Sorry to take this off-topic, Thekla. Have you looked into the possibility of a B12 deficiency? There are many points in this video from the University of Wisconsin, Madison, that I do not agree with; however, this section on taking medication is confirmed in other sources – @11:40 it is said that cholestyramine binds effectively to bile and effectively takes out B12, rendering patients deficient; the drug decreases Intrinsic Factor receptors in ileal mucosa by blocking ileal cell proliferation.Thekla wrote:jimmylegs, How do you feel about the nightshades? I've heard rumblings about them on and off for years and lately cholinesterase inhibitors. I really hate the idea of eliminating chili peppers, etc from my diet. I prefer a modified wahl's/paleo with loads of veggies and grassfed meats including organ meats---they are cheaper! Incidentally, wild/game meats might be an option for those in Eastern Europe and homemade sauerkraut for probiotics! Incidentally, I had difficulty with the sheer quantity of food on the wahls diet. In 6 months, I gained weight and didn't fit in my clothes.
Vitamin B12: New Understanding and Approach to an Old Problem
University of Wisconsin, Madison; Department of Family Medicine physician, Irene Hamrick, MD, discusses Vitamin B-12 deficiency with some tips on diagnosis and treatment.
Back on the topic of Dr. Terry Wahls' protocol…Compliments of Kronk:The following reduce vitamin B12 absorption or availability: metformin, cholestyramine, and omeprazole.
competes with calcium necessary for ileal receptor transport,
reverses with calcium intake
Caspary 1977;Bauman 2000; Gilligan 2002
Cholestyramine (@11:40 "binds effectively to bile and effectively takes out B12, rendering patients deficient; decreases IF receptors in ileal mucosa by blocking ileal cell proliferation"
Coronato A, Glass GB 1973Proc Soc Exp Biol Med. 142:1344
reduces Intrinsic Factor receptors in ileal mucosa by blocking villous cell proliferation
Webb DI, et al. 1968 NEJM 279:845-850
Stopa EG, et al. 1979 Gastroenterology 76;2:309-14
J Altern Complement Med. 2014 May;20(5):347-55. doi: 10.1089/acm.2013.0188. Epub 2014 Jan 29.
A multimodal intervention for patients with secondary progressive multiple sclerosis: feasibility and effect on fatigue.
Bisht B, Darling WG, Grossmann RE, Shivapour ET, Lutgendorf SK, Snetselaar LG, Hall MJ, Zimmerman MB, Wahls TL
University of Iowa College of Liberal Arts and Sciences, University of Iowa, Iowa City, IA
Multiple sclerosis is an autoimmune disease influenced by environmental factors.
The feasibility of a multimodal intervention and its effect on perceived fatigue in patients with secondary progressive multiple sclerosis were assessed.
This was a single-arm, open-label intervention study in an outpatient setting.
A multimodal intervention including a modified paleolithic diet with supplements, stretching, strengthening exercises with electrical stimulation of trunk and lower limb muscles, meditation, and massage was used.
Adherence to each component of the intervention was calculated using daily logs. Side-effects were assessed from a monthly questionnaire and blood analyses. Fatigue was assessed using the Fatigue Severity Scale (FSS). Data were collected at baseline and months 1, 2, 3, 6, 9, and 12.
Ten (10) of 13 subjects who were enrolled in a 2-week run-in phase were eligible to continue in the 12-month main study. Of those 10 subjects, 8 completed the study and 6 subjects fully adhered to the study intervention for 12 months. Over a 12-month period, average adherence to diet exceeded 90% of days, and to exercise/muscle stimulation exceeded 75% of days. Nutritional supplements intake varied among and within subjects. Group daily average duration of meditation was 13.3 minutes and of massage was 7.2 minutes. No adverse side-effects were reported. Group average FSS scores decreased from 5.7 at baseline to 3.32 (p=0.0008) at 12 months.
In this small, uncontrolled pilot study, there was a significant improvement in fatigue in those who completed the study. Given the small sample size and completer rate, further evaluation of this multimodal therapy is warranted.