Mass cytometry provides insight into the role of B cells

A forum to discuss research on the origins of MS and its development.
Post Reply
User avatar
frodo
Family Elder
Posts: 1521
Joined: Wed Dec 02, 2009 3:00 pm
Contact:

Mass cytometry provides insight into the role of B cells

Post by frodo » Thu Aug 27, 2020 5:43 am

Mass cytometry provides unprecedented insight into the role of B cells during the pathogenesis of multiple sclerosis

https://www.acnr.co.uk/wp-content/uploa ... 12to14.pdf

Abstract

In recent years, it has become clear that B cells play a prominent role in the pathogenesis of multiple sclerosis (MS). This is most evident when considering the effectiveness of anti-CD20 monoclonal therapeutics including rituximab and ocrelizumab.

In fact many successful therapeutics alter the level of switched memory B cells. It is however unlikely all switched memory B cells are detrimental in the context of MS. The ability to distinguish between various B cell subsets is hence important if we are to more specifically target detrimental from potentially beneficial B cells.

Mass cytometry provides the ability to interrogate a larger number of markers in a single experiment, allowing unprecedented insight into B cell subsets and how they contribute to MS disease progression.

This review highlights the importance of investigating B cells in the context of MS, and how mass cytometry provides the ability to interrogate a large number of subsets for an in-depth characterisation.

Post Reply
  • Similar Topics
    Replies
    Views
    Last post

Return to “MS Etiology and Pathogenesis”