MS linked to lipids dysregulation
MS linked to lipids dysregulation
https://en.wikipedia.org/wiki/Eicosanoid
Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction
http://www.haematologica.org/content/ea ... 019.219519
Abstract
Chronic inflammation is a key pathological hallmark of multiple sclerosis and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators, is impaired.
Here, through targeted-metabololipidomics in peripheral blood of patients with multiple sclerosis, we revealed that each disease form was associated with distinct lipid mediator profiles that significantly correlated with disease severity.
In particular, relapsing and progressive multiple sclerosis patients were associated with high eicosanoids levels, whereas the majority of pro-resolving lipid mediators were significantly reduced or below limits of detection and correlated with disease progression.
Furthermore, we found impaired expression of several pro-resolving lipid mediators biosynthetic enzymes and receptors in blood-derived leukocytes of MS patients.
Mechanistically, differentially expressed mediators like LXA4, LXB4, RvD1 and PD1 reduced multiple sclerosis-derived monocyte activation and cytokine production and inhibited inflammation-induced blood-brain barrier dysfunction and monocyte transendothelial migration.
Altogether, these findings reveal peripheral defects in the resolution pathway in multiple sclerosis, suggesting pro-resolving lipid mediators as novel diagnostic biomarkers and potentially safe therapeutics.
-
- Family Elder
- Posts: 1159
- Joined: Tue Oct 09, 2012 6:33 am
Re: MS linked to lipids dysregulation
There are so many recently released studies on proresolving mediators but this one from 2008 inspired me to just say no to the supplement.
Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.
https://www.ncbi.nlm.nih.gov/m/pubmed/2271180/
Maybe our abnormal levels of proresolving mediators are protective??? Another concern is the supplements don’t tell you what form of the mediators you are getting. They each have different effects, so it kind of matters. I think i’ll stick w plain ol’ EFA supplements for now.
Has anyone here tried the supplements??
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 189 Views
-
Last post by Petr75
Sat Jul 04, 2020 10:17 pm
-
- 0 Replies
- 560 Views
-
Last post by frodo
Tue Jun 25, 2019 7:18 am
-
-
lipids differentiate PPMS and SPMS
by frodo » Fri Oct 02, 2020 4:47 am » in MS Etiology and Pathogenesis - 0 Replies
- 268 Views
-
Last post by frodo
Fri Oct 02, 2020 4:47 am
-
-
-
Twins comparison suggest lipids metabolism implications
by frodo » Thu Nov 12, 2020 4:04 am » in MS Etiology and Pathogenesis - 0 Replies
- 244 Views
-
Last post by frodo
Thu Nov 12, 2020 4:04 am
-
-
-
More about Tcells. CD8+ Tcells dysregulation
by frodo » Thu Jun 27, 2019 12:48 am » in MS Etiology and Pathogenesis - 0 Replies
- 397 Views
-
Last post by frodo
Thu Jun 27, 2019 12:48 am
-
-
-
Herpesvirus HHV-6B strain linked to MS
by frodo » Tue Dec 10, 2019 3:52 am » in MS Etiology and Pathogenesis - 0 Replies
- 639 Views
-
Last post by frodo
Tue Dec 10, 2019 3:52 am
-
-
- 6 Replies
- 835 Views
-
Last post by NHE
Wed Sep 18, 2019 2:40 pm
-
- 0 Replies
- 2798 Views
-
Last post by NHE
Fri Mar 22, 2019 11:31 pm