 2015 5:27 am

An experimental drug comprising of a high-dose formulation of the food additive biotin has successfully helped patients with primary and secondary progressive MS in a major clinical trial, its French maker claims..... Read More - http://www.ms-uk.org/emergingtherapies
MS-UK - http://www.ms-uk.org/

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Re: Drug succeeds in trial

Post by 1eye » Fri Apr 17, 2015 3:28 pm

As can be seen from the first post in this topic, there has been a phase III trial of a dosage of a substance called biotin, on so-called primary progressive and secondary progressive MS patients. This trial had end points showing an improvement in disability and a halt of disease progression, which is a hallmark of the so-called progressive variant of the disease. In this trial one result has been that 90% of subjects had improvements in their disabilities. That fact alone should result in fast-tracked approval, of the dosage and regimen used in the trial, for patients with progressive MS at least, by Health Canada, and the US FDA. This is not an unknown drug.

I have maintained and still maintain that this disease is not different in cause or likelihood of successful treatment with any specific medicine or procedure, regardless of what course or variation it has been deemed to be, whether primary progressive, secondary progressive, relapsing-remitting, clinically isolated syndrome, benign, or the form known as Marburg, or any other.

The likelihood of any patient, with any form of MS, worsening and having a more progressive course, is very high.

Compared to men, women have a higher likelihood of getting MS. Compared to unrelated people, first-degree relatives of people who have MS have a much higher likelihood of getting MS.

Therefore patients who have any form of MS, who have been diagnosed for any length of time, regardless of age, sex, or any health factors, must have equal access to treatment, with the same dosage and regimen, of biotin, as any other patient, at the same price.

If by careful experiment and analysis, these treatments, with biotin, of a specific sub-group of patients are found retrospectively not to have had the same benefit, their treatment with biotin should not be reduced, as the drug cannot be proven to have no future possibility of benefit, and may in fact be an effective preventative treatment.

The burden of absolute proof, that any individual patient will NOT benefit from treatment with biotin, must be left to the insurer, the government or whoever is expected to pay for the treatment. Acceptance of that proof must remain a matter to be resolved between an individual and their chosen physician. The default must be to assume a patient will benefit, except in the unlikely event that biotin has any negative effect, in an individual case.

The expected efficacy of treatment with biotin must NOT be assessed using statistical analysis. Efficacy must be expected, unless and until proven otherwise. In any case of any form of MS, time is of the essence. A treatment that works in general, in scientific trials, for a later stage or worse form of the disease, must be assumed to work as well or better, for the earlier or less severe, unless and until proven otherwise, in scientific trials or case by case.

It should be an immediate goal to determine the likelihood of biotin treatment being a preventative, for early, suspected, and statistically at-risk groups, from getting MS.
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Re: Drug succeeds in trial

Post by ElliotB » Thu May 21, 2015 1:54 pm

Biotin is not a drug, but rather a vitamin (vitamin H). The results are not necessarily a surprise as Biotin helps break down certain substances like fats, carbohydrates, and others and gives the body increased energy by turning food into energy for the body.

Limited foods like some fishes such as sardines, salmon, and other saltwater fishes are biotin rich foods. Many meats such as beef, turkey, pork, and other red meats contain high amount of biotin. Nuts, root vegetables, and eggs are other good sources of biotin.

Even tofu, mushrooms, and many types of seeds can be biotin-rich, along with milk and cheese.

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