Specific image biomarker: Paramagnetic rim lesions

[frodo]

Currently there is no specific single test to diagnose MS. This won't be the first one because of its low sensitivity, but they say that specificity is 100% when PRL (paramagnetic rim lesions) is used together with OCB's, CVS (central vein sign) and DIS (dissemination in space)

CVS detection alone has high specificity (96%) ant together with PRL they reach 99%.

PARAMAGNETIC RIM LESIONS ARE SPECIFIC TO MULTIPLE SCLEROSIS: AN INTERNATIONAL MULTICENTER 3T MRI STUDY

https://onlinelibrary.wiley.com/doi/abs ... /ana.25877

Abstract

In multiple sclerosis (MS), a subset of chronic active white matter lesions are identifiable on MRI by their paramagnetic rims, and increasing evidence supports their association with clinical disease severity.

Here we study their potential role in differential diagnosis, screening an international multicenter clinical research‐based sample of 438 individuals affected by different neurological conditions (MS, other inflammatory, infectious, and non‐inflammatory).

Paramagnetic rim lesion detection, rarely occurring in other neurological conditions (52% of MS vs 7% of non‐MS cases), yielded high specificity (93%) in differentiating MS from non‐MS.

Future prospective multicenter studies should further validate its role as a diagnostic biomarker.