MS also affects peripheral nervous system

[frodo]

MRN - Magnetic resonance neurography - shows damage in peripheral nerves of MS patients. This is not explained by any of the currently accepted theories, and therefore it is expected that it will open new ways to understand the disease.

Peripheral nerve involvement in multiple sclerosis Demonstration by magnetic resonance neurography

http://onlinelibrary.wiley.com/doi/10.1 ... 8/abstract

Objective:To detect and quantify peripheral nerve lesions in multiple sclerosis (MS) by magnetic resonance neurography (MRN).

Interpretation: Peripheral nerve lesions could be visualized and quantified in MS in vivo by high resolution MRN. Lesions are defined by an increase of proton-spin-density and a decrease of T2-relaxation time, indicating changes in the microstructural organization of the extracellular matrix in peripheral nerve tissue in MS. By showing involvement of the peripheral nervous system in MS, this proof-of-concept study may offer new insights into the pathophysiology and treatment of MS.