Amylase-trypsin inhibitors in wheat may worsen inflammation

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Amylase-trypsin inhibitors in wheat may worsen inflammation

Post by NHE » Wed Dec 07, 2016 10:06 pm

A recently discovered family of proteins in wheat, amylase-trypsin inhibitors, may be responsible for wheat sensitivity problems.

Your Wheat Sensitivity May Have Nothing to Do With Gluten
Scientists are focusing on a new protein found in wheat

When most people think of wheat-related health issues, they think of gluten, a protein found in wheat, barley, and rye that’s harmful for anyone with celiac disease. But gluten may not be the only culprit: A different family of proteins found in wheat and other grains—called amylase-trypsin inhibitors (ATIs)—has also piqued the interest of scientists in recent years. And now, German researchers say that ATIs appear to cause inflammation, and make chronic health conditions worse.

According to the scientists from the Johannes Gutenberg University, for some people, eating ATIs (which make up no more than 4% of wheat proteins) can trigger powerful immune responses in the gut that can affect other parts of the body, including the lymph nodes, kidneys, spleen, and brain.

This reaction can worsen chronic conditions, such as multiple sclerosis, asthma, rheumatoid arthritis, and inflammatory bowel diseases like Crohn’s disease and ulcerative colitis, they say. It also likely contributes to the development of a condition known as non-celiac gluten sensitivity, in which people test negative for celiac disease but still suffer gastrointestinal pain, fatigue, and other unpleasant symptoms after eating bread, pasta, and other wheat products. (Celiac disease is a serious condition in which an autoimmune reaction to gluten damages the intestines, causing diarrhea, weight loss, and nutritional deficiencies.)

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