Nfl increases BEFORE damage appears on MRI
Nfl increases BEFORE damage appears on MRI
Neurofilament light chain as an indicator of exacerbation prior to clinical symptoms in multiple sclerosis
https://www.sciencedirect.com/science/a ... 481930135X
Highlights
• CSF NfL increase is significantly elevated and precedes clinical symptoms by many weeks.
• CSF NfL increase correlates with clinical symptoms despite no change in MRI suggesting more sensitive and relevant biomarker for an exacerbation than MRI.
• CSF NfL returns to baseline consistent with clinical improvement.
• Although baseline CSF NfL is elevated as can be found in patient's age group, it is a reliable marker when use as the individual patients own baseline.
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