Biomarkers: LOTUS in CSF

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Biomarkers: LOTUS in CSF

Post by frodo » Fri Feb 23, 2018 2:14 am

LOTUS (lateral olfactory tract usher substance) could be used as biomarker for inflammation:

Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation

https://jneuroinflammation.biomedcentra ... 018-1084-x


CSF levels of LOTUS correlated inversely with disease activity in both bacterial and viral meningitis, as well as in multiple sclerosis, because neuroinflammation downregulated LOTUS expression. Our data strongly suggest that variation of CSF LOTUS is associated with neuroinflammation and is useful as a biomarker for a broader range of neuroinflammatory diseases.

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