Reactivation of Hepatitis B Virus

Discuss Ocrelizumab, a monoclonal antibody treatment for MS.
Post Reply
User avatar
Family Elder
Posts: 1125
Joined: Sat Oct 19, 2013 10:17 am
Location: Czech Republic

Reactivation of Hepatitis B Virus

Post by Petr75 » Mon Feb 25, 2019 10:12 am

2018 Dec 26
Department of Public Health and Infectious Diseases, Sapienza, University of Rome, Rome, Italy
Reactivation of Hepatitis B Virus With Immune-Escape Mutations After Ocrelizumab Treatment for Multiple Sclerosis

Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS) that is closely related to rituximab. We describe a case of hepatitis B virus (HBV) reactivation in an MS patient with resolved HBV infection receiving ocrelizumab. HBV reactivation was monitored with HBV-DNA and HBV surface antigen periodic assessment. Anti-HBV treatment with entecavir was started after HBV-DNA detection. Ocrelizumab can reactivate viral replication in patients with resolved HBV infection. HBV reactivation monitoring seems an effective and safe option for the management of these patients. More studies are needed to assess the optimal management of HBV reactivation in MS patients on ocrelizumab treatment.

Post Reply
  • Similar Topics
    Last post

Return to “Ocrevus (Ocrelizumab)”