Biomarkers: LOTUS in CSF

A forum to discuss research on the origins of MS and its development.
Post Reply
User avatar
frodo
Family Elder
Posts: 1782
Joined: Wed Dec 02, 2009 3:00 pm
Contact:
Contact frodo

Biomarkers: LOTUS in CSF

Post by frodo »

LOTUS (lateral olfactory tract usher substance) could be used as biomarker for inflammation:

Cerebrospinal fluid level of Nogo receptor 1 antagonist lateral olfactory tract usher substance (LOTUS) correlates inversely with the extent of neuroinflammation

https://jneuroinflammation.biomedcentra ... 018-1084-x



Conclusions

CSF levels of LOTUS correlated inversely with disease activity in both bacterial and viral meningitis, as well as in multiple sclerosis, because neuroinflammation downregulated LOTUS expression. Our data strongly suggest that variation of CSF LOTUS is associated with neuroinflammation and is useful as a biomarker for a broader range of neuroinflammatory diseases.
Top
Post Reply

Return to “MS Etiology and Pathogenesis”