Ocrevus is a Wonder Drug for MS

Discuss Ocrelizumab, a monoclonal antibody treatment for MS.
Post Reply
User avatar
seeva
Family Elder
Posts: 490
Joined: 11 years ago
Location: SYDNEY
Contact:

Ocrevus is a Wonder Drug for MS

Post by seeva » 11 months ago

HI Friends please read a news today1st of feb SMH newspaper news
http://www.smh.com.au/federal-politics/ ... 4yz4v.html
regards
seeva

dansmail26
Newbie
Posts: 5
Joined: 9 months ago

Re: Ocrevus is a Wonder Drug for MS

Post by dansmail26 » 9 months ago

but is it any better then rituximab? My doc wants me to go on rituximab and keep taking avonex as the insurance company wuill keep paying for both.

ElliotB
Family Elder
Posts: 1687
Joined: 5 years ago
Been thanked: 1 time

Re: Ocrevus is a Wonder Drug for MS

Post by ElliotB » 9 months ago

per the article:

"....A few months later she is "99 per cent back to normal"

Isn't that the case for most with RRMS whether they take drugs of any kind or not? How do they know with certainty it was the Ocrevus?

User avatar
NHE
Volunteer Moderator
Posts: 5018
Joined: 14 years ago
Contact:

Re: Ocrevus is a Wonder Drug for MS

Post by NHE » 9 months ago

ElliotB wrote:per the article:

"....A few months later she is "99 per cent back to normal"

Isn't that the case for most with RRMS whether they take drugs of any kind or not? How do they know with certainty it was the Ocrevus?
N's of one may or may not be interesting, but they're certainly meaningless statistically.

undisclosED
Newbie
Posts: 6
Joined: 3 years ago

Re: Ocrevus is a Wonder Drug for MS

Post by undisclosED » 8 months ago

If anyone is interested, there is a new, closed Facebook group that was started on April 13, 2018 specifically for PPMS, SPMS and Ocrevus.

https://www.facebook.com/groups/152024362299714/

Kheuer
Getting to Know You...
Posts: 21
Joined: 2 months ago

Re: Ocrevus is a Wonder Drug for MS

Post by Kheuer » 2 months ago

Based on all the continually emerging data, I agree, wonder drug. First infusions 1 month post diagnosis.

New results from clinical studies show ocrevus results in some patients

RECOVERING LOST FUNCTION

Kheuer
Getting to Know You...
Posts: 21
Joined: 2 months ago

Re: Ocrevus is a Wonder Drug for MS

Post by Kheuer » 1 month ago

dansmail26 wrote:but is it any better then rituximab? My doc wants me to go on rituximab and keep taking avonex as the insurance company wuill keep paying for both.
Short answer = yes

Long answer =

1. It is 100% human versus the human/mouse chimeric rituxan

2. It has a higher binding affinity for CD20 expressing b cells than rituxan, and a lower affinity for non CD20 b cells --> binds more preferentially to the bad B cells than rituxan, and less to the non bad B cells

4. It has a higher efficacy at causing cell death than rituxan, it binds at different epitopes on the cell causing more efficient cell death

5. It has been clinically shown to STOP progression in some patients after 2 years of infusions.

6. It has been clinically proven to actually help some patients RECOVER LOST COGNITIVE AND PHYSICAL FUNCTION after 4 years.

It is the ONLY THERAPY to ever do #5 and #6

ElliotB
Family Elder
Posts: 1687
Joined: 5 years ago
Been thanked: 1 time

Re: Ocrevus is a Wonder Drug for MS

Post by ElliotB » 1 month ago

"It is the ONLY THERAPY to ever do #5 and #6"

Not true - there are now other safe therapies doing #5 and #6.

Kheuer
Getting to Know You...
Posts: 21
Joined: 2 months ago

Re: Ocrevus is a Wonder Drug for MS

Post by Kheuer » 6 days ago

ElliotB wrote:
1 month ago
"It is the ONLY THERAPY to ever do #5 and #6"

Not true - there are now other safe therapies doing #5 and #6.
Which clinically documented? Because you're statement is factually incorrect.

Ocrevus is the ONLY treatment to stop progression and also recover LOST function, unless you are talking the Klenner Protocol, which I believe to be effective, yet was not clinically documented.

I use a modified oral Klenner Protocol as adjuvant to Ocrevus.

If you did the full Klenner Protocol -- including the IM and IV doses, the cost approaches 50k+. The compounding RX for shots and IV is expensive.

The Wahl protocol has no clinical evidence to date.

FYI Genentech puts your entire out if pocket Ocrevus plus infusion clinic cost onto a debit card that YOU pay your DR with. It is essentially free and also wipes out your out of pocket max, so all your other medical care is free for the year if you get an infusion early. I'm sitting in a recliner 2 hours into my 6 hour ride right now.

ElliotB
Family Elder
Posts: 1687
Joined: 5 years ago
Been thanked: 1 time

Re: Ocrevus is a Wonder Drug for MS

Post by ElliotB » 6 days ago

"5. It has been clinically shown to STOP progression in some patients after 2 years of infusions."

in some patients?

FACT: The progression in some patients stops without any intervention of any kind. This is the case for the majority of those with MS.


Clinical trials are easy to add bias, all too easy to manipulate, to get a desired outcome. And of course interpretation of the results can also be manipulated/biased depending on what the desired conclusion is.


Copaxone is thought to reduce the rate of relapses and to slow the progression of MS as well and there have been many clinical trials on that drug.

And of course there are numerous non-'proven' protocols.


The true fact is there is no way of knowing that any of these drugs and protocols really work. How can you really know for sure with a disease that by its nature goes into remission for most and is totally unpredictable.

Post Reply
  • Similar Topics
    Replies
    Views
    Last post