several types of alterations in NAWM and NAGM

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frodo
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several types of alterations in NAWM and NAGM

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Exploring metabolite profiling of patients with secondary progressive multiple sclerosis

http://discovery.ucl.ac.uk/10043414/1/M ... t%20al.pdf


Synopsis

Proton magnetic resonance spectroscopic imaging (MRSI) quantifies brain metabolism in vivo and has the potential of uncovering the mechanism of action of therapeutic drugs.

In this study, we assessed the baseline metabolic profile of 161 patients with secondary progressive multiple sclerosis (SPMS) against a control population by applying a short TE PRESS MRSI protocol at 3T.

Based on the results the SPMS population could be divided into different groups (normal/biochemically abnormal) suggesting biochemical heterogeneity within SPMS patients
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