review from Hans Lassman

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frodo
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review from Hans Lassman

Post by frodo » Wed Jan 24, 2018 11:00 am

Hans Lassman is one of the leaders in MS research. He does not say the word "autoimmune" anymore, nor speaks too much about myelin.

Multiple Sclerosis Pathology.

https://www.ncbi.nlm.nih.gov/pubmed/29358320

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to diffuse neurodegeneration in the entire brain. In this review, the spectrum of MS lesions and their relation to the inflammatory process is described.

Pathology suggests that inflammation drives tissue injury at all stages of the disease. Focal inflammatory infiltrates in the meninges and the perivascular spaces appear to produce soluble factors, which induce demyelination or neurodegeneration either directly or indirectly through microglia activation. The nature of these soluble factors, which are responsible for demyelinating activity in sera and cerebrospinal fluid of the patients, is currently undefined. Demyelination and neurodegeneration is finally accomplished by oxidative injury and mitochondrial damage leading to a state of "virtual hypoxia."

vesta
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Re: review from Hans Lassman

Post by vesta » Thu Jan 25, 2018 7:14 am

frodo wrote:Hans Lassman is one of the leaders in MS research. He does not say the word "autoimmune" anymore, nor speaks too much about myelin.

Multiple Sclerosis Pathology.

https://www.ncbi.nlm.nih.gov/pubmed/29358320

Abstract

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to diffuse neurodegeneration in the entire brain. In this review, the spectrum of MS lesions and their relation to the inflammatory process is described.

Pathology suggests that inflammation drives tissue injury at all stages of the disease. Focal inflammatory infiltrates in the meninges and the perivascular spaces appear to produce soluble factors, which induce demyelination or neurodegeneration either directly or indirectly through microglia activation. The nature of these soluble factors, which are responsible for demyelinating activity in sera and cerebrospinal fluid of the patients, is currently undefined. Demyelination and neurodegeneration is finally accomplished by oxidative injury and mitochondrial damage leading to a state of "virtual hypoxia."
"soluble factors" like in venous blood for example???

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frodo
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Re: review from Hans Lassman

Post by frodo » Wed Jan 31, 2018 8:42 am

vesta wrote: "soluble factors" like in venous blood for example???
I would say that they have in mind something neurotoxic in the CNS ... We will have to wait for a complete answer.

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